Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $110K *

Lead environmental remediation projects, ensuring safety and compliance while managing teams and client relationships. Oversee proposal preparation, cost estimates, and project execution across variou...

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$207K - $244K *

Champion product strategy and roadmap for risk management, driving cross-functional collaboration to enhance fraud detection and prevention while ensuring a seamless customer experience across platfor...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by leading a high-performing sales team, driving regional growth, and fostering collaboration across functions to enhance customer experience and achieve strategic goals...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $135K *

Help us drive success for enterprise clients by managing key accounts, offering strategic guidance, and ensuring seamless project delivery. Elevate your career by collaborating with top-tier clients i...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$192K - $353K *

Contribute to critical DoD M&S initiatives by providing operational expertise in tactical aviation. Guide development efforts to ensure mission effectiveness and advise stakeholders as a Trusted Opera...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Join a team that's shaping the future of consumer payments by designing and building scalable Angular applications. Collaborate across disciplines to create intuitive user experiences while maintainin...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Transform commercial contracts into strategic assets by leading negotiation and management of agreements in a dynamic environment, partnering closely with Sales and Customer Success teams to foster bu...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Analyze manufacturing costs and drive financial insights to enhance operational efficiency. Collaborate with cross-functional teams to ensure accurate cost management and inventory accounting, support...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic sales team, driving end-to-end enterprise sales and building lasting relationships with leading hardware companies to enhance their supply chains and technological impact...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Advance your career by leading a high-performing sales team in the luxury automotive sector. Drive operational excellence, enhance customer experiences, and implement strategic sales initiatives to ac...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$225K - $275K *

Lead the charge in redefining Total Rewards strategy, enhancing compensation, equity, and benefits to attract and retain top talent while anticipating workforce shifts driven by AI and market trends...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $100K *

Join a compassionate team of licensed psychologists diagnosing ADHD and ASD. Leverage your expertise in evaluations and foster collaboration while providing clear feedback to families and supporting c...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $230K *

Shape your career by implementing local market strategies in oncology sales. Collaborate with key stakeholders to enhance referral pathways and community engagement, driving impactful initiatives that...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$238K - $357K *

Transform security strategy as a Principal Product Manager, bridging technical expertise and customer needs. Collaborate with cross-functional teams to prioritize security features, ensuring usability...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Champion innovative data solutions by architecting scalable cloud data pipelines and lakes. Leverage deep financial services expertise to drive technical product management and ensure seamless data in...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$53K - $174K *

Lead the charge in providing exceptional US individual tax services, ensuring compliance and strategic consulting for high net worth clients. Enjoy a flexible, remote work environment with a focus on...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$157K - $205K *

Elevate your career by leading strategic operations within Medicare Advantage, leveraging analytics and AI to drive performance, align cross-functional initiatives, and provide actionable insights tha...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$163K - $203K *

Optimize enterprise-wide business continuity management by leading the development and implementation of a robust BCM framework, ensuring critical services are maintained and recovery capabilities are...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$176K - $230K *

Drive impactful healthcare innovations by leveraging data science to enhance patient outcomes. Lead projects from concept to business impact, collaborating with stakeholders and mentoring peers to del...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $120K *

Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $195K *

Drive change management initiatives that enhance employee engagement and operational efficiency. Collaborate across teams to ensure successful adoption of technology and policy changes, while providin...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $293K *

Help us lead transformative revenue cycle projects for complex healthcare organizations, optimizing patient access, mid-cycle, and back-end operations while driving measurable improvements and fosteri...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$175K - $210K *

Join a team that's redefining decentralized storage solutions, driving growth, establishing strategic partnerships, and shaping the market landscape for an innovative protocol. Your expertise will emp...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$70K - $235K *

Unlock innovative AI-driven commerce solutions by designing and implementing multi-agent systems. Collaborate with clients to ensure scalable, secure deployments that align with business objectives an...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$135K - $220K *

Engage with clients to transform business challenges into AI solutions. Collaborate in a multidisciplinary team to develop prototypes and integrate AI applications using AWS services, ensuring quality...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.