Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Specialty Sales Representative - Las Vegas & Albuquerque
$120K - $155K *
Elevate healthcare engagement by driving product adoption and brand awareness. Collaborate with healthcare professionals to deliver impactful education and build strong relationships, while navigating...
4 days ago
$70K - $400K *
Help us transform the customer experience in annuity sales by guiding clients through the buying process, ensuring clarity, and fostering trust while contributing to the development of a groundbreakin...
Reposted 4 days ago
Director of Engineering, Database Excellence
$230K - $345K *
Lead the charge in database excellence to enhance reliability, performance, and sustainability of GitLab's datastores. Shape long-range strategies while collaborating across teams to drive success in...
Reposted 4 days ago
Senior Director, Product Management, Consumer (Bottom-Funnel)
$211K - $373K *
Innovate the consumer experience by leading product strategy and execution. Drive a high-performing team to enhance onboarding and insurance purchasing while aligning with cross-functional partners to...
Reposted 4 days ago
Sr. RN Consultant - Professional Liability
$85K - $95K *
Transform complex medical malpractice claims by leveraging clinical expertise and analytical skills. Collaborate with teams to investigate, evaluate, and provide actionable insights, ensuring effectiv...
4 days ago
Senior Manager, Distribution & Revenue Strategy
$120K - $160K *
Drive strategic initiatives across partnerships, revenue, and operations. Collaborate with cross-functional leaders to tackle complex challenges in a fast-paced environment, ensuring effective executi...
Reposted 4 days ago
Intermediate Fullstack Engineer, Subscription Lifecycle
$115K - $194K *
Lead the development of fullstack features for subscription management, enhancing customer experiences and ensuring reliable billing workflows. Collaborate with cross-functional teams to deliver safe...
4 days ago
Analytics & AI Account Executive, Sales
$110K - $130K *
Elevate your career by partnering with sales teams to drive analytics and AI revenue. Leverage your expertise to accelerate deal closure, generate new opportunities, and empower field teams with strat...
4 days ago
Associate Director, Clinical Supply Chain Sourcing Strategy and Innovation
$141K - $191K *
Lead strategic initiatives in clinical supply chain sourcing, enhancing innovation and vendor optimization to support global clinical trials. Drive continuous improvement through process standardizati...
Reposted 4 days ago
Staff Engineer - Product Development (Contact Systems)
$110K - $130K *
Lead innovative product development in power connectors and cable assemblies, driving technical excellence and cross-functional collaboration to deliver high-quality solutions that meet market demands...
4 days ago
$95K - $115K *
Champion clinical trial success by leading cross-functional teams, ensuring timely project execution, and maintaining high standards of quality and compliance. Collaborate with stakeholders to drive i...
4 days ago
Sr. Corporate Compensation Analyst
$79K - $141K *
Elevate your career by supporting the design and administration of global compensation programs. Collaborate with HR and business leaders to deliver competitive, compliant solutions while managing ana...
4 days ago
Solution Architect, Forward Deployed AI
$135K - $160K *
Transform AI pilots into secure, reliable production systems by designing innovative solutions and collaborating with cross-functional teams to ensure responsible enterprise adoption of AI technologie...
4 days ago
$97K - $180K *
Unlock potential by driving accurate pricing and valuation activities for mutual funds. This role offers broad exposure to financial operations, systems, and audit support, fostering growth for future...
4 days ago
Engineering Manager, Systems Reliability Engineering
$130K - $155K *
Join a team that's redefining retail technology by leading a high-performing engineering group focused on modernizing and automating store platforms for a global audience, ensuring reliability and sca...
4 days ago
DevOps Technical Lead / Architect - Azure & Terraform
$135K - $160K *
Innovate with us to modernize a .NET insurance platform, leading a DevOps team to enhance CI/CD practices, automate infrastructure, and drive scalable architecture for improved stability and performan...
4 days ago
Actuary - Valuation & Reserving
$107K - $199K *
Analyze financial outcomes and oversee actuarial valuations. Collaborate with teams to enhance processes and communicate results effectively. Leverage advanced analytical skills to support healthcare...
4 days ago
Commissioning Senior Manager - Mechanical
$160K - $190K *
Elevate your career by leading the mechanical commissioning lifecycle for mission-critical facilities. Oversee multi-disciplinary teams, ensure compliance, and deliver projects on time and within budg...
4 days ago
Regional Field Marketing Manager (US)
$165K - $180K *
Shape the future of B2B marketing by building strategic relationships with enterprise tech leaders. Drive impactful programs that enhance customer engagement and support sales initiatives across the U...
4 days ago
Documentation Platform Engineer
$163K - $204K *
Pioneer an exceptional documentation platform that enhances user experience. Collaborate with cross-functional teams to build, maintain, and evolve tools that showcase product features, ensuring seaml...
4 days ago
Environmental Health & Safety Manager
$80K - $95K *
Champion a culture of safety and compliance by leading EHS initiatives, training, and inspections. Drive continuous improvement in environmental health and safety standards while ensuring adherence to...
4 days ago
Senior Market Leader - Renewables
$160K - $216K *
Drive business growth in the renewable market by developing innovative client solutions, mentoring teams, and collaborating across departments to meet evolving client needs and market challenges...
Reposted 4 days ago
$80K - $95K *
Join a dynamic team to enhance automation systems, troubleshoot PLCs, and lead modernization projects. Supervise production staff while driving equipment reliability and process improvements in a fast...
5 days ago
Supplier Quality Engineer- Mechanical
$95K - $115K *
Shape the future of supplier quality in mechanical engineering by overseeing the quality assurance of critical components and systems. Collaborate with suppliers to ensure compliance, execute testing...
5 days ago
Supplier Quality Engineer- Mechanical
$80K - $95K *
Take ownership of supplier quality for mechanical components, ensuring compliance from qualification through Factory Acceptance Testing. Collaborate with suppliers to uphold standards, manage inspecti...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.