Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $199K *

Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in web growth design, optimizing top-of-funnel experiences to enhance customer engagement and conversion. Collaborate with cross-functional teams to create compelling, high-quality web...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Unlock potential by leading the full sales cycle, building executive relationships, and driving business transformation across industries. Collaborate with teams to innovate sales processes and ensure...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$315K - $370K *

Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Unlock potential by leading compliance initiatives and advising leadership on regulatory strategies. This role ensures adherence to laws, mentors staff, and collaborates with stakeholders to mitigate...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $195K *

Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead the design and maintenance of robust network solutions, ensuring optimal performance and security across Local and Wide Area Networks. Collaborate with teams to implement innovative technologies...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Shape the future of network solutions by maintaining and enhancing LAN/WAN operations. Collaborate on innovative architectures to boost efficiency, security, and scalability while ensuring compliance...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the design and maintenance of Local and Wide Area Networks, enhancing efficiency and security. Collaborate on innovative solutions and ensure network reliability while adhering to industry standa...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$185K - $220K *

Lead the charge in financial reporting and cost control for manufacturing operations, ensuring accuracy and transparency. Collaborate with cross-functional teams to drive strategic growth and maintain...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $95K *

Unlock potential by managing Genesys Cloud configurations and ensuring system integrity. Collaborate with teams to implement changes, troubleshoot issues, and maintain documentation for optimal contac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$240K - $290K *

Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$154K - $242K *

Champion operational excellence by leading global tax provisions and compliance. Collaborate with cross-functional teams to enhance processes, mentor talent, and drive strategic tax initiatives while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share within the dental implant community. Leverage a hunter mentality to convert competitive accounts and position value-ori...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$130K - $150K *

Optimize IT operations by managing systems, enhancing security, and leading projects. Ensure seamless network infrastructure and provide technical support while coordinating with vendors and maintaini...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Shape the future of data and AI solutions by driving product success, collaborating with cross-functional teams to align business goals with innovative platforms and ensuring continuous improvement th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$124K - $153K *

Transform financial management practices by leading budgeting, forecasting, and resource allocation efforts. Collaborate with teams to enhance decision-making and optimize financial systems, ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $275K *

Lead the charge in building and scaling a dynamic partner program, driving revenue through strategic alliances and co-selling. Collaborate cross-functionally to establish processes and integrations, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Champion product excellence by owning the vision, backlog, and delivery outcomes. Collaborate with stakeholders and technical teams to ensure solutions align with business goals and regulatory standar...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Lead the charge in enhancing client relationships and driving value realization for managed services. Oversee client success strategies, retention, and growth while collaborating cross-functionally to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Engage with business leaders to drive digital transformation initiatives, enhance operational efficiency, and deliver innovative technology solutions. Collaborate across teams to translate needs into...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Elevate sustainability initiatives by leading client engagements in impact inventory, strategy development, and target tracking. Utilize analytical tools to transform sustainability challenges into ac...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.