Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Software Engineer - Data Focused
$130K - $140K *
Contribute to the development of a modern platform by building features, connecting systems, and improving data usability. Engage with stakeholders and troubleshoot to deliver reliable software as par...
Reposted 5 days ago
Principal AI Solutions Architect, Customer Success
$135K - $238K *
Elevate customer experiences by designing and developing cutting-edge AI-driven bot applications. Collaborate with teams to deliver innovative solutions, manage strategic projects, and leverage advanc...
5 days ago
Vice President of Information Security and Infrastructure
$240K *
Lead enterprise cybersecurity and infrastructure initiatives, advising executive leadership on risk management and technology investments. Shape policies and governance to ensure a secure, resilient t...
5 days ago
$110K - $130K *
Shape the future of pricing strategy by leading deal governance and commercial frameworks. Collaborate across teams to enhance pricing effectiveness and support ARR growth while guiding complex deal s...
Reposted 5 days ago
$80K - $90K *
Launch your design career by creating user-driven experiences and collaborating with cross-functional teams. Develop wireframes, prototypes, and polished UI while growing your skills in a dynamic envi...
Reposted 5 days ago
Senior Advisor, Clinical Science (remote)
$168K - $283K *
Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...
Reposted 5 days ago
$180K - $220K *
Provide comprehensive endodontic care in a growing practice, ensuring high clinical standards and effective communication with patients and providers. Collaborate with a dedicated team to enhance pati...
5 days ago
$180K - $220K *
Help us optimize healthcare data processes by designing and managing robust data pipelines. You'll integrate legacy systems into a unified platform, ensuring data quality and operational efficiency in...
5 days ago
Associate Director, Project Management, Patient Support Program Operations
$177K - $221K *
Optimize patient access by leading cross-functional initiatives, managing operational priorities, and driving accountability for results in a dynamic healthcare environment. Collaborate with stakehold...
5 days ago
Software Development Engineer II - Back-End (Mission-Focused | ArcGIS)
$97K - $162K *
Unlock your potential by designing scalable backend systems for mission-critical geospatial applications. Collaborate with cross-functional teams to enhance data processing and real-time analytics in...
5 days ago
Technical Consultant- Enterprise Data Engineer
$84K - $142K *
Join a team that's redefining enterprise database solutions, collaborating with clients to design and implement robust geospatial data management strategies. Leverage your expertise to enhance workflo...
5 days ago
Staff Product Manager, Databases
$243K - $304K *
Transform the future of data integration by leading product strategy for our database connectors. Collaborate with engineering and sales teams to drive impactful product decisions that enhance analyti...
5 days ago
$135K - $160K *
Join a team that's shaping developer experiences by creating impactful tutorials, demo apps, and tools. Collaborate across departments to enhance adoption and usability of Render's products while test...
5 days ago
SAP Manufacturing Consultant (PP/QM/EHS) - 100% onsite in St. Louis, MO
$106K - $246K *
Transform manufacturing processes by designing and optimizing SAP S/4HANA solutions. Collaborate with cross-functional teams to enhance production planning, quality management, and compliance, ensurin...
Reposted 5 days ago
Oracle Cloud ERP Solution Architect
$120K - $145K *
Drive comprehensive Oracle Cloud ERP solutions by architecting client strategies, managing cross-functional teams, and ensuring alignment with business goals. Lead project delivery, stakeholder engage...
5 days ago
$110K - $130K *
Engineer scalable Salesforce solutions to optimize go-to-market operations, enhancing automation, territory management, and integrations for a rapidly growing sales organization. Collaborate with stak...
5 days ago
Staff Engineer Cloud Scalability
$174K - $220K *
Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...
Reposted 5 days ago
Howden Middle Market - Health & Benefits Account Executive (Wichita, KS)
$80K - $95K *
Join our dynamic team to lead client relationships and drive account growth across diverse industries. Utilize your strategic expertise to manage complex insurance programs, provide tailored solutions...
Reposted 5 days ago
$100K - $125K *
Join a team that's dedicated to delivering exceptional client experiences through the implementation of cloud-based software. Collaborate with diverse teams to drive project success and enhance client...
5 days ago
Staff Security Engineer - SecOps & Threats
$231K - $265K *
Unlock potential by executing security operations, identifying threats, and developing automation to enhance incident response and security posture, while collaborating with cross-functional teams to...
Reposted 5 days ago
$125K - $150K *
Elevate your career by owning the video production process from concept to publish. Lead a team to enhance quality and engagement, targeting security and IT leaders while driving audience growth acros...
5 days ago
$100K - $120K *
Empower your career by transforming business needs into innovative Salesforce solutions. Collaborate with cross-functional teams to deliver enterprise cloud technology, ensuring seamless user experien...
5 days ago
Regional Sales Director - Memphis
$180K - $215K *
Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...
Reposted 5 days ago
Salesforce Developer (Software Engineering)
$92K - $153K *
Join a dynamic team to architect and develop innovative Salesforce solutions, transforming business needs into scalable applications. Collaborate with stakeholders to enhance enterprise capabilities a...
5 days ago
$80K - $95K *
Elevate brand visibility and engagement by managing PR agency partnerships, developing internal communications strategies, and ensuring consistent messaging across channels to strengthen organizationa...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.