Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $140K *

Contribute to the development of a modern platform by building features, connecting systems, and improving data usability. Engage with stakeholders and troubleshoot to deliver reliable software as par...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Staffing

$135K - $238K *

Elevate customer experiences by designing and developing cutting-edge AI-driven bot applications. Collaborate with teams to deliver innovative solutions, manage strategic projects, and leverage advanc...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$240K *

Lead enterprise cybersecurity and infrastructure initiatives, advising executive leadership on risk management and technology investments. Shape policies and governance to ensure a secure, resilient t...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Shape the future of pricing strategy by leading deal governance and commercial frameworks. Collaborate across teams to enhance pricing effectiveness and support ARR growth while guiding complex deal s...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $90K *

Launch your design career by creating user-driven experiences and collaborating with cross-functional teams. Develop wireframes, prototypes, and polished UI while growing your skills in a dynamic envi...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$168K - $283K *

Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Provide comprehensive endodontic care in a growing practice, ensuring high clinical standards and effective communication with patients and providers. Collaborate with a dedicated team to enhance pati...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Help us optimize healthcare data processes by designing and managing robust data pipelines. You'll integrate legacy systems into a unified platform, ensuring data quality and operational efficiency in...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$177K - $221K *

Optimize patient access by leading cross-functional initiatives, managing operational priorities, and driving accountability for results in a dynamic healthcare environment. Collaborate with stakehold...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$97K - $162K *

Unlock your potential by designing scalable backend systems for mission-critical geospatial applications. Collaborate with cross-functional teams to enhance data processing and real-time analytics in...

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$84K - $142K *

Join a team that's redefining enterprise database solutions, collaborating with clients to design and implement robust geospatial data management strategies. Leverage your expertise to enhance workflo...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$243K - $304K *

Transform the future of data integration by leading product strategy for our database connectors. Collaborate with engineering and sales teams to drive impactful product decisions that enhance analyti...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Join a team that's shaping developer experiences by creating impactful tutorials, demo apps, and tools. Collaborate across departments to enhance adoption and usability of Render's products while test...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$106K - $246K *

Transform manufacturing processes by designing and optimizing SAP S/4HANA solutions. Collaborate with cross-functional teams to enhance production planning, quality management, and compliance, ensurin...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Drive comprehensive Oracle Cloud ERP solutions by architecting client strategies, managing cross-functional teams, and ensuring alignment with business goals. Lead project delivery, stakeholder engage...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Engineer scalable Salesforce solutions to optimize go-to-market operations, enhancing automation, territory management, and integrations for a rapidly growing sales organization. Collaborate with stak...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$174K - $220K *

Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join our dynamic team to lead client relationships and drive account growth across diverse industries. Utilize your strategic expertise to manage complex insurance programs, provide tailored solutions...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $125K *

Join a team that's dedicated to delivering exceptional client experiences through the implementation of cloud-based software. Collaborate with diverse teams to drive project success and enhance client...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$231K - $265K *

Unlock potential by executing security operations, identifying threats, and developing automation to enhance incident response and security posture, while collaborating with cross-functional teams to...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Elevate your career by owning the video production process from concept to publish. Lead a team to enhance quality and engagement, targeting security and IT leaders while driving audience growth acros...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Empower your career by transforming business needs into innovative Salesforce solutions. Collaborate with cross-functional teams to deliver enterprise cloud technology, ensuring seamless user experien...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $215K *

Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$92K - $153K *

Join a dynamic team to architect and develop innovative Salesforce solutions, transforming business needs into scalable applications. Collaborate with stakeholders to enhance enterprise capabilities a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Elevate brand visibility and engagement by managing PR agency partnerships, developing internal communications strategies, and ensuring consistent messaging across channels to strengthen organizationa...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.