Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Implementation Engineer, Customer Support
$100K - $140K *
Join a team that's empowering customers by providing expert guidance on cloud and server technologies. You will lead deployments, troubleshoot issues, and advocate for best practices, ensuring top-not...
Reposted 1 week ago
$100K - $230K *
Grow strategic client relationships in South Texas through solutions-driven sales. Utilize technical expertise to address complex customer needs and expand market share while fostering long-term partn...
Reposted 1 week ago
$110K - $130K *
Shape the future of enterprise data strategy and architecture, ensuring governance, quality, and integration across the organization. Lead modernization efforts and establish standards for data manage...
1 week ago
Senior Product Manager, Resident Onboarding
$120K - $145K *
Pioneer the Resident Onboarding Lift product, driving strategy and execution in partnership with AppFolio. Own the roadmap, influence product outcomes, and enhance customer experiences while collabora...
1 week ago
Engineering Manager, Admin Experience
$225K - $265K *
Shape the future of secure administration by leading a dynamic engineering team focused on backend services, user access, and account management. Drive innovation while ensuring operational excellence...
1 week ago
$71K - $89K *
Empower a dynamic team by leading hands-on customer service efforts, coaching associates, and ensuring high-quality interactions. Drive performance and foster a supportive environment while managing r...
1 week ago
ESI Associate Vice President, Suitability Review
$110K - $162K *
Transform the suitability review process by leading a dynamic team focused on compliance, operational excellence, and continuous improvement. Collaborate across functions to ensure timely, accurate re...
Reposted 1 week ago
Compensation Analyst II (Programs & Partnerships)
$101K - $165K *
Deliver impactful compensation programs by leading project management, conducting analyses, and collaborating with cross-functional teams to enhance employee rewards and drive organizational success...
1 week ago
$85K - $130K *
Grow your career by managing complex multi-line claims across multiple states. Collaborate with clients and teams to develop effective resolution strategies while maintaining compliance and building s...
1 week ago
$85K - $100K *
Champion educational excellence by overseeing district operations, leading policy development, and managing personnel. Drive strategic initiatives to enhance student achievement and ensure compliance...
1 week ago
$130K - $155K *
Join a team that's dedicated to driving operational excellence and project delivery. Lead a diverse portfolio, enhance agency workflows, and foster collaborative relationships across departments to en...
1 week ago
$167K - $245K *
Accelerate IT innovation by leading operations and engineering teams that enhance productivity and security for a 500+ remote workforce, while embedding AI and automation into core processes for optim...
Reposted 1 week ago
$100K - $120K *
Transform internal operations by leveraging AI to streamline workflows, enhance reporting, and drive efficiency across Finance, People, and Legal teams. Collaborate with stakeholders to identify high...
1 week ago
$100K - $120K *
Engage with clients to optimize estate and tax planning, collaborating with internal teams to deliver exceptional service and measurable results. Lead projects from planning to implementation, ensurin...
1 week ago
Director, Advertising and Promotion Compliance
$200K - $263K *
Champion compliance excellence by leading advertising review processes, enhancing operational workflows, and implementing innovative solutions to support rapid growth while ensuring adherence to regul...
1 week ago
$100K - $125K *
Drive AI-powered product initiatives from strategy to execution, collaborating with engineering and design to create customer-centric solutions that enhance productivity and engagement while prioritiz...
Reposted 1 week ago
Staff Developer Relations Engineer
$135K - $160K *
Elevate developer engagement by representing Render at events, crafting workshops, and shaping technical direction. Drive community feedback into product enhancements while building strong relationshi...
1 week ago
$80K - $95K *
Manage patient care by performing wellness exams, medical procedures, and mentoring staff, promoting efficient client communications and high-quality treatment in a supportive and engaging environment...
Reposted 1 week ago
Sr Manager, Operational Finance
$121K - $160K *
Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...
Reposted 1 week ago
$80K - $120K *
Transform our proposal development process by crafting compelling narratives and presentations. Collaborate with cross-functional teams to enhance storytelling and optimize resources, ensuring our cap...
Reposted 1 week ago
Senior Medical Director - Oncology
$254K - $382K *
Transform clinical research by leading strategic medical initiatives, ensuring operational excellence, and fostering collaboration across teams. Drive innovation and mentor future leaders while delive...
Reposted 1 week ago
Executive Director, Enterprise Regional Enablement
$126K - $188K *
Accelerate progress at the forefront of operational risk enablement, leading regional teams to implement enterprise standards, build capabilities, and foster relationships across diverse stakeholders...
1 week ago
Executive Director of Human Resources
$110K - $130K *
Transform the Human Resources landscape by leading strategic initiatives that enhance colleague engagement, optimize workforce planning, and ensure operational excellence in a healthcare setting, all...
1 week ago
Group Account Supervisor (Media) - Healthcare and Pharmaceutical Advertising
$100K - $139K *
Lead a dynamic account team to drive strategic growth and client relationships. Oversee financial management and tactical execution while fostering team development and ensuring high-level client sati...
Reposted 1 week ago
Senior Director of Performance Creative
$150K - $180K *
Elevate performance creative by owning strategy, testing, and team leadership across multiple channels. Drive creative diversification and manage agency relationships to enhance customer journeys and...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.