Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Advance your career by developing cutting-edge marine chiller systems. Lead engineering projects, innovate HVAC&R solutions, and collaborate on product design to meet commercial and defense needs whil...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$93K - $125K *

Join us as a Senior Test Engineer to lead the planning and execution of complex product testing, utilizing your expertise to assess performance criteria across various systems while collaborating with...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$79K - $103K *

Transform cost estimation processes by collaborating with multifaceted teams to deliver precise material pricing for DoD proposals, ensuring compliance and competitiveness while supporting strategic d...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$242K - $290K *

Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Manage progress at construction sites, ensuring adherence to safety, schedule, and quality standards while overseeing craft and subcontractor performance for successful project execution...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $160K *

Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $106K *

Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K - $100K *

Unlock potential by spearheading talent acquisition strategies and cultivating relationships with leadership. Drive recruitment across various functions while mentoring teams to build a pipeline of to...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Lead the charge in shaping architectural design and integrity of core systems. Collaborate with senior leaders to set technical direction, evaluate new technologies, and resolve complex issues, paving...

1 week ago

  •   8 - 10 years exp.  •   Transportation

$80K - $95K *

Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Optimize predictive modeling initiatives by designing and implementing advanced actuarial pricing models. Collaborate with cross-functional teams to ensure compliance and drive strategic pricing solut...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Drive impactful pricing strategies by developing predictive models that enhance segmentation and lifetime value. Collaborate with cross-functional teams to ensure compliance and deliver high-quality a...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $125K *

Lead recruitment and talent development initiatives to attract top legal professionals, enhance performance evaluations, and implement HR policies, fostering a culture of excellence and collaboration...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $140K *

Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $105K *

Champion safety initiatives across multiple locations, enhancing EHS programs and training while collaborating with operations to ensure compliance and continuous improvement in a dynamic industrial e...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$200K - $220K *

Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$180K - $220K *

Optimize revenue and profitability as you lead commercial finance, drive pricing strategies, and negotiate pivotal agreements with stakeholders, playing a vital role in shaping financial success acros...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$239K - $298K *

Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive your career with impactful first-line support for flight simulator software, troubleshooting hardware, and collaborating with cross-functional teams to enhance customer experience and resolve te...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$225K - $250K *

Lead the charge in pioneering technology strategies that enhance operational excellence and drive innovation across multiple business units. Partner with leaders to implement advanced solutions in AI...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Transform your career by leading strategic marketing initiatives that enhance brand visibility and drive revenue growth. Collaborate with cross-functional teams to create compelling content and optimi...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead strategic planning and execution of investigative programs, ensuring alignment with organizational goals. Oversee multiple units, manage resources, and provide guidance to enhance operational eff...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.