Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$115K - $125K *

Grow your career with us as you drive business development in the hospitality sector. Leverage your existing network to identify opportunities, close deals, and build lasting relationships while manag...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$135K - $165K *

Transform the marketing landscape by driving product launches, shaping narratives, and executing strategies in a dynamic environment. Collaborate closely with engineers to communicate complex technolo...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$99K - $110K *

Accelerate progress at winning new enterprise customers by leveraging your expertise in complex SaaS solutions. Drive revenue growth and build executive relationships while navigating intricate sales...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$350K - $389K *

Unlock potential by providing exceptional psychiatric care in a supportive outpatient setting. Enjoy a flexible schedule, competitive compensation, and a collaborative environment focused on patient w...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$139K - $213K *

Join a team that's driving innovation in education technology by generating strategic opportunities and delivering tailored solutions to key decision-makers in the Mid-Atlantic region, ensuring except...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$56K - $125K *

Empower store operations by enhancing sales, managing team performance, and delivering exceptional customer experiences while ensuring compliance with regulations and optimizing inventory management...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $110K *

Unlock potential by leading complex projects within a dynamic ePMO, driving cross-functional alignment, and ensuring timely execution while communicating effectively with senior leadership to foster t...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Lead solar resource assessments and performance analytics for utility-scale projects. Engage with clients, optimize energy yield, and enhance methodologies while ensuring operational excellence in sol...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$95K - $115K *

Drive pharmacy operations by interpreting prescriptions and ensuring compliance with regulatory standards. Collaborate with healthcare providers and supervise staff to provide optimal medication manag...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Staffing

$138K - $159K *

Empower growth by leading our US Sales Development team, driving pipeline success and fostering a collaborative culture. You'll partner with cross-functional leaders to enhance strategy and performanc...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Advance customer service excellence by leading a dynamic team across multiple regions. Drive operational efficiency, enhance customer experience, and foster team development while collaborating on str...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$99K - $232K *

Partner with us to lead SAP S/4HANA migration projects, guiding teams and managing client expectations while optimizing technology solutions that align with business goals and drive transformation acr...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$99K - $232K *

Innovate with us to lead SAP S/4HANA migration projects, guiding teams and managing complex client needs while aligning technology solutions with business objectives and optimizing SAP environments...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$143K - $179K *

Analyze customer experiences to drive retention strategies and enhance satisfaction. Collaborate across teams to shape data-driven decisions, develop metrics, and prioritize analytics initiatives that...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $195K *

Unlock your potential by building advanced entity matching solutions. Collaborate with a dedicated team to transform complex data into actionable insights, ensuring transparency and accuracy in every...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $204K *

Join a dynamic team to enhance sales effectiveness through innovative tools, training, and strategies. Leverage industry expertise to optimize buyer interactions and drive business goals while collabo...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$86K - $143K *

Grow your career with a dynamic role managing sales operations, driving strategy, and enhancing processes to support a high-performing sales team while leveraging technology and data for continuous im...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$102K - $147K *

Join a dynamic team to drive new business opportunities with Large Enterprises, cultivating relationships with C-level executives and managing the full sales cycle to deliver exceptional client value...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $250K *

Unlock potential by leading sales initiatives in the public safety sector. Drive revenue growth, manage territory strategies, and build strong client relationships while collaborating with a dedicated...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $250K *

Help us drive growth in the public safety market by managing sales in the Northeast. You'll develop strategies, build relationships, and close deals while collaborating with a dedicated team to achiev...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of consumer science in R&D by leading product performance validation and translating consumer insights into actionable recommendations, enhancing product development processes and red...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$85K - $122K *

Empower customer experience by leading strategic initiatives and enhancing service delivery. Manage key accounts, drive process improvements, and mentor team members to ensure exceptional customer sat...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$169K - $213K *

Drive impactful relationships as a Medical Science Liaison, engaging with KOLs and healthcare professionals to support product utilization and market insights while ensuring compliance with regulatory...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to optimizing packaging solutions through strategic sourcing, supplier management, and cross-functional collaboration. Drive continuous improvement initiatives while ensur...

5 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$200K - $285K *

Champion innovation by leading technical strategy and open standards initiatives, driving interoperability in payments and protocol architecture while collaborating with diverse stakeholders to enhanc...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.