Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Champion client success by leading complex commercial real estate projects, managing multi-site portfolios, and providing senior technical expertise to multidisciplinary teams, ensuring effective deli...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$80K - $95K *

Lead the charge in managing complex construction projects for justice facilities, ensuring timely delivery within budget and fostering a culture of safety and quality. Partner with teams to drive coll...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $200K *

Drive strategic capital allocation and investment management, partnering with top executives to optimize enterprise value across diverse portfolios, while ensuring alignment with business goals and ri...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Unlock your potential as a Senior Project Engineer, managing healthcare construction projects that enhance patient care. Collaborate with diverse teams, ensure quality and safety, and drive project su...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $95K *

Drive excellence in healthcare construction projects by leading teams, managing schedules, and ensuring safety and quality standards. Collaborate with diverse stakeholders to deliver impactful results...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $150K *

Pioneer the national self-perform strategy, collaborating with regional leaders to enhance operations, training, and resource allocation while driving financial performance and project success across...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Advance estimating expertise by leading complex bids and projects, ensuring accuracy and fostering collaboration with stakeholders. Drive profitability and mitigate risks through detailed cost analysi...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Join a dynamic team to prepare complex cost estimates for construction projects, enhancing your skills in estimating processes and collaborating with stakeholders to ensure successful project executio...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $111K *

Partner with us to transform patient care in advanced cochlear implant solutions. Build trusted relationships, execute strategic plans, and improve outcomes by leveraging clinical expertise and consul...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $214K *

Innovate customer experience and automation solutions to streamline real estate closings. Drive strategy, prioritize product roadmaps, and collaborate across teams to enhance operational efficiency an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $215K *

Empower innovation in ophthalmic device development by leading global clinical strategies for surgical programs, from feasibility to regulatory submissions. Collaborate cross-functionally to drive pro...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $200K *

Champion strategic growth and account management with top-tier National Accounts. Lead a team towards innovative solutions, driving revenue and market impact while collaborating across departments for...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $90K *

Lead the charge in cultivating partnerships with Travel Advisors across the Northeast, driving business growth through relationship-building and strategic outreach in the European travel market...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$94K - $266K *

Empower customer success by designing and implementing AWS Connect solutions, conducting technology assessments, and leading project communications to enhance contact center operations and agent produ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $145K *

Lead the charge in innovative healthcare advertising by directing art and design for HCP campaigns. Collaborate with creative teams to transform scientific information into impactful visuals, ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$105K - $182K *

Unlock your potential by driving sales and customer satisfaction in the Great Lakes market. Build strong relationships with retailers while achieving measurable targets and leading initiatives to enha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$84K - $126K *

Join a team that's transforming financial reporting through automation and AI. Leverage your expertise in U.S. Statutory reporting to deliver insights, enhance processes, and drive continuous improvem...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$124K - $171K *

Champion the future of enterprise sales by driving top-down solutions into global enterprises. Leverage AI and LLM technologies to enhance client insights and foster relationships across all organizat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$150K - $165K *

Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$77K - $135K *

Grow your career with us by developing high-quality software solutions as part of a dynamic team. Collaborate on complex projects, enhance your skills, and contribute to innovative software developmen...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Elevate your career by driving OEM sales in the Aerospace & Defense sectors. Lead strategic initiatives, cultivate new business, and enhance market presence across the Pacific Northwest, partnering wi...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$225K - $250K *

Drive growth and strategic direction in Education Communications by leading product portfolios, enhancing customer engagement, and ensuring financial performance aligns with market needs and opportuni...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Drive your career with innovative AI-driven automation solutions that enhance IT operations and user experience. Collaborate across teams to minimize manual tasks, improve efficiency, and implement in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $200K *

Join a team that's driving sales excellence by developing strategic plans, fostering customer relationships, and leading a dynamic sales team to achieve ambitious revenue targets across diverse market...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.