Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
SAP Data Migration Senior Manager - Retail
$132K - $302K *
Transform enterprise data migration strategies for S/4HANA, leading complex implementations and mentoring teams. Engage with stakeholders to ensure data quality and governance while driving successful...
2 days ago
$74K - $102K *
Join a team that enhances engineering data management by driving data integrity and system improvements across Engineering, IT, and Business units, ensuring operational excellence and supporting trans...
Reposted 2 days ago
Regional Sales Director- Southeastern US Region
$120K - $160K *
Transform regional sales dynamics by leading an energetic team in the Southeast US, focusing on driving sales initiatives, coaching representatives, and enhancing brand visibility across various HVAC...
Reposted 2 days ago
$110K - $145K *
Drive impactful SAP training initiatives, ensuring end-users are equipped with essential skills for effective SAP S/4HANA utilization. Lead the development and execution of training strategies aligned...
2 days ago
$66K - $115K *
Design and develop innovative security systems using CAD software. Collaborate with engineers to create precise models and drawings that meet technical and regulatory standards, ensuring practical imp...
2 days ago
Facilities Services Manager - Academic Campuses
$88K - $105K *
Lead your career by overseeing facility operations and construction projects across a large academic campus. Foster teamwork and professional growth while managing high-performing teams to ensure oper...
2 days ago
Transmission Line Project Engineer (Central) - Remote
$100K - $166K *
Elevate your career by leading high-voltage transmission line projects. Collaborate with multidisciplinary teams to deliver innovative engineering solutions while ensuring quality and safety standards...
2 days ago
Information Technology Specialist (Information Security)
$85K - $102K *
Lead the charge in enhancing cybersecurity operations by conducting risk assessments, coordinating incident responses, and developing policies to safeguard data integrity and support international tra...
2 days ago
$160K - $175K *
Join a team that's driving sales growth by leading a dynamic sales force, implementing strategic initiatives, and enhancing customer experiences across a diverse product range in a fast-paced environm...
2 days ago
Global Site Activation Manager
$79K - $170K *
Optimize global site activation processes to enhance efficiency and compliance. Collaborate with cross-functional teams to ensure timely project delivery while maintaining high-quality standards and f...
2 days ago
$160K - $175K *
Accelerate progress at driving sales growth by leading a dynamic team, implementing strategic initiatives, and enhancing customer experiences across multiple product categories in a high-impact region...
2 days ago
$150K - $160K *
Elevate your legal career by driving commercial contracting and negotiations. Collaborate with sales and stakeholders to enhance processes and policies, ensuring scalable legal support in a dynamic en...
2 days ago
$160K - $175K *
Drive sales growth by leading a dynamic team, implementing strategies, and leveraging technology to enhance customer experience and market penetration in a key region...
2 days ago
$88K - $105K *
Unlock potential by managing air quality projects, ensuring compliance with regulations, and guiding clients through emissions evaluations and sustainability reporting while mentoring a skilled team o...
2 days ago
Systems Engineer-Cryptographic
$120K - $145K *
Champion the enhancement of cryptographic platforms, driving system integration and automation while preparing for industry changes. Collaborate with teams to optimize workflows and manage engineering...
2 days ago
$120K - $160K *
Advance HR technology by leading Workday administration, ensuring optimal system performance, security, and data governance. Collaborate with HR and IT to deliver solutions that enhance business proce...
Reposted 2 days ago
$126K - $137K *
Drive innovation by designing and developing mobile applications that enhance user experiences. Collaborate across the software lifecycle to deliver high-quality solutions, leveraging modern technolog...
2 days ago
$110K - $130K *
Join a team that's driving commercial success by leading a U.S.-based account management team, optimizing strategies, and enhancing stakeholder engagement to achieve business objectives and foster reg...
Reposted 2 days ago
Clinical Specialist, Peripheral Nerve Stimulation (PNS) - Springfield, MO
$76K - $114K *
Join a dynamic team to provide clinical support and training for innovative neuromodulation therapies. Collaborate with sales to enhance patient care and ensure successful product utilization, while m...
Reposted 2 days ago
$116K - $210K *
Elevate the quality of healthcare technology by leading test strategy and execution for a modernized EHR system. Collaborate with teams to ensure compliance, validate requirements, and enhance user ex...
2 days ago
$82K - $149K *
Unlock potential by providing logistics expertise for critical Air Force systems. Collaborate with multi-disciplined teams to optimize resource flow, manage international shipments, and ensure success...
2 days ago
$75K - $95K *
Grow your career by providing exceptional PM&R services in collaboration with an interdisciplinary team. Help enhance patient independence and quality of life at a dedicated rehab center, focusing on...
Reposted 2 days ago
AVP, Private Markets Technical Accounting
$100K - $150K *
Engineer complex fund relationships by leading technical accounting and administration for closed-end private equity and real estate. Collaborate with stakeholders to ensure accurate reporting and com...
2 days ago
$100K *
Grow your career with a dynamic sales role focused on lead generation, client retention, and exceeding targets. Enjoy a competitive earning potential and comprehensive benefits while building a profit...
2 days ago
Chief Clinical Innovation Officer
$313K - $431K *
Unlock your potential by leading clinical innovation and transformation. Collaborate with diverse teams to enhance care delivery, optimize practices, and drive measurable improvements in quality and p...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.