Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$210K - $250K *

Reimagine the future of healthcare supply chain architecture by leading modernization efforts, ensuring secure data exchange, and driving intelligent automation across systems. This role balances oper...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $97K *

Lead the charge in developing robust full-stack solutions, enhancing integrations, and ensuring secure coding practices. Collaborate in agile sprints to deliver high-quality software that meets VA sta...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Drive your career with a dynamic role focused on full-stack development, integrating REST APIs, and enhancing legacy applications while ensuring secure coding practices and compliance with accessibili...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Join a dynamic team as a Full Stack Developer, where you'll design, code, and deploy innovative solutions, ensuring high-quality software delivery through agile methodologies and secure coding practic...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Drive innovation as a Full Stack Developer, crafting robust applications and integrations. Collaborate in agile sprints to enhance VA enterprise services while ensuring secure coding practices and mai...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Develop and enhance full-stack applications, integrating REST APIs and ensuring secure coding practices. Collaborate in agile sprints to deliver high-quality software solutions while refactoring legac...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Unlock your potential as you manage complex claims, ensuring compliance and timely resolutions. Collaborate with teams, provide technical guidance, and drive performance in a fully remote role with tr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion the transition of state and local governments to modern cloud solutions. Build strategic relationships, navigate complex procurement processes, and drive measurable value through innovative t...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$114K - $166K *

Champion the execution of warranty projects by leading teams, ensuring safety, quality, and efficiency in solar site operations while collaborating with various stakeholders to resolve issues and enha...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$83K - $107K *

Shape the future of clinical education by leading Epic EMR training initiatives. Collaborate with healthcare professionals to enhance patient care through effective training programs, ensuring optimal...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $107K *

Champion innovative solutions in Epic Home Care systems to enhance clinical workflows and patient outcomes. Collaborate with leaders, mentor teams, and drive strategic initiatives in a dynamic, remote...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $120K *

Empower your career as a strategic HR Operations Manager, leading teams and driving data-informed decisions. Build effective systems, enhance performance, and deliver exceptional outcomes while foster...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $193K *

Shape the future of digital marketing by leading strategy and execution for key brands. Collaborate across teams to optimize campaigns, manage agency relationships, and drive data-informed decisions t...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $104K *

Lead the charge in enhancing customer care quality through effective monitoring, collaboration, and continuous improvement initiatives. Drive actionable insights and training to elevate service standa...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $200K *

Join a team that's redefining architectural excellence by leading global projects, driving business growth, and fostering client relationships while overseeing studio operations and strategic initiati...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in driving revenue through strategic partnerships, enhancing market reach, and delivering customer value across your designated region while managing complex sales cycles and fostering...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Accelerate progress at the forefront of digital transformation by leading strategic initiatives, ensuring effective governance, and driving organizational change across global teams to enhance program...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K *

Engage with key accounts to drive the adoption of innovative cardiovascular solutions. You will cultivate relationships with healthcare professionals, ensuring exceptional customer success and satisfa...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K *

Unlock adoption of advanced cardiovascular technologies by building strong relationships with healthcare providers, educating them on impactful solutions, and ensuring success within strategic account...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $135K *

Transform the billing and pricing landscape by driving platform strategy, enhancing user experiences, and collaborating across teams to deliver innovative solutions that meet customer needs and busine...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$97K - $139K *

Lead the charge in optimizing PostgreSQL databases for critical IT services, ensuring high availability and performance across diverse environments. Collaborate with teams to enhance system reliabilit...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $135K *

Manage the transition and steady-state phases of Client-Based Laboratories, overseeing calibration processes, training staff, and ensuring quality standards across multiple sites while maintaining str...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$98K - $138K *

Partner with us to implement advanced Appian solutions, guiding clients through design and integration while enhancing internal processes. Leverage your expertise to drive technical success and mentor...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Accelerate growth by shaping innovative marketing strategies for consumer products. Lead brand development, community engagement, and performance marketing initiatives to make blockchain accessible an...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.