Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$148K - $201K *

Transform IT services by developing strategic partnerships and delivering innovative solutions that enhance business performance and production capabilities within the Defense, Space & Security divisi...

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$88K - $109K *

Join a team that's redefining procurement strategies in a dynamic environment. Leverage your expertise in supplier management and contract negotiation to drive performance and innovation in our Precis...

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$93K - $126K *

Optimize pricing strategies and cost proposals by leveraging your expertise in estimating, financial analysis, and compliance. Collaborate with cross-functional teams to enhance accuracy and drive suc...

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Join us to manage and enhance our consumer purchase data assets, collaborating with vendors and internal teams to ensure high-quality data acquisition and compliance, driving insights and analytics fo...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$76K - $180K *

Innovate in business development by driving growth for gas piping systems. Lead strategies to enhance contractor demand and expand wholesale distribution, translating market insights into measurable r...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$57K - $108K *

Engage in innovative BIM/VDC projects, delivering precise drafting services and managing multiple tasks in a dynamic environment. Collaborate with clients to create detailed piping drawings and advanc...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$124K - $149K *

Grow your career with us as you design and enhance security infrastructure across AWS and on-premises environments, ensuring robust protection for critical workloads through innovative cloud security...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$149K - $201K *

Lead the delivery and optimization of high-performance computing services, ensuring reliability and compliance while managing client relationships and operational issues. Drive continuous improvement...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$147K - $199K *

Contribute to dynamic frontend engineering, driving strategic direction and leading the development of user-centered web applications for government clients. Harmonize technical excellence with a stro...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Information Technology

$102K - $138K *

Unlock potential by leading major incident management to enhance healthcare IT operations. Collaborate with cross-functional teams to ensure system stability and improve patient care across diverse me...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$161K - $218K *

Lead the charge in healthcare operations, ensuring program success and financial performance while collaborating with stakeholders to adapt to evolving needs. Drive high-performance teams and deliver...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $178K *

Transform enterprise identity governance by leading IGA projects, ensuring timely delivery and alignment with mission needs. Collaborate across teams to enhance security and compliance in a dynamic IC...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$79K - $108K *

Join a team that's transforming technology into opportunity by administering and governing Microsoft Power Platform environments. Leverage your expertise to enhance mission-critical projects and drive...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$97K - $115K *

Transform technology into opportunity by developing innovative SharePoint solutions. Lead the charge in enhancing user experiences and integrating Microsoft 365 services while collaborating with cross...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$113K - $154K *

Shape the future of cybersecurity by leading the modernization of critical systems. Utilize AI tools and collaborate with teams to implement robust security measures, ensuring compliance with federal...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$79K - $108K *

Optimize SharePoint environments by administering, configuring, and supporting both SharePoint Server and Online. Collaborate with teams to ensure platform health, security, and compliance while mento...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $92K *

Lead the charge in managing Safety and Compliance Committee operations, ensuring accurate records, effective onboarding, and seamless collaboration with stakeholders to uphold governance standards and...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$102K - $138K *

Lead major incident management efforts to enhance healthcare IT operations, ensuring stability and availability of critical systems. Collaborate with cross-functional teams to resolve high-severity in...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$129K - $149K *

Unlock your potential as you collaborate with teams to design and optimize cloud solutions, ensuring secure and cost-efficient operations for mission-critical projects. Drive innovation and efficiency...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$153K - $207K *

Lead the design and optimization of advanced network security architectures, focusing on Palo Alto Networks solutions. Provide senior technical leadership, drive enterprise-scale implementations, and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $178K *

Develop and support scalable microservices for enterprise systems, collaborating with product and engineering teams to ensure high-quality delivery within a cloud-native platform, while mentoring and...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $178K *

Join a team that's driving identity data management initiatives, ensuring accurate aggregation and synchronization of identity and entitlement data across diverse environments. Lead project delivery a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $189K *

Unlock potential by leading a team handling diverse Family Office clients. Drive client success through high-quality financial reporting, talent development, and collaborative processes, ensuring a su...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$85K - $100K *

Lead the charge in revenue accounting excellence, ensuring compliance with ASC 606 while driving process improvements and delivering insightful financial analyses to stakeholders across the organizati...

6 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $143K *

Elevate your career by driving loyalty solutions sales within the financial services sector. Leverage your expertise to build relationships, execute strategies, and secure multimillion-dollar deals wh...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.