Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$150K - $180K *

Innovate scalable backend systems while leading architectural design and mentoring teams. This role combines hands-on coding with strategic leadership to align technical solutions with business goals...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $176K *

Shape the future of technology partnerships by leveraging consultative selling skills, building strong alliances, and driving strategic revenue growth with senior executives across industries. Lead co...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $157K *

Empower users by driving the vision and strategy for our mobile app, enhancing customer acquisition and retention through innovative features and seamless experiences. Collaborate with cross-functiona...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$76K - $90K *

Advance team success by leading a group of researchers, ensuring quality standards, and managing client projects while fostering professional growth and collaboration across departments...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$76K - $90K *

Join a dynamic team as you lead and mentor researchers, ensuring high-quality genealogical standards while managing client projects and collaborating with leadership to enhance operational efficiency...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive compliance and optimize inventory management for strategic accounts, enhancing customer relationships through data analysis and collaboration. Lead initiatives to improve profitability and strea...

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Unlock potential by managing strategic account compliance, enhancing contract adherence, and optimizing inventory management. Collaborate with cross-functional teams to drive profitability and streaml...

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Accelerate progress at a leading organization by managing the Accounts Payable team, ensuring compliance, driving process improvements, and fostering strong vendor relationships to enhance financial o...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $153K *

Launch and optimize a cloud financial management strategy, leading the FinOps Center of Excellence to enhance cost transparency and accountability while driving multi-cloud observability to support bu...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$77K - $116K *

Transform data into actionable insights by leading BI application development, collaborating across teams, and ensuring quality reporting solutions that support strategic goals and enhance decision-ma...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$96K - $132K *

Join a team that's dedicated to transforming healthcare through innovative solutions. Collaborate with clients and experts to implement cutting-edge products, ensuring optimal workflows and exceptiona...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the development of AI-driven data solutions to optimize business operations. Collaborate with stakeholders to enhance digital transformation initiatives in underwriting and claims functions, driv...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$118K - $196K *

Lead the administration of employee equity programs, ensuring compliance and accuracy while collaborating with cross-functional teams. Drive improvements and manage vendor relationships to support sta...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $166K *

Deliver strategic workplace solutions by aligning business needs with real estate and workforce strategies. Collaborate across functions to drive integrated planning and enhance employee experience wh...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$109K - $182K *

Shape the future of rebate modeling by collaborating with cross-functional teams to optimize strategies and processes, driving value for clients and enhancing overall supply chain efficiency...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Shape integrated consumer experiences by developing client-specific strategies that align pharmacy solutions with broader initiatives, collaborating across teams to enhance value propositions and driv...

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$223K - $334K *

Lead the charge in establishing investigation excellence and reliability engineering capabilities. Collaborate globally to enhance quality outcomes, drive data-driven decisions, and mentor technical e...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$105K - $158K *

Empower clinical research by overseeing global studies, managing projects, and collaborating with stakeholders to ensure compliance and success from design to implementation. Bring your expertise to d...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $165K *

Drive growth by leading consultative sales for women's health benefits. Build relationships, tailor solutions, and close deals while managing a strong sales pipeline and collaborating with internal te...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $215K *

Unlock your potential by leading the design and optimization of enterprise load balancing solutions. Collaborate with cross-functional teams to enhance application delivery and ensure high availabilit...

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$119K - $161K *

Shape your career as a Cloud Engineer by optimizing deployment processes, managing vendor integrations, and ensuring efficient cloud operations across various environments. Drive success through innov...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$118K - $171K *

Transform enterprise learning by leading integration strategies and enhancing learner experiences. Collaborate across teams to drive operational excellence and innovation, ensuring effective learning...

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$85K - $171K *

Lead the development and deployment of Flight Termination Systems for weapons flight tests, ensuring compliance with safety standards and collaborating with diverse teams to achieve certification and...

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$85K - $140K *

Join a team that's shaping the future of aerospace by leading flight tests and evaluations for advanced weapon systems. Collaborate with industry experts to ensure safety, quality, and efficiency in d...

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$119K - $195K *

Lead the charge in developing complex cost estimates for aerospace projects, collaborating with cross-functional teams to ensure accuracy and compliance. Drive innovative pricing strategies while mana...

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.