Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$160K - $200K *

Drive growth and innovation by leading commercial strategies in the Media, Entertainment, and Gaming sectors. Collaborate with teams to enhance client relationships, identify new opportunities, and en...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Media

$135K - $155K *

Lead and mentor a team of data engineers to design, develop, and maintain scalable data pipelines and warehouses, collaborating with stakeholders to deliver key metrics and establish data strategy acr...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Transportation

$139K - $219K *

Empower client relationships by serving as the primary contact for the US Navy, anticipating needs and driving business growth through strategic marketing and data analysis while maintaining accurate...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$127K - $168K *

Drive impactful program management by overseeing service contracts, enhancing client relationships, and ensuring successful deployment of smart grid solutions. Collaborate with teams to meet performan...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Transform customer success by leading a high-performing team to drive value, retention, and growth across enterprise accounts. Collaborate cross-functionally to ensure operational excellence and measu...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$109K - $125K *

Optimize enterprise strategy and analytics by transforming complex data into actionable insights. Collaborate across functions to enhance decision-making and support strategic initiatives through effe...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$71K - $106K *

Deliver exceptional nursing care by assessing, planning, and implementing treatment for patients, while collaborating with a multi-disciplinary team to enhance patient satisfaction and uphold hospital...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $110K *

Shape the future of learning by leading innovative enablement programs that empower managers and new hires. Collaborate with cross-functional teams to design impactful training solutions that drive or...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $110K *

Pioneer innovative solutions as a Senior Business Systems Administrator, driving strategy and optimization across G&A and Finance systems. Collaborate cross-functionally to enhance system performance...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a team that's dedicated to enhancing patient care through internal medicine. You'll leverage your expertise while working full-time, impacting lives in a leading acute-care hospital within a supp...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform internal communications by developing strategies that engage employees, enhance leadership visibility, and strengthen organizational alignment across various channels, fostering a culture of...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive strategic growth by leading a high-performing sales team in critical care. Recruit, train, and mentor specialists to exceed revenue goals while collaborating with cross-functional teams to enhan...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $187K *

Join a dynamic team as a Senior Software Engineer, driving innovation in cloud technology. Collaborate across disciplines, mentor peers, and lead impactful projects that enhance our product suite whil...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $240K *

Transform fraud detection in healthcare by leading end-to-end investigations, coordinating legal support, and leveraging innovative technology to enhance operational integrity and compliance in our Me...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $103K *

Join a dedicated team providing after-hours clinical support, triaging patient needs, and ensuring quality care outcomes. Collaborate with interdisciplinary teams to deliver effective nursing support...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $160K *

Champion member engagement by crafting compelling campaigns that drive awareness and action. Collaborate across teams to enhance communication, utilizing AI tools to optimize outreach and improve memb...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Elevate your engineering career by leading innovative projects and driving strategic technology direction in a rapidly growing organization. Collaborate across teams to champion excellence and mentor...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's transforming early literacy by leveraging your experience in education. Collaborate with school and district leaders to build partnerships that drive student reading success and exp...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Deliver impactful project leadership by guiding cross-functional teams through all phases of clinical research, ensuring compliance, effective communication, and timely project milestones that enhance...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Unlock your potential by managing program operations, supervising staff, and enhancing patient experiences. Collaborate with cross-functional teams to drive operational excellence and ensure client sa...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Elevate healthcare delivery by providing remote GI services to Veterans. Collaborate with facility leaders to establish clinics, manage patient panels, and ensure timely access to care while adhering...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Contribute to transforming enterprise software by defining mission specifications and translating complex ERP logic into actionable agent tasks. Collaborate with cross-functional teams to enhance cust...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$86K - $103K *

Drive cybersecurity initiatives by integrating security throughout the IT development lifecycle. Collaborate on vulnerability assessments and enhance enterprise security services to protect systems an...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$85K - $100K *

Unlock potential by leading complex food service programs, ensuring operational excellence and financial success while collaborating across divisions and engaging with customers at a senior level...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$124K - $183K *

Transform lease accounting processes by ensuring accurate ASC 842 compliance, analyzing complex lease arrangements, and collaborating cross-functionally to enhance reporting efficiency and effectivene...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.