Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $155K *

Elevate healthcare engagement by driving product adoption and brand awareness. Collaborate with healthcare professionals to deliver impactful education and build strong relationships, while navigating...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$70K - $400K *

Help us transform the customer experience in annuity sales by guiding clients through the buying process, ensuring clarity, and fostering trust while contributing to the development of a groundbreakin...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$230K - $345K *

Lead the charge in database excellence to enhance reliability, performance, and sustainability of GitLab's datastores. Shape long-range strategies while collaborating across teams to drive success in...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$211K - $373K *

Innovate the consumer experience by leading product strategy and execution. Drive a high-performing team to enhance onboarding and insurance purchasing while aligning with cross-functional partners to...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$85K - $95K *

Transform complex medical malpractice claims by leveraging clinical expertise and analytical skills. Collaborate with teams to investigate, evaluate, and provide actionable insights, ensuring effectiv...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $160K *

Drive strategic initiatives across partnerships, revenue, and operations. Collaborate with cross-functional leaders to tackle complex challenges in a fast-paced environment, ensuring effective executi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $194K *

Lead the development of fullstack features for subscription management, enhancing customer experiences and ensuring reliable billing workflows. Collaborate with cross-functional teams to deliver safe...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by partnering with sales teams to drive analytics and AI revenue. Leverage your expertise to accelerate deal closure, generate new opportunities, and empower field teams with strat...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$141K - $191K *

Lead strategic initiatives in clinical supply chain sourcing, enhancing innovation and vendor optimization to support global clinical trials. Drive continuous improvement through process standardizati...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead innovative product development in power connectors and cable assemblies, driving technical excellence and cross-functional collaboration to deliver high-quality solutions that meet market demands...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Champion clinical trial success by leading cross-functional teams, ensuring timely project execution, and maintaining high standards of quality and compliance. Collaborate with stakeholders to drive i...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $141K *

Elevate your career by supporting the design and administration of global compensation programs. Collaborate with HR and business leaders to deliver competitive, compliant solutions while managing ana...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Transportation

$135K - $160K *

Transform AI pilots into secure, reliable production systems by designing innovative solutions and collaborating with cross-functional teams to ensure responsible enterprise adoption of AI technologie...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$97K - $180K *

Unlock potential by driving accurate pricing and valuation activities for mutual funds. This role offers broad exposure to financial operations, systems, and audit support, fostering growth for future...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $155K *

Join a team that's redefining retail technology by leading a high-performing engineering group focused on modernizing and automating store platforms for a global audience, ensuring reliability and sca...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$135K - $160K *

Innovate with us to modernize a .NET insurance platform, leading a DevOps team to enhance CI/CD practices, automate infrastructure, and drive scalable architecture for improved stability and performan...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$107K - $199K *

Analyze financial outcomes and oversee actuarial valuations. Collaborate with teams to enhance processes and communicate results effectively. Leverage advanced analytical skills to support healthcare...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Elevate your career by leading the mechanical commissioning lifecycle for mission-critical facilities. Oversee multi-disciplinary teams, ensure compliance, and deliver projects on time and within budg...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$165K - $180K *

Shape the future of B2B marketing by building strategic relationships with enterprise tech leaders. Drive impactful programs that enhance customer engagement and support sales initiatives across the U...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $204K *

Pioneer an exceptional documentation platform that enhances user experience. Collaborate with cross-functional teams to build, maintain, and evolve tools that showcase product features, ensuring seaml...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Champion a culture of safety and compliance by leading EHS initiatives, training, and inspections. Drive continuous improvement in environmental health and safety standards while ensuring adherence to...

4 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$160K - $216K *

Drive business growth in the renewable market by developing innovative client solutions, mentoring teams, and collaborating across departments to meet evolving client needs and market challenges...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a dynamic team to enhance automation systems, troubleshoot PLCs, and lead modernization projects. Supervise production staff while driving equipment reliability and process improvements in a fast...

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $115K *

Shape the future of supplier quality in mechanical engineering by overseeing the quality assurance of critical components and systems. Collaborate with suppliers to ensure compliance, execute testing...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Take ownership of supplier quality for mechanical components, ensuring compliance from qualification through Factory Acceptance Testing. Collaborate with suppliers to uphold standards, manage inspecti...

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.