Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$250K - $500K *
Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...
1 week ago
Manager, Quality Assurance - Western U.S. (West of the Mississippi) & Florida
$123K - $160K *
Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...
1 week ago
Project Manager - Substation (Midwest Region)
$145K - $210K *
Unlock potential by leading electrical substation projects, managing client relationships, and ensuring successful project delivery from concept to completion while driving business growth and maintai...
1 week ago
Regional Business Director - Northeast
$150K - $180K *
Explore an impactful leadership role driving sales strategies and team development in the PAH marketplace. Collaborate with cross-functional teams to enhance performance and foster relationships with...
1 week ago
Director, Value Consulting & Digital Transformation
$113K - $160K *
Champion the quantification of business impact from technology and transformation investments. Lead financial modeling and value realization efforts, translating insights into actionable recommendatio...
1 week ago
Regional Dedicated Transportation Manager
$80K - $95K *
Reimagine operational excellence by leading a regional team to optimize performance, enhance customer satisfaction, and ensure compliance. Drive financial success while fostering a safe and efficient...
1 week ago
Managed Care Contracting and Performance Advisor
$113K - $188K *
Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...
1 week ago
Home Health RN 7 On 7 Off On Call
$80K - $95K *
Join our dedicated team to provide compassionate nursing care through skilled visits, patient education, and collaboration with healthcare professionals, ensuring comfort and support for patients in t...
1 week ago
Senior Financial Analyst, FP&A
$90K - $120K *
Drive financial excellence by collaborating across teams to enhance planning and reporting processes. This role blends detailed analysis with strategic insight, offering visibility into key leadership...
Reposted 1 week ago
Sr. Analyst, External Reporting
$80K - $95K *
Unlock potential by serving as a global expert in financial reporting, overseeing SEC filings and internal controls to enhance the integrity of consolidated financial statements, while collaborating w...
Reposted 1 week ago
Associate Underwriter, Northeast
$70K - $100K *
Join a dynamic team to drive profitable business through strategic underwriting and broker partnerships. Leverage your expertise to enhance client relationships and contribute to innovative solutions...
1 week ago
21GRAMS- Associate Creative Director, Copy
$160K - $180K *
Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...
1 week ago
Nurse Practitioner or Physician Assistant (Hybrid) - Breast Oncology
$97K - $174K *
Join a team that's dedicated to providing exceptional care in Breast Medical Oncology. This hybrid role combines patient care and administrative duties, allowing you to support patients through their...
1 week ago
Senior Marketing Manager, Field & Partner
$100K - $120K *
Shape the future of partner and field marketing by driving demand and revenue through strategic programs. Collaborate with partners and execute hands-on initiatives to enhance relationships and achiev...
1 week ago
Staff Site Reliability Engineer
$109K - $156K *
Champion reliability by leading SRE projects from inception to production. Collaborate with teams to enhance infrastructure across hybrid environments, driving architectural excellence and operational...
1 week ago
$95K - $115K *
Champion user experience by enhancing our insurance platform's web interface. Collaborate with teams to simplify design, implement UX initiatives, and develop solutions that empower agents and interna...
1 week ago
Lead Solution Marketing Manager, Cybersecurity Segments and Industries
$93K - $124K *
Lead the development of compelling cybersecurity narratives and content that connect technology solutions to customer needs. Collaborate across teams to create impactful sales enablement materials and...
1 week ago
Senior Staff Machine Learning Engineer - US
$150K - $180K *
Champion innovative AI platform architecture and drive enterprise-level integration of machine learning, ensuring security, accuracy, and reliability across systems while mentoring teams to elevate te...
Reposted 1 week ago
Procurement Operations Analyst
$115K - $150K *
Elevate procurement operations by managing vendor coordination, documentation, and process consistency. This role focuses on execution and queue management, ensuring timely and organized procurement s...
1 week ago
Software Engineering Program Manager
$120K - $145K *
Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...
1 week ago
$108K - $140K *
Transform talent acquisition by leading a dynamic recruiting team, driving data-informed strategies, and enhancing candidate experiences to meet organizational growth and workforce needs...
1 week ago
Director, Enterprise Enablement
$150K - $180K *
Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...
Reposted 1 week ago
Specialist Seller, Enterprise Core (Tracking Label)
$222K - $278K *
Empower businesses by eliminating supply chain blind spots. Drive adoption of our innovative Tracking Label product, collaborating with Enterprise teams to enhance shipment visibility and security acr...
1 week ago
$160K - $200K *
Drive the evolution of Sales Operations by designing and optimizing processes, governance, and technology to enhance execution and productivity across the organization, ensuring alignment with strateg...
1 week ago
Account-Based Marketing Manager
$100K - $155K *
Empower targeted marketing initiatives that drive engagement and revenue growth. Collaborate with Sales and Product teams to create personalized strategies, leveraging insights and AI tools to enhance...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.