Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$144K - $210K *

Drive compliance excellence by leading a team focused on identifying and addressing control gaps and violations across financial services, ensuring adherence to regulatory standards while enhancing su...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Lead the charge in building and guiding a US technical organization, ensuring battlefield-proven products meet US defense standards while fostering collaboration with global teams to enhance customer...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$140K - $200K *

Empower mission-critical federal systems by leading the design and automation of secure cloud platforms. Drive reliability, mentor engineers, and set technical direction in a collaborative environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Support senior leaders by providing agile administrative assistance, managing complex calendars, coordinating travel, and optimizing processes to enhance operational efficiency across the organization...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$133K - $143K *

Elevate your career by developing AI algorithms and applications that drive data analysis and automation. Collaborate on innovative projects integrating Google Cloud LLMs with BigQuery to deliver acti...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$122K - $187K *

Unlock growth by driving strategic sales initiatives within assigned accounts. Collaborate with C-suite executives to deliver tailored technology solutions, ensuring exceptional customer experiences w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$89K *

Transform hotel operations by leading engineering and maintenance teams to ensure optimal facility performance, safety, and guest comfort while managing infrastructure effectively and efficiently...

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$150K - $180K *

Transform operations by leading strategic initiatives, driving growth, and enhancing customer relations across multiple departments while ensuring alignment with corporate objectives and goals...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$180K - $240K *

Join us to build and operate secure infrastructure for federal and partner environments. This hands-on role focuses on Kubernetes, infrastructure as code, and production support, ensuring reliable dep...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$108K - $130K *

Lead and grow sales across the Western U.S. for architectural products. Drive revenue, build high-performing teams, and provide technical support to ensure successful project execution and customer sa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform the banking landscape by driving sales success and building key relationships. Utilize your expertise to develop strategic solutions that meet client needs while achieving ambitious sales ta...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $240K *

Unlock innovative solutions as you build full-stack applications for federal partners, focusing on user experience, security, and seamless integrations. Collaborate with engineers and product teams to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $188K *

Engage with federal clients as a Field Engineer to ensure seamless integration of AI technology, building robust data pipelines and collaborating with cross-functional teams to drive customer success...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $132K *

Elevate the suitability review process for broker-dealer and investment adviser accounts. Analyze complex transactions, provide training, and drive process improvements while collaborating with Regist...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by driving sales growth through strategic partnerships with agents and agencies. Collaborate to develop and implement innovative marketing strategies that enhance customer service whi...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in driving revenue growth across a multistate territory by managing a team of Dealer Representatives. Oversee sales operations, strategic direction, and relationship building to achiev...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$172K - $236K *

Champion global tax reporting and compliance by leading a high-performing team, ensuring accurate financial statements, and modernizing processes through automation and technology. Collaborate with se...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$123K - $170K *

Empower customer satisfaction by managing complex programs, bridging engineering and supply chain teams, and ensuring operational excellence through effective governance and communication with enterpr...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$250K - $300K *

Lead the charge in expanding enterprise accounts by driving revenue growth, establishing executive relationships, and delivering tailored solutions that meet evolving customer needs in the rapidly gro...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $96K *

Optimize partnerships with stakeholders to drive strategic initiatives, ensuring alignment and measurable value. Foster collaboration across teams, anticipate market changes, and champion solutions th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$172K - $238K *

Champion the secured lending risk governance framework by leading a team to enhance loan salability and asset quality. Collaborate cross-functionally to ensure compliance and effective portfolio perfo...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $140K *

Discover your potential as you design and develop impactful web experiences, collaborating across teams to create engaging landing pages and brand sites that drive conversions and enhance user interac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $95K *

Unlock your potential by driving sales growth and building strong customer relationships in a dynamic remote role. Collaborate with teams to exceed quotas and KPIs while navigating the competitive lan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$94K - $122K *

Empower operational excellence by providing technical support for production systems. Lead complex projects as a subject matter expert, enhancing system performance and driving process improvements th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$95K - $115K *

Champion quality patient care by collaborating with a dedicated team of physicians and advanced practitioners in a supportive environment focused on oncology services and patient outcomes...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.