Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$125K - $145K *
Lead the charge in managing key client relationships within Pharmacy Benefit Management, ensuring high-quality service delivery and client satisfaction through effective communication and consultative...
5 days ago
Team Leader - Advanced Branch Support
$95K - $115K *
Lead and develop a team of Relationship Managers, providing exceptional support and navigating complex business needs for top branch teams to enhance their service and growth...
Reposted 5 days ago
Client Security & Protocols Engineering Manager
$500K+*
Elevate security by leading a dynamic team to protect client applications across diverse platforms. Drive strategy and technical direction for foundational security capabilities, ensuring robust defen...
5 days ago
$130K - $155K *
Champion innovative data solutions by designing and maintaining robust data pipelines across Azure and Microsoft Fabric, ensuring high-quality data delivery and governance while leading engineering in...
5 days ago
$160K - $170K *
Unlock the potential of our data center maintenance strategy. Lead the development of comprehensive maintenance plans, manage vendor relationships, and ensure operational excellence across multiple si...
5 days ago
$75K - $90K *
Elevate your career by ensuring top-notch quality in technical deliverables. Collaborate with stakeholders to enhance cybersecurity documentation and support critical DoD programs while maintaining hi...
5 days ago
$150K - $180K *
Shape the future of consumer financial services by providing strategic legal guidance throughout the product lifecycle. Collaborate with cross-functional teams to ensure compliance and drive innovatio...
5 days ago
Sr. Director, No Kid Hungry State Campaigns
$135K - $155K *
Join a team that's shaping the future of state campaigns by leading strategic initiatives, fostering collaboration, and driving impactful solutions to combat hunger across multiple regions. Your exper...
5 days ago
Vice President, Medical Affairs
$280K - $325K *
Join a team that's transforming clinical evidence into impactful product strategies. Collaborate with cross-functional leaders to enhance healthcare solutions, drive innovation, and strengthen market...
5 days ago
Senior Director, Global Compensation
$233K - $500K+*
Lead the development and execution of innovative global compensation strategies, partnering with stakeholders to enhance employee engagement while ensuring compliance and effectiveness in a dynamic ma...
Reposted 5 days ago
Senior Staff Applied Scientist, Science Platform
$232K - $325K *
Join a dynamic team to lead the development of advanced analytics tools, leveraging your expertise in statistics and machine learning to drive impactful decision-making across the organization...
5 days ago
$92K - $129K *
Elevate your career by managing and optimizing our server infrastructure, ensuring security and performance. Leverage your expertise to lead initiatives and support critical IT operations in a dynamic...
Reposted 5 days ago
$97K - $146K *
Deliver impactful engineering solutions across supply chain operations, enhancing efficiency and productivity. Collaborate with teams to implement process improvements and maintain engineering standar...
5 days ago
$150K - $180K *
Unlock strategic leadership in affordable housing development, guiding a team to identify and execute multifamily projects. Drive growth by managing the development pipeline and ensuring alignment wit...
Reposted 5 days ago
$145K - $175K *
Lead the accounting operations for a fast-growing CPG business, ensuring financial integrity and compliance. Collaborate with teams to optimize processes while managing a small team and driving automa...
5 days ago
Endpoint Security Engineer III
$101K - $111K *
Design and sustain advanced endpoint security solutions for a major enterprise. Collaborate with vendors and stakeholders to enhance security capabilities, ensuring robust protection across diverse en...
5 days ago
Executive Operations Coordinator, Office of the COO
$180K - $220K *
Join a team that's redefining operational excellence by empowering the COO. You'll streamline communications, manage scheduling, and enhance productivity, enabling strategic focus and impactful decisi...
5 days ago
$135K - $160K *
Shape the future of homebuilding by leading a small team of engineers to develop innovative solutions. Balance technical ownership and people leadership while driving impactful projects from concept t...
Reposted 5 days ago
$120K - $145K *
Lead the charge in architecting and automating secure CI/CD pipelines and cloud infrastructure, ensuring compliance and resilience while delivering high-quality software through expert DevSecOps pract...
5 days ago
Managing Director - AIE & Amazon Commerce Connections Lead
$125K - $295K *
Shape the future of Amazon Commerce by leading AI-enabled solutions that transform complex data into actionable insights, driving business growth and innovation across multiple clients and sectors...
5 days ago
Head of Technology & Data Partnerships
$195K - $270K *
Transform the technology and data partnership landscape by defining and executing a strategic vision that enhances product innovation, strengthens market positioning, and drives sustainable growth thr...
5 days ago
Oracle Fusion Data Conversion Consultant (Functional and Technical)
$110K - $130K *
Engineer your career by leading Oracle Fusion data conversions from legacy systems. Collaborate with finance SMEs and AI agents to ensure accurate data mapping, error resolution, and reconciliation fo...
5 days ago
$100K - $120K *
Lead the charge in enhancing operational efficiency across Finance, HR, and Legal teams. Drive strategic initiatives, foster team development, and ensure effective communication to elevate organizatio...
5 days ago
Portfolio Manager - Commerce Trust
$137K - $214K *
Join a dynamic team to manage client portfolios, establish investment objectives, and provide tailored financial solutions. Collaborate with seasoned professionals to enhance client relationships and...
5 days ago
Philanthropy Program Manager, Vision Trips
$80K - $95K *
Champion impactful donor experiences by managing high-quality trips that connect partners with our mission. Collaborate across teams to ensure strategic alignment, enhance donor engagement, and develo...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.