Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$171K - $269K *

Engineer cutting-edge machine learning algorithms and models, collaborating across teams to integrate AI functionalities into products. Drive innovation and ensure AI's transformative potential is rea...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$178K - $232K *

Innovate by developing cutting-edge machine learning algorithms and models. Collaborate with cross-functional teams to enhance AI functionalities across products, driving impactful solutions and impro...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead the configuration and support of Epic applications, ensuring seamless integration and optimal performance. Collaborate with teams to enhance workflows, troubleshoot issues, and drive project succ...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead EMR strategy and manage vendor relationships to drive operational excellence. Oversee the EMR Solution Specialist team, ensuring compliance and quality in system procedures while enhancing EMR su...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $120K *

Champion safety excellence on large-scale construction projects by ensuring compliance with safety standards, leading onsite personnel, and fostering a culture of safety among teams and subcontractors...

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$137K - $182K *

Lead the charge in transforming customer experience analytics by partnering with CX leadership to develop actionable insights, scalable reporting, and strategic analytics solutions that drive business...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$99K - $129K *

Drive operational reliability for critical financial systems, enhancing automation and infrastructure across multiple Scrum teams. Collaborate to ensure seamless processing and support business growth...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the strategy and development of digital publishing products, enhancing workflows and user experiences. Collaborate across teams to create a cohesive ecosystem that supports efficient content mana...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$93K - $150K *

Empower operational excellence by leading pilot implementations, engaging with customers, and translating insights into scalable solutions. Drive measurable outcomes while navigating complex environme...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Innovate healthcare solutions by leading product strategy for health plans. Collaborate with executives to design competitive offerings, ensuring alignment with market needs and operational execution...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$101K - $126K *

Drive clinical excellence by managing Prior Authorizations and Drug Utilization Reviews. Collaborate with healthcare providers to enhance patient care and optimize therapeutic interventions while ensu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $98K *

Join us to lead product management for our Medicare Part D program, ensuring compliance with CMS regulations while enhancing processes and client satisfaction. Your expertise will drive operational ex...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate member health through tele-pharmacy by developing clinical programs, providing outreach, and collaborating with healthcare teams to enhance care coordination and adherence to medication guidel...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $216K *

Shape the future of air traffic management by integrating modern display technology for the FAA. Collaborate with experts to enhance safety and efficiency in the National Airspace System through innov...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $216K *

Drive the modernization of air traffic management systems by integrating data and display technologies. Collaborate with FAA teams to enhance safety and efficiency in the National Airspace System thro...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $216K *

Partner with us to enhance the National Airspace System by ensuring timely upgrades and installations. Collaborate with FAA and vendors to implement cutting-edge technology, ensuring safety and effici...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$66K - $106K *

Transform organizational communications by crafting clear, concise technical documents and managing SharePoint resources. Collaborate with teams to ensure quality and consistency in messaging while su...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$104K - $166K *

Shape the future of database management by supporting and enhancing DB2 environments. Leverage your expertise in administration, troubleshooting, and SQL development to ensure optimal performance acro...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$146K - $234K *

Unlock potential by leading system integration efforts for government cloud services. Drive planning, implementation, and optimization of solutions while collaborating with cross-functional teams to e...

2 days ago

  •   15+ years exp.  •   Aerospace & Defense

$220K - $245K *

Tackle financial strategy and analysis for a leading Wellbeing business. Collaborate with leadership to enhance member engagement and operational efficiency, driving growth through insightful financia...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$165K - $210K *

Transform retail sales strategies and lead a dynamic team to achieve revenue goals. Drive account management, develop talent, and collaborate with cross-functional teams to enhance product offerings a...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$180K - $207K *

Innovate AI and ML systems as a Principal Architect, collaborating with teams to design agentic architectures and scalable solutions. Drive production delivery while shaping standards and best practic...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate customer insights by analyzing complex data to drive retention strategies. Collaborate with senior leaders to present actionable recommendations that enhance customer experience and operationa...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $120K *

Unlock potential by engaging with warm leads and delivering exceptional customer experiences. Join a dynamic team that values self-motivation and offers comprehensive training, competitive commissions...

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Drive transformational growth by managing critical customer relationships and partnerships. Leverage AI insights to shape enterprise strategies, influence executive decisions, and mentor sales profess...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.