Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $140K *

Join a team that's empowering customers by providing expert guidance on cloud and server technologies. You will lead deployments, troubleshoot issues, and advocate for best practices, ensuring top-not...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $230K *

Grow strategic client relationships in South Texas through solutions-driven sales. Utilize technical expertise to address complex customer needs and expand market share while fostering long-term partn...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Shape the future of enterprise data strategy and architecture, ensuring governance, quality, and integration across the organization. Lead modernization efforts and establish standards for data manage...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Pioneer the Resident Onboarding Lift product, driving strategy and execution in partnership with AppFolio. Own the roadmap, influence product outcomes, and enhance customer experiences while collabora...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$225K - $265K *

Shape the future of secure administration by leading a dynamic engineering team focused on backend services, user access, and account management. Drive innovation while ensuring operational excellence...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$71K - $89K *

Empower a dynamic team by leading hands-on customer service efforts, coaching associates, and ensuring high-quality interactions. Drive performance and foster a supportive environment while managing r...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $162K *

Transform the suitability review process by leading a dynamic team focused on compliance, operational excellence, and continuous improvement. Collaborate across functions to ensure timely, accurate re...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$101K - $165K *

Deliver impactful compensation programs by leading project management, conducting analyses, and collaborating with cross-functional teams to enhance employee rewards and drive organizational success...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $130K *

Grow your career by managing complex multi-line claims across multiple states. Collaborate with clients and teams to develop effective resolution strategies while maintaining compliance and building s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $100K *

Champion educational excellence by overseeing district operations, leading policy development, and managing personnel. Drive strategic initiatives to enhance student achievement and ensure compliance...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $155K *

Join a team that's dedicated to driving operational excellence and project delivery. Lead a diverse portfolio, enhance agency workflows, and foster collaborative relationships across departments to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$167K - $245K *

Accelerate IT innovation by leading operations and engineering teams that enhance productivity and security for a 500+ remote workforce, while embedding AI and automation into core processes for optim...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Transform internal operations by leveraging AI to streamline workflows, enhance reporting, and drive efficiency across Finance, People, and Legal teams. Collaborate with stakeholders to identify high...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Engage with clients to optimize estate and tax planning, collaborating with internal teams to deliver exceptional service and measurable results. Lead projects from planning to implementation, ensurin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$200K - $263K *

Champion compliance excellence by leading advertising review processes, enhancing operational workflows, and implementing innovative solutions to support rapid growth while ensuring adherence to regul...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $125K *

Drive AI-powered product initiatives from strategy to execution, collaborating with engineering and design to create customer-centric solutions that enhance productivity and engagement while prioritiz...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Elevate developer engagement by representing Render at events, crafting workshops, and shaping technical direction. Drive community feedback into product enhancements while building strong relationshi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Manage patient care by performing wellness exams, medical procedures, and mentoring staff, promoting efficient client communications and high-quality treatment in a supportive and engaging environment...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $160K *

Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $120K *

Transform our proposal development process by crafting compelling narratives and presentations. Collaborate with cross-functional teams to enhance storytelling and optimize resources, ensuring our cap...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$254K - $382K *

Transform clinical research by leading strategic medical initiatives, ensuring operational excellence, and fostering collaboration across teams. Drive innovation and mentor future leaders while delive...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$126K - $188K *

Accelerate progress at the forefront of operational risk enablement, leading regional teams to implement enterprise standards, build capabilities, and foster relationships across diverse stakeholders...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform the Human Resources landscape by leading strategic initiatives that enhance colleague engagement, optimize workforce planning, and ensure operational excellence in a healthcare setting, all...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $139K *

Lead a dynamic account team to drive strategic growth and client relationships. Oversee financial management and tactical execution while fostering team development and ensuring high-level client sati...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Elevate performance creative by owning strategy, testing, and team leadership across multiple channels. Drive creative diversification and manage agency relationships to enhance customer journeys and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.