Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Empower your career by driving strategic partnerships and revenue growth. Collaborate with leadership to implement alliance strategies, enhance partner relationships, and promote ADP's value propositi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$129K - $161K *

Lead the charge in implementing and optimizing data protection solutions, collaborating with customers to enhance their Cohesity infrastructure. Utilize your technical expertise to resolve challenges...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Empower ecommerce brands to leverage AI marketing tools effectively, guiding users to understand and implement solutions that enhance their growth strategies while fostering confidence in AI capabilit...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Support organizational growth by driving change management, leadership development, and talent acquisition initiatives. Collaborate with leaders to enhance employee relations and optimize HR processes...

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$88K - $105K *

Join us to provide expert technical support for radiology applications, ensuring seamless operations and minimal disruptions. Collaborate with clinical teams to enhance imaging workflows and maintain...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Champion strategic initiatives by managing program lifecycles, collaborating across departments, and driving operational excellence to enhance Security outcomes and foster strong partnerships with lea...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Join a team that's transforming healthcare technology by aligning IT strategies with organizational goals, managing demand, and ensuring seamless delivery of innovative solutions to enhance patient an...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $225K *

Drive strategic growth by enhancing partnerships within the senior living sector. Lead a team to optimize provider performance, boost retention, and elevate customer satisfaction, ensuring families ha...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$98K - $109K *

Join a team that's dedicated to optimizing IT operations and ensuring compliance. You'll manage daily IT tasks, support security initiatives, and collaborate on maintaining audit readiness, all while...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K *

Join a team that's dedicated to building homes and communities by leading construction operations. This executive role drives strategic growth, budget management, and team development while ensuring p...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$162K - $225K *

Join a team that's shaping the future of fintech through M&A, fundraising, and strategic projects. Collaborate with executives to drive impactful decisions and build corporate development capabilities...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $141K *

Champion advanced security initiatives by leading Red Team efforts to identify vulnerabilities and enhance protection across enterprise systems through penetration testing and adversarial emulation, w...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$135K - $180K *

Elevate your career as a strategic HR leader, driving talent initiatives and organizational effectiveness across a large retail network while partnering with senior executives to enhance business outc...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$125K - $200K *

Shape the future of healthcare by leading value-based care initiatives, managing client engagements, and driving strategic recommendations that enhance quality and reduce costs. Collaborate with diver...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Lead strategic sales initiatives in the SLED sector, driving revenue growth and building executive relationships. Manage complex sales cycles, mentor junior staff, and represent the company at industr...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the origination and management of ESOP lending relationships, ensuring comprehensive client support, deal structuring, and strategic business development in the commercial banking sector...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's shaping the future of large-scale data center design. Leverage your civil BIM expertise to develop and coordinate complex models, ensuring seamless integration of infrastructure and...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$181K - $226K *

Join a team that's redefining release management by building efficient processes that enhance collaboration between product and engineering. You'll drive operational excellence and ensure timely produ...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $130K *

Join a dynamic team as a strategic marketing partner, driving growth and market positioning for office advisory services through innovative strategies and compelling narratives...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$206K - $257K *

Lead the charge in developing and mentoring a high-performing engineering team, driving collaboration across product and design to enhance our software solutions while fostering a culture of inclusion...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Lead staffing operations by directing recruiting activities and ensuring compliance. Develop metrics for process improvement and manage the recruitment budget while enhancing the employment brand and...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$400K - $500K *

Innovate operational excellence by leading global delivery strategies, enhancing client outcomes, and driving profitability. Collaborate with executive teams to shape a scalable, AI-enabled organizati...

United StatesRemote

2 days ago

  •   15+ years exp.  •   Enterprise Technology

$87K - $115K *

Optimize warehouse operations by implementing WMS solutions. Collaborate with teams to enhance workflows, lead testing, and ensure successful deployments, driving efficiency and scalability in logisti...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Transportation

$95K - $115K *

Champion large-scale event production by leading strategic initiatives, managing budgets, and collaborating with clients to create impactful experiences that align with their objectives and engage aud...

2 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Lead the charge in innovative mechanical design for large-scale power plants, driving projects from concept to completion. Collaborate with a dynamic team to enhance energy solutions and ensure projec...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.