Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$159K - $287K *

Drive growth and lead strategic partnerships as you oversee P&L performance and business strategy for key global accounts, ensuring operational excellence and customer satisfaction while managing high...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Transform the learner experience by owning business and functional requirements for custom LMS and LCMS platforms. Drive modernization and compliance while collaborating with cross-functional teams to...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$116K - $140K *

Advance your career as you lead transformative Oracle solutions, architecting scalable designs that drive business value. Collaborate with clients and teams to deliver innovative strategies across HCM...

2 days ago

  •   8 - 10 years exp.  •   Business Services

$273K - $380K *

Take ownership of building innovative enterprise partnerships that embed financial solutions in leading platforms. Drive strategic deals, capitalize on your industry network, and structure first-of-a...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$122K - $261K *

Lead the charge in architecting comprehensive SAP data migration strategies for S/4HANA transformations. Drive success through hands-on execution, mentoring teams, and engaging with stakeholders to en...

2 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Shape the future of cloud applications by developing scalable modules and enhancing legacy systems. Collaborate with teams to ensure high-quality code and optimize performance within an Agile framewor...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$118K - $140K *

Join a dynamic team to oversee the implementation and support of enterprise solutions, ensuring quality control and project management excellence while collaborating with clients on technical deployme...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $180K *

Empower engineering teams to innovate advertiser tools, driving technical strategy and delivery while enhancing user experience across self-service and managed workflows in a dynamic ad tech environme...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Take ownership of field operations, leading construction projects through all phases while ensuring quality, safety, and profitability. Collaborate with teams to tackle challenges and maintain schedul...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$166K - $200K *

Lead the charge in delivering comprehensive mental health services, overseeing clinical operations and team management to enhance patient care and operational efficiency within a dynamic healthcare en...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$170K - $200K *

Lead and innovate within the Field Medical Affairs team, driving strategic alignment and operational excellence. Foster collaboration and scientific integrity while mentoring a high-performing team to...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $170K *

Elevate your career by partnering with divisional leadership to drive financial strategy, enhance operational efficiency, and ensure accurate financial reporting within a dynamic SaaS environment. Mak...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $195K *

Join a team that's redefining Medicaid operations. Lead a high-performing team, drive compliance, and enhance rebate management processes while ensuring client satisfaction and operational excellence...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $140K *

Optimize risk management processes by providing guidance, ensuring compliance, and enhancing audit quality. Lead projects and develop policies to support assurance practitioners while fostering teamwo...

2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$165K - $227K *

Unlock your potential as you develop cutting-edge AI algorithms for real-time audio processing. Collaborate with experts to enhance audio experiences through innovative source separation techniques an...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$90K - $110K *

Empower clinical excellence by leading a team of Care Guide RNs while managing a caseload of active members. Drive performance, coaching, and quality metrics in a hybrid role that blends leadership wi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $196K *

Transform model validation processes by leveraging advanced analytics and AI technologies. Collaborate across teams to ensure compliance and enhance performance in a dynamic environment focused on Nat...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$113K - $146K *

Empower innovation by leading the design and implementation of advanced technology solutions. Collaborate with teams to enhance operational efficiency, automate processes, and improve user experiences...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$160K - $220K *

Join us to lead and expand our Analytics practice, driving data insights and marketing strategies while managing a talented team in a dynamic and evolving digital landscape...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Media

$160K - $220K *

Join a team that's shaping the future of analytics by developing innovative strategies and leading a high-performing team. Drive data-informed decisions and enhance marketing measurement across variou...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Media

$100K - $120K *

Advance patient care by collaborating with healthcare teams to ensure safe, effective medication therapy. Serve as a drug information resource, support clinical initiatives, and contribute to high-qua...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Join a mission-driven care community as you provide high-quality, patient-centered care in skilled nursing facilities. Enjoy unmatched schedule flexibility and a competitive compensation package desig...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $100K *

Champion new business growth by identifying and converting prospects into clients. Own the full sales cycle, leveraging data insights and consultative selling to drive urgency and deliver tailored sol...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Staffing

$133K - $188K *

Unlock potential by leading the design and implementation of enterprise-scale AI solutions on AWS, ensuring secure and scalable architectures while collaborating with engineering teams in a regulated...

2 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.