Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$112K - $141K *
Shape the future of client delivery as you oversee project execution and stakeholder collaboration, ensuring timely delivery and high quality while managing client relationships and driving project su...
Reposted 5 days ago
$111K - $144K *
Optimize product strategies and drive development from concept to launch. Collaborate with cross-functional teams to align product vision with business goals, ensuring high-quality outcomes that meet...
5 days ago
$146K - $229K *
Drive the AI roadmap and deliver secure, scalable solutions that enhance decision-making and streamline workflows. Lead teams from experimentation to production, ensuring measurable business value and...
5 days ago
$103K - $174K *
Lead the charge in engineering and procurement for electrical projects, managing design and delivery through third-party consultants. Ensure project success from bid to closeout while coordinating wit...
Reposted 5 days ago
Mid-Market Account Executive - SF based
$110K - $130K *
Join a team that's redefining security in an AI-driven world by owning the full sales cycle for mid-sized organizations. Drive growth, foster relationships, and close deals while navigating complex en...
5 days ago
Sr Manager, Empaveli Publications - US Medical Affairs
$125K - $150K *
Shape the future of scientific communications by leading global publication strategies in nephrology and hematology. Collaborate with cross-functional teams to ensure timely, high-quality deliverables...
5 days ago
Channel Partner Manager - North America
$81K - $142K *
Champion the growth of channel partnerships across North America, driving distributor performance and strategic key account sales in industrial printing solutions. Leverage market insights to enhance...
5 days ago
$100K - $120K *
Engage with clients and counsel to optimize document review processes, leveraging technology and analytics. Oversee project management, ensuring quality and efficiency while driving collaboration acro...
5 days ago
$150K - $180K *
Shape the future of stablecoin infrastructure by leading product management, driving execution, and developing a high-impact team. Collaborate closely with customers and engineering to enhance adoptio...
5 days ago
Business Excellence Program Manager
$101K - $152K *
Join a team that's driving organizational change and fostering continuous improvement. As a key player, you'll enhance operational efficiency and implement strategic initiatives across departments, en...
5 days ago
$100K - $120K *
Champion full-cycle recruiting by partnering with leaders to attract top talent, drive hiring excellence, and enhance candidate experiences in a dynamic, fast-paced environment...
5 days ago
Int Database Reliability Engineer (DBRE)
$111K - $139K *
Drive database reliability by managing and optimizing cloud-based infrastructure. Collaborate with Engineering and SRE teams to enhance performance, automate processes, and support mission-critical ap...
5 days ago
$180K - $220K *
Champion the mental health of patients by diagnosing, prescribing, and implementing treatment plans in a collaborative environment, ensuring effective care for individuals with serious mental illnesse...
5 days ago
External Communications Manager
$85K - $102K *
Develop and execute comprehensive external communications strategies to enhance brand visibility, manage digital marketing efforts, and ensure consistent messaging across channels, while collaborating...
5 days ago
Staff Software Engineer, AI Platform (US - Remote or Calgary)
$205K - $225K *
Engineer core runtime surfaces for an AI platform, overseeing system design, operation, and compliance. Collaborate with product teams to enhance functionality and reliability in a fast-paced, high-au...
Reposted 5 days ago
$168K - $210K *
Transform commercial agreements by drafting, negotiating, and closing enterprise SaaS contracts. Collaborate with cross-functional teams to ensure compliance and drive business growth while managing l...
5 days ago
Financial Institution Senior Consultant (SOX and FDICIA Controls)
$72K - $147K *
Partner with us to enhance regulatory compliance and risk management for financial institutions. Leverage your expertise in SOX and FDICIA controls while collaborating with clients to navigate complex...
Reposted 5 days ago
Talent & Workforce Consulting Manager - Life Science
$94K - $293K *
Shape the future of workforce transformation by designing AI-enabled solutions that enhance talent strategies, skills development, and organizational readiness for an evolving work landscape...
5 days ago
$188K - $245K *
Shape innovative user experiences by leading design initiatives, mentoring teams, and driving strategic solutions in a fast-paced environment. Collaborate across functions to elevate design quality an...
Reposted 5 days ago
Senior Site Reliability Engineer
$160K - $208K *
Transform our technology infrastructure by enhancing automation, troubleshooting issues, and fostering collaboration. Bring your expertise to support a scalable infrastructure platform that manages di...
Reposted 5 days ago
$75K - $90K *
Support our dynamic Accounting team by managing tax compliance and reporting. Thrive in a fast-paced environment while handling multiple projects and ensuring accuracy in financial processes. Adapt an...
5 days ago
SAP S/4 HANA Cloud-ABAP consultant
$114K - $167K *
Advance your career by leading complex ERP solutions, optimizing business processes, and driving integration strategies. Collaborate with teams to enhance system performance and ensure compliance whil...
5 days ago
$110K - $130K *
Champion strategic customer success by developing account plans, driving engagement, and enhancing product adoption. Leverage data and AI tools to foster relationships with key members and ensure thei...
Reposted 5 days ago
Territory Director / Client Services
$110K - $130K *
Join a team that's dedicated to driving client retention and growth. Lead a talented group of account managers, cultivate strategic relationships, and implement innovative solutions to achieve revenue...
5 days ago
Transaction Management Director
$175K - $220K *
Oversee a global transaction management team, driving strategic real estate initiatives and ensuring effective execution of commercial transactions while mentoring staff and enhancing operational perf...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.