Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Environmental Project Manager, PSG
$80K - $110K *
Lead environmental remediation projects, ensuring safety and compliance while managing teams and client relationships. Oversee proposal preparation, cost estimates, and project execution across variou...
5 days ago
$207K - $244K *
Champion product strategy and roadmap for risk management, driving cross-functional collaboration to enhance fraud detection and prevention while ensuring a seamless customer experience across platfor...
5 days ago
Regional Sales Manager - Central Plains
$110K - $130K *
Unlock potential by leading a high-performing sales team, driving regional growth, and fostering collaboration across functions to enhance customer experience and achieve strategic goals...
Reposted 5 days ago
Senior Account Manager - Mobile Growth
$100K - $135K *
Help us drive success for enterprise clients by managing key accounts, offering strategic guidance, and ensuring seamless project delivery. Elevate your career by collaborating with top-tier clients i...
Reposted 5 days ago
Senior Tactical Aviation Operations Lead
$192K - $353K *
Contribute to critical DoD M&S initiatives by providing operational expertise in tactical aviation. Guide development efforts to ensure mission effectiveness and advise stakeholders as a Trusted Opera...
5 days ago
Senior Front-End Engineer (Angular)
$120K - $145K *
Join a team that's shaping the future of consumer payments by designing and building scalable Angular applications. Collaborate across disciplines to create intuitive user experiences while maintainin...
5 days ago
$120K - $145K *
Transform commercial contracts into strategic assets by leading negotiation and management of agreements in a dynamic environment, partnering closely with Sales and Customer Success teams to foster bu...
Reposted 5 days ago
$88K - $105K *
Analyze manufacturing costs and drive financial insights to enhance operational efficiency. Collaborate with cross-functional teams to ensure accurate cost management and inventory accounting, support...
Reposted 5 days ago
$110K - $130K *
Join a dynamic sales team, driving end-to-end enterprise sales and building lasting relationships with leading hardware companies to enhance their supply chains and technological impact...
Reposted 5 days ago
$100K - $120K *
Advance your career by leading a high-performing sales team in the luxury automotive sector. Drive operational excellence, enhance customer experiences, and implement strategic sales initiatives to ac...
Reposted 5 days ago
$225K - $275K *
Lead the charge in redefining Total Rewards strategy, enhancing compensation, equity, and benefits to attract and retain top talent while anticipating workforce shifts driven by AI and market trends...
Reposted 5 days ago
Licensed Psychologist - Remote
$80K - $100K *
Join a compassionate team of licensed psychologists diagnosing ADHD and ASD. Leverage your expertise in evaluations and foster collaboration while providing clear feedback to families and supporting c...
Reposted 5 days ago
Local Market Solutions Manager, CAR-T - Mid-Atlantic
$133K - $230K *
Shape your career by implementing local market strategies in oncology sales. Collaborate with key stakeholders to enhance referral pathways and community engagement, driving impactful initiatives that...
5 days ago
Principal Product Manager, Security
$238K - $357K *
Transform security strategy as a Principal Product Manager, bridging technical expertise and customer needs. Collaborate with cross-functional teams to prioritize security features, ensuring usability...
Reposted 5 days ago
Associate Technical Architect - Data - USA
$125K - $150K *
Champion innovative data solutions by architecting scalable cloud data pipelines and lakes. Leverage deep financial services expertise to drive technical product management and ensure seamless data in...
5 days ago
Tax Senior Manager- Individual Tax Services
$53K - $174K *
Lead the charge in providing exceptional US individual tax services, ensuring compliance and strategic consulting for high net worth clients. Enjoy a flexible, remote work environment with a focus on...
5 days ago
Senior Manager, Actuarial AI & Enterprise Performance
$157K - $205K *
Elevate your career by leading strategic operations within Medicare Advantage, leveraging analytics and AI to drive performance, align cross-functional initiatives, and provide actionable insights tha...
Reposted 5 days ago
Business Continuity Management Lead
$163K - $203K *
Optimize enterprise-wide business continuity management by leading the development and implementation of a robust BCM framework, ensuring critical services are maintained and recovery capabilities are...
Reposted 5 days ago
$176K - $230K *
Drive impactful healthcare innovations by leveraging data science to enhance patient outcomes. Lead projects from concept to business impact, collaborating with stakeholders and mentoring peers to del...
Reposted 5 days ago
$92K - $120K *
Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...
Reposted 5 days ago
Director, Enterprise Portfolio Management
$150K - $195K *
Drive change management initiatives that enhance employee engagement and operational efficiency. Collaborate across teams to ensure successful adoption of technology and policy changes, while providin...
Reposted 5 days ago
Health Provider Revenue Cycle Manager
$87K - $293K *
Help us lead transformative revenue cycle projects for complex healthcare organizations, optimizing patient access, mid-cycle, and back-end operations while driving measurable improvements and fosteri...
Reposted 5 days ago
Head of Enterprise GTM - Shelby Platform
$175K - $210K *
Join a team that's redefining decentralized storage solutions, driving growth, establishing strategic partnerships, and shaping the market landscape for an innovative protocol. Your expertise will emp...
Reposted 5 days ago
Technical Commerce & AI Consultant | Agentic Commerce
$70K - $235K *
Unlock innovative AI-driven commerce solutions by designing and implementing multi-agent systems. Collaborate with clients to ensure scalable, secure deployments that align with business objectives an...
Reposted 5 days ago
AI Delivery Engineer - AWS Bedrock
$135K - $220K *
Engage with clients to transform business challenges into AI solutions. Collaborate in a multidisciplinary team to develop prototypes and integrate AI applications using AWS services, ensuring quality...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.