Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$125K - $150K *

Unlock potential by leading social commerce strategies across platforms like TikTok, Instagram, and YouTube. Drive revenue growth and optimize customer experiences through innovative, data-driven appr...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading development initiatives in healthcare technology, focusing on SYNON and AS400 systems. Collaborate with teams to deliver high-quality solutions for pharmacy benefits and cl...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Transform financial operations by leading accounting, reporting, and FP&A. Drive efficiency through AI integration, manage audits, and build scalable processes while supporting strategic growth initia...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$180K - $215K *

Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$215K - $240K *

Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$158K - $248K *

Unlock potential by architecting scalable file management solutions, integrating distributed systems, and ensuring secure access for enterprise customers. Collaborate across teams to enhance data acce...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$172K - $269K *

Lead and modernize global security operations, managing a distributed team while enhancing detection strategies and incident response. Drive AI integration for efficiency and ensure accountability thr...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$179K - $280K *

Shape the future of product marketing by leading a dynamic team focused on innovation, market resonance, and compelling narratives to drive product adoption and growth in a fast-paced environment...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in creating innovative software solutions in telehealth, collaborating closely with tech leadership and product teams. Drive impactful developments and own projects from inception to d...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$253K - $342K *

Join a team that's redefining pricing and packaging strategies to drive customer value and profitable growth. Lead cross-functional collaboration and influence key decisions that shape the future of m...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the administration of diverse ETFs, ensuring compliance and accuracy while mentoring a team. Collaborate cross-functionally to enhance operational processes and support fund operations in a dynam...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $110K *

Collaborate with cross-functional teams to manage ETF fund administration, ensuring compliance with SEC regulations while preparing financial statements and regulatory filings. Adapt to evolving prior...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $207K *

Develop and document global accounting processes, support SAP S/4HANA implementation, and ensure compliance with accounting standards while collaborating with cross-functional teams to enhance financi...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $207K *

Lead the charge in transforming global finance processes by documenting, testing, and validating SAP S/4HANA implementations. Collaborate with cross-functional teams to ensure compliance and optimize...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $150K *

Empower a safe work environment by leading industrial hygiene projects, ensuring compliance, and fostering team growth. Utilize your expertise to address health and safety issues while mentoring staff...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$180K - $200K *

Elevate your career by driving growth strategies that enhance lead generation for multiple brands. Collaborate with cross-functional teams to optimize acquisition channels and improve conversion rates...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Help us shape the future of infrastructure by leveraging your cost estimating expertise in a collaborative, multi-disciplinary team, empowering positive community impact through precise project contro...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Technical Services

$190K - $215K *

Elevate your career by leading the development of AI-enabled Medical Information strategies. Drive high-quality responses, oversee scientific content, and collaborate cross-functionally to ensure laun...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $161K *

Shape the future of power systems engineering by leading advanced studies, consulting, and technology initiatives. Collaborate with utilities and industry organizations to tackle complex challenges an...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $120K *

Take ownership of client onboarding by guiding users through configuration, data migration, and training while collaborating across teams to ensure seamless implementation and long-term partnership su...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$186K *

Unlock potential by leading the design and delivery of innovative risk systems, optimizing fraud detection and mitigation processes, and mentoring engineers to enhance operational excellence in a dyna...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in optimizing our Epic systems as a Senior Application Advisor, guiding a dedicated team in enhancing patient access and delivering exceptional service to clients while fostering colla...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Take ownership of the product lifecycle for a cutting-edge SaaS platform, leading cross-functional teams to define strategy, prioritize features, and ensure successful product launches that align with...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.