Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $135K *

Lead the transformation of surgical operations, overseeing staff and driving process enhancements to improve efficiency, cost-effectiveness, and revenue in a growing healthcare facility...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $100K *

Optimize data-driven strategies to enhance customer engagement and retention. Collaborate with operations to implement scalable solutions in a dynamic startup environment, making a significant impact...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$200K - $220K *

Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the development and enhancement of digital systems for production operations, focusing on SCADA, HMI, and MES. Collaborate with cross-functional teams to improve efficiency, reliability, and safe...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Help us drive client success by managing campaigns and relationships. You'll oversee a portfolio, lead strategy discussions, optimize Meta campaigns, and ensure client satisfaction through proactive c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Join a dynamic team to implement Real-Time Scheduling solutions, optimizing complex manufacturing processes in the Life Sciences sector. Collaborate with clients to enhance operations through innovati...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$275K - $350K *

Lead the charge in building a subscription research business, driving sales and market strategy across energy, trading, and institutional sectors. Collaborate with analysts to tailor offerings and est...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$213K - $335K *

Optimize legal operations by leveraging technology and AI to enhance efficiency, drive strategic projects, and foster collaboration within a fast-paced healthcare tech environment. Lead a team to impl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$147K - $221K *

Drive efficient dispute resolution as a key legal partner, managing complex litigation and advising cross-functional teams. Collaborate closely with stakeholders to mitigate risks and enhance litigati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Optimize patient-facing and internal tools by delivering seamless integrations and AI-driven features. Take ownership of end-to-end development in a fast-paced telehealth environment focused on men's...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Advance veterinary care by providing compassionate feline medicine with autonomy. Collaborate in a supportive team environment while enjoying flexible scheduling and competitive compensation packages...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining DME resupply operations by leading a global, remote call center. Drive revenue growth, optimize performance, and ensure compliance while managing a diverse workforce to e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Unlock potential by serving as a key legal advisor in a dynamic financial services environment. Navigate complex legal issues, manage internal legal teams, and support business operations while ensuri...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $170K *

Lead the charge in integrating AI capabilities across enterprise platforms, enhancing digital services for Veterans. Collaborate with teams to implement innovative solutions while ensuring security an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in managing supply chain and logistics operations, ensuring accurate inventory control and timely shipments. Collaborate with internal and external partners to optimize processes and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate clinical research by monitoring trials, ensuring compliance with protocols and regulations. Collaborate with investigators to achieve study goals in dermatology and rheumatology, while working...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Invent innovative electronic systems for automotive applications, leveraging engineering principles to design, test, and document engine management components while collaborating with cross-functional...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$115K - $159K *

Elevate our global governance, risk, and compliance programme by leading risk assessments, policy governance, and audit support. Collaborate with cross-functional teams to ensure compliance with ISO 2...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$32K - $137K *

Unlock your potential by guiding clients through financial challenges. Manage inbound calls with a consultative approach, build trust, and exceed performance goals in a supportive, remote environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by driving accurate revenue reporting and enhancing processes. As a Senior Revenue Accountant, you'll collaborate across teams to ensure compliance with ASC 606 while supporting audit...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$77K - $105K *

Transform patient care by coordinating health decisions and discharge plans. Collaborate across multiple locations to enhance treatment outcomes and ensure cost-effective care for individuals facing c...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Unlock potential by driving new logo acquisition in a greenfield territory. Manage the entire sales cycle, build lasting relationships, and shape the future of revenue intelligence as a founding membe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$83K - $119K *

Unlock potential by leading field operations, developing teams, and driving performance across diverse markets. Collaborate with managers and technicians to enhance customer experience and achieve ope...

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $159K *

Drive the transformation of AI agent capabilities into scalable, revenue-generating products. Collaborate across teams to define strategies, evaluate opportunities, and lead product commercialization...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $143K *

Optimize your career by developing and executing clinical marketing strategies that enhance customer engagement and drive adoption of innovative patient monitoring solutions. Collaborate with cross-fu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.