Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$190K - $304K *

Lead the charge in shaping the future of ticketing for restaurants, driving product-market fit and commercialization strategies while collaborating closely with customers and cross-functional teams to...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$128K - $252K *

Unlock potential by leading AI strategy initiatives that drive business transformation. Collaborate with stakeholders to identify needs, prioritize use cases, and develop actionable roadmaps for AI ad...

4 days ago

  •   Less than 5 years exp.  •   Business Services

$150K - $200K *

Champion the connection between product and customer teams by designing AI-powered workflows that streamline communication, ensuring both sides are informed and responsive to changes and feedback, enh...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $140K *

Unlock potential by driving new business development in Missouri and Iowa. Engage with retail customers, implement strategic sales plans, and exceed sales goals while maintaining strong relationships...

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $220K *

Lead the development and execution of a global channel partner strategy, focusing on recruitment, enablement, and growth of VARs, MSSPs, and GSIs. Build a high-performing team to drive international e...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$102K - $180K *

Transform enterprise partnerships by driving account growth, fostering relationships, and optimizing sales processes. Collaborate with internal teams, lead post-sales management, and utilize data insi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by managing SQL server databases, ensuring performance, availability, and security. Collaborate with IT teams to troubleshoot issues, implement changes, and develop disaster recovery...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Join a team that's driving innovation by leveraging your technical expertise to lead and mentor engineers, enhance product performance, and deliver high-quality, cloud-native solutions across diverse...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Media

$80K - $100K *

Join a team that's redefining market expansion by managing and optimizing field sales programs. Drive recruitment, training, and process improvements to ensure success in newly launched markets across...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Transportation

$160K - $177K *

Lead the charge in cultivating and expanding high-value global client relationships, driving strategic account plans, and achieving exceptional sales targets in a dynamic SaaS environment...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Media

$117K - $209K *

Own and optimize the end-to-end Procure-to-Pay function, ensuring seamless operations across Procurement, Accounts Payable, and supplier management while driving governance, performance, and stakehold...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's advancing hypersonic technology by analyzing and executing ground tests. Collaborate with engineers and stakeholders to develop test plans and evaluate propulsion systems, ensuring...

4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$215K - $408K *

Grow your career with a dynamic role in behavioral health, leading medical management and quality improvement initiatives. Collaborate across diverse markets to enhance care delivery and support conti...

Missouri, USRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$171K - $326K *

Lead the charge in overseeing department staff, managing budgets, and aligning IT strategies with organizational goals to enhance operational reliability and drive continuous improvement across system...

Missouri, USRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Elevate audio ML research by designing workflows that automate experiments, enhance reproducibility, and optimize GPU resources. Collaborate with researchers to streamline processes and deliver impact...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $165K *

Transform client relationships by driving revenue growth and satisfaction in healthcare accounts. Collaborate with stakeholders to develop tailored strategies, ensuring long-term partnerships and meas...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

$96K - $101K *

Empower domestic workers by leading impactful research initiatives that inform advocacy and policy development. Drive strategic research agendas, mentor a dedicated team, and collaborate with diverse...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Partner with us to enhance patient care by providing expert drug therapy and collaborating with healthcare teams. Your role will be pivotal in ensuring safe medication practices and delivering high-qu...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $140K *

Shape the future of financial markets as an Operations Risk Analyst, ensuring the stability of trade processes, monitoring risk exposure, and collaborating across teams to enhance operational resilien...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by driving new business growth in mid-market sectors. Own the full sales cycle, from prospecting to closing, while building relationships and shaping strategies for success in a dynam...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$70K - $150K *

Elevate your career by producing engaging social media videos! Collaborate with creative teams to craft viral content, tailored for TikTok, Instagram, and YouTube. Your editing expertise will drive ca...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$119K - $140K *

Join a team that's dedicated to enhancing customer success through strategic relationships, proactive engagement, and tailored solutions. Drive product adoption and ensure satisfaction while collabora...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$285K - $335K *

Lead the charge in developing and executing commercial strategies that drive brand growth and enhance decision-making capabilities across a dynamic portfolio, focusing on oncology and market insights...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$157K - $185K *

Unlock potential by driving relationships with Fortune 500 accounts. Leverage strategic prospecting and consultative selling to deliver exceptional security solutions while managing multiple high-valu...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.