Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Shape the future of automotive sales by leading a dynamic team, developing strategic initiatives, and engaging directly with clients to enhance their repair processes while achieving ambitious sales t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$97K - $115K *

Unlock insights into financial crime by investigating complex AML cases, driving compliance initiatives, and collaborating with stakeholders to enhance detection models and operational efficiency in a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $200K *

Bring your expertise to lead sales strategies and customer development across NCC and VIS product lines, driving profitable growth and enhancing commercial processes while fostering collaboration with...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead strategic planning and execution of investigative programs, ensuring alignment with organizational goals. Oversee multiple teams, manage resources, and provide expert guidance on law enforcement...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$79K - $109K *

Transform financial operations by owning monthly close processes, ensuring accurate COGS and accruals. Collaborate with leadership to drive data-driven decisions in a dynamic, growth-stage tech enviro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$124K - $171K *

Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $120K *

Join a team that's committed to operational excellence, overseeing technical operations and maintenance for a federal courthouse. Lead a skilled team to ensure safety, reliability, and compliance whil...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Lead strategic planning and execution of criminal investigations, ensuring compliance with IRS objectives. Oversee subordinate units, manage resources, and advise on legal matters to enhance operation...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$115K - $151K *

Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$138K - $165K *

Drive GitLab's Secret Detection and Vulnerability Research efforts to shape security product outcomes. Own the detection lifecycle, ensure content quality, and leverage AI to enhance operational effic...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Drive innovation in power systems architecture by collaborating with hyperscalers and partners to develop cutting-edge connector and cable solutions. Lead technical programs, influence strategic objec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$210K - $250K *

Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $150K *

Lead the charge in enhancing sales performance through targeted enablement initiatives. You'll work closely with diverse sales teams to coach, train, and build effective tools, ensuring impactful and...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$102K - $190K *

Lead the charge in managing firewall infrastructure engineering, ensuring operational excellence, scalability, and security. Drive team performance, oversee lifecycle management, and enhance capabilit...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$82K - $114K *

Join a team that's driving innovation in digital and automation projects, ensuring compliance and standardization across capital initiatives in manufacturing environments. Collaborate with stakeholder...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$90K - $105K *

Elevate your career by leading administrative functions and strategic initiatives. Collaborate with senior management to enhance operations, oversee diverse teams, and drive impactful policies within...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$117K - $150K *

Champion your actuarial expertise to drive financial reporting and reserve setting for annuities. Collaborate on high-impact projects, adapt to evolving needs, and enhance reporting models in a dynami...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Advance business growth by building strategic relationships and identifying client needs. Drive sales initiatives and ensure seamless implementation of client programs while meeting profit margins and...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Lead the charge in project management excellence, overseeing a dynamic team to ensure financial performance and client satisfaction across a diverse portfolio of construction projects. Drive continuou...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Optimize backend systems for a financial platform, integrating AI features and ensuring reliability across multiple regions. Collaborate with global teams to enhance product capabilities and maintain...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.