Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$88K - $105K *

Engage in comprehensive finance integration for acquired companies, ensuring accurate data mapping, system conversion, and post-close stabilization. Collaborate with cross-functional teams to streamli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Elevate cloud security and reliability by leading DevOps practices across teams. You'll optimize AWS and GCP environments, enhance CI/CD pipelines, and ensure cost-effective engineering tools, driving...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$165K - $215K *

Architect innovative solutions to complex technical challenges, driving platform direction and enabling deep specialists. You'll tackle high-leverage problems that define our future capabilities and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$149K - $205K *

Contribute to engineering compliance by leading audits and assessments across North American factories. Drive standardization, mitigate risks, and enhance regulatory adherence while collaborating with...

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$95K - $137K *

Contribute to marketing strategies and brand goals by leading projects across consumer communications and product innovation, while inspiring cross-functional teams to execute effectively and efficien...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$75K - $99K *

Empower production efficiency by supervising teams and driving continuous improvement. Oversee scheduling, quality compliance, and safety for optimal output and equipment maintenance while fostering e...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$143K - $190K *

Lead the charge in delivering scalable digital solutions by establishing standards and practices across teams and vendors. Drive performance management and integrated planning to ensure successful pro...

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$80K - $95K *

Redefine the HVAC&R industry by developing innovative products for commercial and defense markets. Collaborate on testing and analysis, support design tasks, and provide thermodynamic insights to driv...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$85K - $144K *

Engineer comprehensive pricing strategies that maximize revenue and profitability while leveraging data analytics and automation tools. Collaborate with cross-functional teams to establish pricing fra...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Pioneer sustainable growth by leading strategic initiatives, strengthening client relationships, and enhancing operational excellence in commercial construction. Drive performance and cultivate top ta...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $120K *

Engage and drive regional growth for comprehensive due diligence services in the Midwest. Build strategic relationships with key stakeholders in commercial real estate, delivering actionable insights...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Unlock potential by leading complex commercial real estate due diligence projects. Collaborate with multidisciplinary teams to provide technical guidance and client leadership, ensuring high-quality d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K *

Take ownership of community outreach initiatives, leading diverse programs to enhance housing and recovery services. Cultivate partnerships, inspire teams, and drive innovative solutions to improve li...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Take ownership of complex construction projects in the justice sector, overseeing management, safety, and quality assurance while leading diverse teams to successful completion and lasting impact...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Manage complex low voltage construction projects, ensuring quality, safety, and budget adherence. Collaborate with trade partners and oversee execution while developing efficient workflows to deliver...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$162K - $203K *

Join a team that's transforming digital tinnitus care in the U.S. by leading commercial execution across healthcare sectors. Drive adoption and optimize partnerships to enhance patient engagement and...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Drive growth by leading sales and technical initiatives in heating and combustion solutions across the Southeast Region, fostering relationships with key clients and internal teams to achieve strategi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$186K - $218K *

Architect robust security solutions to safeguard corporate infrastructure and user devices. Collaborate with IT and engineering teams to identify risks and implement effective security measures, ensur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $185K *

Accelerate your career by executing regional payor strategies to secure coverage and reimbursement for innovative Surgical Glaucoma products. Collaborate with cross-functional teams and build relation...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$101K - $158K *

Lead enterprise-wide cybersecurity initiatives, aligning operations and compliance with strategic goals. Drive actionable security plans, manage risks, and enhance capabilities while fostering a high...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Elevate patient care by joining a dynamic optometry practice, where you'll enjoy professional autonomy and flexible scheduling while utilizing advanced technology to provide exceptional eye care servi...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$163K - $203K *

Elevate security standards by leading classified design and accreditation for defense facilities. Collaborate with cross-functional teams to ensure compliance and streamline processes for rapid deploy...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$204K - $216K *

Lead the charge in enhancing compliance operations and financial oversight for multi-billion-dollar loan and grant programs, ensuring sound accounting practices and providing expert guidance to senior...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$90K - $95K *

Join a team that's driving brand visibility and growth in the on-premise channel. As an On-Premise Specialist, you'll manage key accounts, optimize sales strategies, and collaborate with distributors...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$110K - $130K *

Reimagine operational excellence by integrating data intelligence and insights across multiple business functions. This role enhances strategic decision-making, optimizes workflows, and supports marke...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.