Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Technology Solutions - Principal
$170K - $213K *
Lead strategic partnerships and enterprise growth in veterinary tech. Drive collaboration across PIMS and ISV platforms, shaping integration and co-marketing strategies while optimizing revenue throug...
3 days ago
Chief Financial Officer (CFO) CenterPointe Hospital of Columbia
$150K - $180K *
Shape the future of financial leadership by overseeing all fiscal operations, ensuring compliance, and driving strategic initiatives to achieve operational goals in a dynamic healthcare environment...
3 days ago
$80K - $95K *
Champion technical excellence and mentor our surveying team while leading projects from inception to completion. Drive growth through innovative practices and enhance our capabilities in the land surv...
4 days ago
$88K - $105K *
Lead impactful air quality projects by evaluating emissions, preparing compliance reports, and guiding clients through regulatory processes. Collaborate with a skilled team to enhance sustainability a...
4 days ago
Physical Therapist Traveler - Nationwide
$87K - $100K *
Join a team that's dedicated to delivering exceptional patient care nationwide. As a Full-Time Internal Traveler Physical Therapist, you'll leverage your skills across diverse clinics while enjoying t...
4 days ago
$115K - $120K *
Empower cybersecurity excellence by developing and maintaining policies that align with federal standards. Collaborate with stakeholders to ensure compliance and enhance governance within a dynamic te...
4 days ago
$76K - $93K *
Manage and optimize leave and accommodation programs, ensuring compliance with regulations while providing expert guidance on complex cases. Collaborate with HR and legal teams to enhance employee exp...
4 days ago
Senior Pharmacy Sales Executive - Specialty
$84K - $145K *
Lead the charge in driving specialty pharmacy sales by engaging with healthcare providers, analyzing market trends, and influencing prescription routing to enhance patient care and increase revenue...
4 days ago
Vice President, Chief Actuary - Asset Protection
$275K - $350K *
Elevate your career by leading actuarial oversight for asset protection products. Drive pricing, underwriting, and risk strategies while collaborating across teams to ensure financial performance and...
4 days ago
Director, Rapid Response & Thought Leadership (Remote)
$170K - $260K *
Transform the cybersecurity landscape by leading rapid-response marketing initiatives and strategic thought leadership programs. Drive impactful narratives and engage cross-functional teams to address...
4 days ago
Managing Director, OneStream Consulting Practice
$202K - $346K *
Pioneer strategic growth and operational excellence in our OneStream consulting practice. Lead business development, enhance client relationships, and cultivate a high-performing team to deliver excep...
4 days ago
Senior Manager, Engineering - Onboarding
$217K - $264K *
Lead and optimize the engineering team to enhance customer onboarding and lifecycle management, ensuring robust risk management and compliance across products while fostering a high-performing, inclus...
Reposted 4 days ago
$142K - $213K *
Accelerate product development by translating business needs into technical specs. Collaborate with tech teams to ensure ad capabilities meet standards, driving innovation in digital advertising and e...
4 days ago
Electrical Engineer - Power Generation
$95K - $115K *
Explore a dynamic role supporting electrical engineering across renewable and thermal assets. Collaborate on system protection, safety, compliance, and operational reliability while driving innovative...
4 days ago
Assistant Chief Nursing Officer
$80K - $95K *
Champion exceptional nursing care by overseeing daily operations in a dynamic post-acute rehab unit. Collaborate with a dedicated team to enhance resident outcomes and foster a compassionate environme...
4 days ago
$117K - $158K *
Unlock potential by leading complex client engagements, ensuring timely delivery, budget management, and effective resource utilization while navigating challenges in a dynamic environment. Empower te...
Reposted 4 days ago
Senior Security Operations Engineer
$120K - $145K *
Join our team to enhance security operations, engineering controls, and automating responses. You'll lead incident response, manage security tools, and collaborate across teams to ensure a robust defe...
4 days ago
Finance Manager, Corporate Development
$135K - $150K *
Lead financial strategy for M&A initiatives, driving capital deployment and presenting insights to the Board. Collaborate with cross-functional teams to optimize performance and ensure successful inte...
4 days ago
$85K - $100K *
Unlock potential by serving as a clinical partner, bridging technology and practice. Engage with healthcare professionals to enhance workflows and ensure successful implementation of advanced medical...
4 days ago
$129K - $253K *
Champion automation excellence by leading a team to design and implement robust automation strategies, ensuring reliability and security across systems while driving innovation in cloud and applicatio...
Reposted 4 days ago
Staff Engineer II - Transportation
$80K - $95K *
Unlock potential by supporting the design and delivery of innovative roadway projects. Collaborate with a dynamic team to enhance community infrastructure while gaining valuable mentorship and technic...
4 days ago
$80K - $95K *
Lead the charge in advancing environmental health and safety initiatives. Collaborate across teams to implement EHS management systems, drive improvements, and foster a safety-focused culture while en...
4 days ago
Sr. Content Strategist, Comms, Selling Partner Communications & Content
$113K - $160K *
Innovate seller communications by leading editorial initiatives and enhancing content strategy. Collaborate with cross-functional teams to establish best practices and improve seller experience throug...
4 days ago
Bilingual Clinical Contact Center Supervisor
$60K - $111K *
Join a team that's dedicated to excellence in call center operations, overseeing staff performance and ensuring high-quality service delivery while fostering a culture of teamwork and continuous impro...
4 days ago
$85K - $105K *
Join our team to drive client success for mid-market RIAs. You'll manage relationships, ensure adoption, and facilitate growth through strategic guidance and training, all while collaborating with cro...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.