Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Shape the future of materials management by leading a cohesive team. Ensure material availability, optimize inventory, and drive supplier performance to meet production needs. Engage in continuous imp...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Engineer and develop functional tests for embedded firmware in advanced metering infrastructure. Collaborate with a team to ensure quality and compliance in electronic systems, contributing to innovat...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Reimagine automated systems by leading a talented team of technicians to enhance equipment reliability, safety, and productivity through effective maintenance, troubleshooting, and continuous improvem...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $223K *

Unlock potential by leading human-centered design efforts in clinical settings, translating user insights into AI-enabled solutions that enhance patient care and clinician efficiency within a collabor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $160K *

Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$160K - $229K *

Transform client experiences by leading SAP CX solutions, ensuring seamless integration and delivery from discovery to go-live while collaborating with cross-functional teams to drive business success...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$109K - $144K *

Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $173K *

Unlock potential by leading the commissioning of hyperscale data centers. Manage project lifecycles, coordinate teams, and ensure compliance with client requirements while fostering strong stakeholder...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$150K - $180K *

Manage and coordinate patient scheduling and inventory control while enhancing operational efficiency. Collaborate across departments to develop business strategies, oversee budgets, and maintain comp...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$123K - $135K *

Engage with existing customer accounts to drive renewal retention and expansion revenue. Collaborate with cross-functional teams to identify growth opportunities and ensure customer satisfaction while...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $210K *

Champion innovative content strategies to transform editorial operations, enhance audience engagement, and establish a trusted resource for leaders in government and education. Drive organizational ch...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$90K - $95K *

Advance your career by driving new business growth through proactive outreach, building strong relationships, and consistently exceeding sales targets in a dynamic, remote environment focused on B2B s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Manage client engagements end-to-end while mentoring associates and driving team success. Leverage technical expertise to resolve complex tax issues and enhance client service through collaboration an...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$250K - $300K *

Shape the future of AI-powered implementations by leading a dynamic team, redefining best practices, and building a robust partner ecosystem to enhance client success and drive growth in a fast-paced...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$80K - $95K *

Lead the charge in executing underground utility projects, ensuring safety and quality while overseeing field operations and crews. Drive efficiency and mentor teams through complex installations and...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$131K - $243K *

Advance your career by driving enterprise sales and building strong client relationships. Leverage your expertise in SaaS solutions to identify opportunities, negotiate contracts, and deliver tailored...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$104K - $143K *

Lead the charge in developing and delivering innovative technology solutions for managing Medicare/Medicaid plans. Collaborate with cross-functional teams to drive product vision, strategy, and execut...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $176K *

Empower a dynamic team by leading supply chain strategies, enhancing material availability, and optimizing inventory management across multiple sites to meet business goals and customer commitments in...

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$110K - $130K *

Join a team that's redefining art leadership in live-service games. You'll empower Art Leads, enhance team operations, and ensure high-quality art delivery across our portfolio, fostering creativity a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Shape the future of product design by leading innovative initiatives, driving user insights, and enhancing user experiences across multiple platforms. Collaborate closely with product and engineering...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $140K *

Lead the strategy and execution of web growth initiatives, optimizing SEO, GEO, and AEO to enhance user experience and drive conversions. Collaborate with cross-functional teams to implement data-driv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Unlock potential by leading financial operations and strategic analysis. Drive accuracy in reporting, enhance processes, and collaborate across teams to support informed decision-making while managing...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$68K - $126K *

Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $115K *

Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.