Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$120K - $145K *

Transform client experiences by leading the design and implementation of Oracle HCM Cloud solutions. Collaborate with teams to ensure scalable, reliable, and high-performance technical architectures t...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Drive successful Oracle Cloud HCM implementations by leading Core HR solutions, collaborating with stakeholders, and ensuring best practices for HR operations. Provide functional leadership and mentor...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Staffing

$95K - $150K *

Join a team that's dedicated to empowering small businesses with tailored security solutions. Collaborate with clients to understand their needs and deliver innovative products, while building lasting...

Today

  •   Less than 5 years exp.  •   Business Services

$180K - $215K *

Lead a dynamic team to innovate and enhance healthcare technology solutions. Drive cross-functional collaboration, mentor engineers, and ensure high-quality software delivery while aligning with strat...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a team that's transforming the future of HR by providing expert Oracle Cloud HCM consulting. Lead implementations, mentor clients, and drive innovative solutions across diverse industries while e...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$160K - $180K *

Reimagine customer success by driving onboarding, adoption, and renewals for a diverse portfolio. Collaborate with cross-functional teams to ensure every user thrives, turning initial deployments into...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$211K - $272K *

Transform your career by leading enterprise applications strategy and delivery. Collaborate with cross-functional teams to enhance processes, drive AI adoption, and ensure robust application architect...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$95K - $150K *

Drive your career forward by providing tailored security solutions to small businesses. Collaborate with owners to understand their needs, customize systems, and cultivate lasting relationships while...

Today

  •   Less than 5 years exp.  •   Business Services

$140K - $460K *

Lead the charge in managing complex energy storage projects, driving innovative solutions in renewable energy. Collaborate with multi-disciplinary teams to ensure project success from development to e...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Join a team that's optimizing procurement strategies to enhance operational efficiency across multiple projects. Leverage supplier relationships and manage negotiations to drive performance and cost s...

Reposted today

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Empower your career by leading innovative GTM engineering initiatives. Drive AI workflows, automate marketing processes, and enhance productivity across teams. Collaborate with stakeholders to transfo...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Advance clinical trial execution by leading cross-functional teams, ensuring timely delivery of innovative therapies. Collaborate with stakeholders to navigate product life cycles from concept to comm...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Drive the product metrics operating system, managing quarterly planning, release cycles, and customer feedback integration. Collaborate with product managers to ensure alignment between roadmap work a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $210K *

Drive enterprise technology strategy and innovation, aligning IT with business goals. Lead strategic planning, vendor management, and financial oversight to enhance operational performance and support...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$153K - $225K *

Drive the design and execution of impactful sales programs that enhance pipeline generation and revenue outcomes. Collaborate cross-functionally to ensure alignment and accountability, while operating...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $215K *

Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$67K - $182K *

Unlock your potential as you lead proposal development and client audit responses, ensuring clarity and compliance in complex healthcare contracts. Drive project management for implementations while c...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Transform regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability an...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Drive regional success by leading launch execution and building high-performing teams. Foster customer relationships and ensure alignment with corporate goals in a fast-paced, entrepreneurial environm...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$215K - $240K *

Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's redefining partnerships in the crypto and fintech space. You'll engage with key affiliates and networks, driving growth through live negotiations and strategic collaborations, all w...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Join our Cyber Security team to spearhead a robust application security program, collaborating with developers to secure software and mitigate vulnerabilities. Help innovate security tools while enhan...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Legal & Accounting

$85K - $100K *

Transform veterinary care by joining a dynamic team offering flexible scheduling options. Contribute to two growing hospitals, providing high-quality medical and surgical services while enjoying a sup...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$88K - $138K *

Drive cross-functional projects by translating business needs into technical requirements, ensuring successful adoption of solutions across various People Technology platforms, including Workday and T...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.