Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$200K - $250K *

Champion the evolution of fraud prevention strategies, enhancing customer experience while safeguarding against risks. Collaborate cross-functionally to design innovative solutions that balance securi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic team as you develop and maintain dealer partnerships, driving growth and enhancing customer satisfaction in the auto finance sector. Leverage your expertise to navigate market trends an...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $160K *

Elevate your career by supporting senior leaders in a dynamic tech environment. Manage complex calendars, coordinate travel, and streamline processes to enhance productivity and drive success across g...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by leading a dynamic SQA team to enhance software quality. Drive testing strategies, mentor team members, and ensure compliance with best practices while managing multiple projects in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $125K *

Analyze customer needs and drive product initiatives using AI tools. Own features from discovery to delivery, ensuring alignment with business priorities and quality outcomes while collaborating acros...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $120K *

Manage and optimize Oracle databases (11g/12c/19c) on Linux/Unix. Ensure high availability, implement backup strategies, and enhance performance through tuning and monitoring. Provide 24x7 support and...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $170K *

Join a team that's expanding strategic partnerships with consulting firms to enhance supply chain solutions. Drive growth through collaboration, relationship management, and innovative go-to-market st...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$210K - $230K *

Drive your career with a dynamic role focused on enterprise B2B sales, where you'll cultivate relationships, leverage data insights, and collaborate cross-functionally to close high-value deals in a f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $105K *

Contribute to innovative biotech solutions by leading method establishment and validation in a cGMP lab. Leverage your expertise in ELISAs and data analysis to mentor junior staff and ensure timely de...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $205K *

Drive measurable SEO results by owning key surfaces and experiments, leveraging AI tools for hands-on building, and collaborating across teams to enhance organic growth and visibility in a dynamic, re...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$141K - $196K *

Unlock potential by developing causal machine-learning models to optimize customer offers, analyzing complex data, and translating findings into actionable strategies for enhanced conversion rates acr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$168K - $232K *

Lead the charge in executing innovative financing strategies for our AI lending marketplace. Collaborate with investors and stakeholders to drive structured transactions, ensuring scalable funding sol...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Unlock potential by leading strategic partnerships and driving growth initiatives. Collaborate cross-functionally to enhance business opportunities and ensure partner success through data-driven insig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $160K *

Lead strategic life sciences accounts, driving growth and team development while ensuring project success and client satisfaction through strong relationships and innovative solutions...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $124K *

Drive impactful SAP projects as a Project Manager/Scrum Master, leading teams to deliver innovative solutions. Collaborate with stakeholders, manage product backlogs, and ensure agile practices to mee...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$250K - $300K *

Join a dynamic team as you drive enterprise sales across mid-market to Fortune 500 accounts. Own the entire sales cycle, engage multi-stakeholder buying committees, and leverage AI tools to redefine b...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $220K *

Shape the future of global accounts by aligning technical strategy with business vision. Engage with C-suite stakeholders to drive innovation, define KPIs, and integrate AI analytics into service deli...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $240K *

Drive the growth and impact of the B Corp movement in the US and Canada, leading strategic initiatives, fostering partnerships, and enhancing community engagement to position purpose-driven business a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$107K - $161K *

Join a team that's dedicated to managing complex Auto and General Liability claims. You'll handle high exposure cases, oversee litigation, and develop resolution strategies while collaborating with va...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$83K - $133K *

Optimize customer interactions by managing order entry, tracking, and support activities across local business units and agent accounts, ensuring timely delivery and effective communication in a dynam...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Champion innovation by leading bioanalytical studies, ensuring compliance and data integrity in a GLP environment. Collaborate with teams to deliver high-quality results and mentor junior scientists w...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Unlock potential by leading a transformative sales organization across diverse markets. Drive growth through strategic sales initiatives, team development, and robust forecasting, while transitioning...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Elevate design excellence by leading complex projects from inception to completion. Collaborate with clients, manage budgets, and ensure timely delivery while fostering a results-driven team environme...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$190K - $230K *

Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.