Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$95K - $115K *
Shape the future of materials management by leading a cohesive team. Ensure material availability, optimize inventory, and drive supplier performance to meet production needs. Engage in continuous imp...
Reposted 1 week ago
$80K - $95K *
Engineer and develop functional tests for embedded firmware in advanced metering infrastructure. Collaborate with a team to ensure quality and compliance in electronic systems, contributing to innovat...
Reposted 1 week ago
Automation Manager - Centralia, MO
$95K - $115K *
Reimagine automated systems by leading a talented team of technicians to enhance equipment reliability, safety, and productivity through effective maintenance, troubleshooting, and continuous improvem...
Reposted 1 week ago
Senior Forward Deployed UX Designer (Asheville, NC or Nashville, TN)
$140K - $223K *
Unlock potential by leading human-centered design efforts in clinical settings, translating user insights into AI-enabled solutions that enhance patient care and clinician efficiency within a collabor...
1 week ago
$110K - $150K *
Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...
1 week ago
$100K - $160K *
Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...
1 week ago
$160K - $229K *
Transform client experiences by leading SAP CX solutions, ensuring seamless integration and delivery from discovery to go-live while collaborating with cross-functional teams to drive business success...
1 week ago
Operations Support & Strategy Manager
$109K - $144K *
Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...
1 week ago
$133K - $173K *
Unlock potential by leading the commissioning of hyperscale data centers. Manage project lifecycles, coordinate teams, and ensure compliance with client requirements while fostering strong stakeholder...
1 week ago
Executive Director Surgical Service
$150K - $180K *
Manage and coordinate patient scheduling and inventory control while enhancing operational efficiency. Collaborate across departments to develop business strategies, oversee budgets, and maintain comp...
Reposted 1 week ago
Account Manager, Client Development & Renewals (Chicago / Midwest)
$123K - $135K *
Engage with existing customer accounts to drive renewal retention and expansion revenue. Collaborate with cross-functional teams to identify growth opportunities and ensure customer satisfaction while...
1 week ago
Chief Editorial and Insights Officer
$200K - $210K *
Champion innovative content strategies to transform editorial operations, enhance audience engagement, and establish a trusted resource for leaders in government and education. Drive organizational ch...
1 week ago
Business Development Executive
$90K - $95K *
Advance your career by driving new business growth through proactive outreach, building strong relationships, and consistently exceeding sales targets in a dynamic, remote environment focused on B2B s...
1 week ago
$80K - $95K *
Manage client engagements end-to-end while mentoring associates and driving team success. Leverage technical expertise to resolve complex tax issues and enhance client service through collaboration an...
1 week ago
VP, Law Firm Professional Services
$250K - $300K *
Shape the future of AI-powered implementations by leading a dynamic team, redefining best practices, and building a robust partner ecosystem to enhance client success and drive growth in a fast-paced...
1 week ago
Underground Pipe Superintendent - Eastern District
$80K - $95K *
Lead the charge in executing underground utility projects, ensuring safety and quality while overseeing field operations and crews. Drive efficiency and mentor teams through complex installations and...
1 week ago
$131K - $243K *
Advance your career by driving enterprise sales and building strong client relationships. Leverage your expertise in SaaS solutions to identify opportunities, negotiate contracts, and deliver tailored...
1 week ago
Senior Technical Product Manager - Insurance Products & Benefits
$104K - $143K *
Lead the charge in developing and delivering innovative technology solutions for managing Medicare/Medicaid plans. Collaborate with cross-functional teams to drive product vision, strategy, and execut...
Reposted 1 week ago
Director, Supply Chain Planning & Materials
$130K - $176K *
Empower a dynamic team by leading supply chain strategies, enhancing material availability, and optimizing inventory management across multiple sites to meet business goals and customer commitments in...
1 week ago
$110K - $130K *
Join a team that's redefining art leadership in live-service games. You'll empower Art Leads, enhance team operations, and ensure high-quality art delivery across our portfolio, fostering creativity a...
1 week ago
$120K - $145K *
Shape the future of product design by leading innovative initiatives, driving user insights, and enhancing user experiences across multiple platforms. Collaborate closely with product and engineering...
1 week ago
$115K - $140K *
Lead the strategy and execution of web growth initiatives, optimizing SEO, GEO, and AEO to enhance user experience and drive conversions. Collaborate with cross-functional teams to implement data-driv...
1 week ago
Finance and Accounting Manager
$80K - $95K *
Unlock potential by leading financial operations and strategic analysis. Drive accuracy in reporting, enhance processes, and collaborate across teams to support informed decision-making while managing...
1 week ago
$68K - $126K *
Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...
1 week ago
$90K - $115K *
Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.