Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Provide comprehensive primary eye care while fostering a patient-first culture. Collaborate with a supportive team to deliver personalized treatment and education, ensuring high-quality care and oppor...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$90K - $135K *

Transform business development strategies by leading service contract bids for PV and BESS projects. Collaborate with cross-functional teams to enhance processes and drive growth in diverse markets wh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$220K - $250K *

Shape customer success by leading technical sales engagements, driving evaluations, and delivering tailored solutions. Collaborate with teams to ensure seamless deployment and integration, while build...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform the supply chain landscape by leading strategies for operational excellence, inventory management, and supplier partnerships, driving growth and enhancing customer satisfaction while fosteri...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$65K - $98K *

Help us drive efficiency in transportation operations by leading a dynamic team to optimize logistics services, ensuring timely and safe delivery of goods while maintaining high standards of quality a...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Champion healthcare solutions by managing integrations and providing expert support. Drive projects and improve processes as a Senior Interface Analyst in a dynamic and innovative environment, ensurin...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $408K *

Transform healthcare delivery by leading medical management and quality initiatives. Collaborate with clinical teams to enhance patient outcomes and drive cost-effective care while ensuring compliance...

Missouri, USRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Partner with us to design and implement engaging front-end experiences for leading eCommerce brands. Leverage your skills in Figma and Shopify to create custom loyalty solutions, collaborating closely...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $296K *

Advance strategic partnerships by engaging with top tech companies, driving growth through innovative collaborations. Lead negotiations from inception to launch, ensuring impactful results for family...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$78K - $119K *

Lead a dynamic team of analysts to drive strategic insights and operational excellence across Revenue Operations. Collaborate with stakeholders, navigate complex challenges, and enhance analytical cap...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $158K *

Join us in transforming health care by leading a pharmacy team dedicated to patient care, safety, and operational excellence. Your expertise will enhance patient experiences and ensure compliance whil...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Lead the charge in optimizing operations for a virtual clinic, enhancing service delivery and patient experience. Drive strategic initiatives and implement data-driven improvements to support families...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion safe and effective drug therapy by collaborating with healthcare teams to optimize patient outcomes. Serve as a vital drug information resource, ensuring evidence-based medication management...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Drive growth by promoting innovative regenerative medicine solutions. Leverage your expertise in vascular surgery sales and establish strong customer relationships to achieve targets and make a meanin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Reimagine cloud infrastructure as you build and operate scalable systems that empower product teams. Ensure reliability and speed in a dynamic environment, supporting enterprise-scale solutions for Fo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive client satisfaction as a Senior Project Manager, overseeing eDiscovery projects, managing budgets, and consulting on best practices. Lead teams, enhance workflows, and ensure timely delivery whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Elevate your career by leading innovative water and wastewater projects. Collaborate with clients and teams to deliver exceptional design, planning, and operational services in a dynamic environment f...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Provide expert technical support and solutions to enhance customer success with Mastercam products, collaborating with teams to optimize workflows and drive product improvements in the West region...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$160K - $192K *

Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$116K - $174K *

Join a team that's driving operational excellence in transportation management. This role focuses on optimizing freight movement, enhancing service levels, and ensuring compliance while leading a dyna...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$112K - $196K *

Unlock potential by leading BIM initiatives and enhancing digital design workflows. Collaborate across teams to implement cutting-edge technologies, drive best practices, and support project delivery...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$102K - $182K *

Lead the design and delivery of innovative clinical sales training programs for Structural Heart, enhancing sales team effectiveness and product knowledge through strategic curriculum development and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$60K - $132K *

Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion innovative EBOS design solutions for utility-scale solar projects, ensuring compliance, manufacturability, and cost-efficiency while mentoring junior engineers and collaborating cross-functio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$114K - $140K *

Join a team that's transforming digital services by delivering innovative Salesforce solutions. Collaborate with stakeholders to enhance CRM capabilities, ensuring secure and efficient platform delive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.