Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$108K - $130K *

Transform electrical engineering projects by leading design and analysis from inception to completion. Collaborate with teams to deliver innovative solutions while ensuring compliance with standards a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K *

Unlock potential by driving adoption of innovative cardiovascular technology. Engage with healthcare professionals to enhance patient outcomes and satisfaction while collaborating cross-functionally t...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$245K - $270K *

Shape the future as a hands-on engineer, architecting systems and driving best practices while crafting innovative solutions that leverage AI to enhance customer value and modernize legacy platforms...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Business Services

$200K - $225K *

Drive the design and delivery of innovative AI-driven applications. Oversee the full development lifecycle, ensuring scalability and reliability in multi-tenant enterprise solutions while collaboratin...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Deliver impactful IT solutions by owning and enhancing infrastructure, systems, and processes that ensure operational integrity and security while collaborating with teams to meet business needs as th...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Lead the charge in executing strategic initiatives for a public sector subsidiary to ensure profitable growth, optimizing team performance, and aligning operations with government mandates and market...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Deliver exceptional results by driving new license revenue and renewals. Manage complex sales cycles, build strong relationships, and leverage AI tools to meet customer needs in the federal sector. Jo...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$72K - $116K *

Reimagine financial analysis by supporting Sales Incentive Plans, ensuring alignment with enrollment and financial goals. Collaborate with leaders and stakeholders to enhance accuracy, efficiency, and...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$500K+*

Accelerate your career by joining a dynamic orthopedic surgery team, leveraging subspecialty support and advanced technology to enhance patient care and drive practice growth in a thriving healthcare...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Advance clinical trial success by providing strategic expertise in operations and collaboration. Optimize processes, develop budgets, and drive initiatives to enhance efficiency while ensuring alignme...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K *

Shape the future of telecommunications by leading complex, large-scale projects. Drive strategic planning, manage executive communications, and ensure program success through innovative solutions and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$150K - $199K *

Drive the strategic direction for automated material handling systems, collaborating with experts and stakeholders to enhance logistics performance and ensure compliance with Nestlé standards while le...

6 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$182K - $337K *

Create innovative AI-native business process solutions for healthcare providers. Collaborate with stakeholders to design efficient architectures that enhance operations and drive digital transformatio...

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$65K - $100K *

Unlock potential by leading and developing teams, enhancing customer service, and driving financial performance while fostering a culture of belonging and continuous improvement in a dynamic retail en...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$83K - $133K *

Take ownership of delivering top-tier technical support and services by performing installations, maintenance, and repairs on power delivery equipment while ensuring safety standards and customer sati...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Elevate project outcomes by overseeing technology integration and management, ensuring deliverables align with quality, budget, and safety standards while fostering collaboration and leadership across...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K - $230K *

Drive exceptional patient care by delivering high-quality dental services while collaborating with a dedicated team. Embrace continuous learning and uphold the highest standards of ethics and professi...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K *

Shape the future of client success by leveraging insights and data to enhance program impact. Collaborate with leaders in law firms and professional services to drive engagement and talent development...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$157K - $189K *

Elevate your career by designing innovative digital solutions that enhance operational performance and customer experience. Collaborate across teams to translate complex business challenges into scala...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$350K *

Unlock potential by driving revenue growth through strategic relationships with enterprise customers. Engage in complex sales cycles, championing customer success while thriving in a high-performance...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Oversee capital construction projects and facility operations to enhance efficiency and safety. Collaborate with teams to ensure projects meet goals, budget, and timelines while supporting the energy...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$107K - $199K *

Lead transformative process improvements to enhance healthcare quality and efficiency. Collaborate with teams to elevate performance metrics, oversee cultural competency initiatives, and drive strateg...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $126K *

Analyze program outcomes and collaborate with stakeholders to enhance results. Manage complex projects, provide insights to leadership, and educate agencies on best practices to optimize performance a...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Optimize manufacturing capabilities by managing capital projects up to $5MM. Collaborate with cross-functional teams to ensure compliance with GMP standards and drive project success through effective...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Elevate your career by providing advanced nursing care and collaborating with physicians to enhance patient outcomes. This role involves clinical decision-making, case management, and treatment planni...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.