Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Unlock potential by leading project coordination and trade management for advanced technology initiatives, ensuring quality and efficiency across diverse construction environments while supporting ope...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$143K - $176K *

Champion product marketing initiatives across diverse tools, guiding go-to-market strategies and collaborating with cross-functional teams to enhance user engagement and adoption, while driving measur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $110K *

Build strong executive relationships and drive growth in strategic accounts while guiding clients with AI solutions and cloud technology in a fast-paced environment. Leverage your expertise to unlock...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$88K - $105K *

Join our team to lead IT projects that enhance technology and optimize processes. Collaborate across functions to drive improvements, ensuring alignment with business goals while fostering a culture o...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $140K *

Transform customer engagement by configuring and optimizing Salesforce and Agentforce solutions, driving adoption through hands-on implementation and collaboration with clients in a dynamic, iterative...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Shape customer success by building strong partnerships, managing accounts, and translating data into actionable insights. Drive advocacy and operational efficiency while collaborating cross-functional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$268K - $282K *

Shape the future of media products by driving strategy and innovation. Collaborate with cross-functional teams to enhance measurement and optimization capabilities, ensuring impactful solutions for cl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate sourcing strategies by leading procurement for construction products. Drive vendor relationships, negotiate contracts, and analyze market trends to optimize costs and enhance product quality w...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$130K - $155K *

Join us to lead security and compliance initiatives within a dynamic platform team. You'll leverage your expertise to enhance production infrastructure, ensuring robust protection and reliability for...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$150K - $180K *

Empower business growth by building strategic relationships and originating multifamily loans. Utilize your expertise to manage the loan process, advise clients, and enhance community presence in the...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $155K *

Lead cross-functional teams to drive enterprise modernization through AI solutions. Oversee complex implementations, ensuring alignment across technical and business stakeholders while delivering meas...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $220K *

Elevate mental health care by diagnosing and treating patients in a forensic setting. Collaborate with a multidisciplinary team to develop effective treatment plans and restore competency for individu...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in designing a cutting-edge platform for modern data centers, integrating AI and cloud technologies. Collaborate with cross-functional teams to build a robust, scalable architecture th...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $290K *

Contribute to the advancement of cancer therapies by managing analytical development and quality control operations, ensuring compliance with regulatory standards, and collaborating across teams to en...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Deliver hands-on expertise in balancing Steam and Gas Turbines, ensuring safety and quality while collaborating with teams to execute production plans and troubleshoot complex systems effectively...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Champion innovation by leading the strategy and lifecycle of complex AI products. Collaborate across teams to drive adoption and measurable outcomes, ensuring scalable solutions create customer and bu...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$99K - $166K *

Join a dynamic team to manage supplier agreements, ensuring compliance and efficiency in contract administration. Drive governance processes, facilitate stakeholder collaboration, and enhance contract...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$210K - $250K *

Accelerate your career by providing expert Hematology/Oncology care in a collaborative environment. Engage with multidisciplinary teams, manage patient consultations, and contribute to innovative trea...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$93K - $123K *

Engage with enterprise customers to drive complex sales opportunities, leveraging technical expertise and industry knowledge to deliver tailored solutions and compelling presentations that demonstrate...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Shape the future of corporate law by providing strategic legal counsel on M&A, governance, and compliance for a dynamic multinational company. Collaborate with diverse teams to navigate complex transa...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$105K *

Lead the charge in driving new business sales across K-12 districts, building impactful partnerships and advocating for early literacy solutions. Collaborate with internal teams to maximize outreach a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$134K - $241K *

Elevate your career by leading cybersecurity initiatives across California and the West Coast. Drive customer engagement, enhance security compliance, and support critical infrastructure sectors while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$145K - $185K *

Transform account-based marketing strategies into impactful campaigns that drive pipeline growth and revenue. Lead integrated initiatives across multiple channels, ensuring alignment with sales and ma...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $126K *

Lead the charge in optimizing maintenance operations for power plant equipment, ensuring safety, reliability, and efficiency. Drive team performance through coaching and strategic planning to enhance...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$168K - $228K *

Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.