Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$120K - $150K *

Transform the delivery landscape by leading cross-functional initiatives, mentoring analysts, and driving strategic solutions across business units and external partners. Engage deeply in project exec...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $104K *

Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$188K - $265K *

Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$113K - $155K *

Champion quality excellence by executing business programs across manufacturing sites, collaborating with cross-functional teams to enhance product standards, manage consumer insights, and drive conti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$214K - $309K *

Unlock potential by leading the design and implementation of advanced identity solutions for AI agents. Collaborate across teams to build scalable frameworks and drive technical excellence in a dynami...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$200K *

Drive technical excellence by translating creative visions into actionable plans. Oversee pre-production, CAD drafting, and on-site execution, ensuring projects are delivered safely, on time, and with...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$180K - $220K *

Lead the charge in transforming identity security marketing strategies, driving growth and market leadership. Oversee a dynamic team to enhance product positioning, execute go-to-market plans, and sha...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$95K - $125K *

Transform safety culture by leading project teams in compliance and incident prevention. Develop safety plans, conduct audits, and facilitate training to ensure a safe work environment on large constr...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $157K *

Engineer innovative power system models and analyses to optimize utility-scale solar and storage solutions, working collaboratively with global teams to ensure compliance and advance SMA's technical c...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$164K - $240K *

Lead global procurement initiatives, optimizing sourcing strategies and cost structures to ensure high-quality products at competitive prices, while enhancing supply chain efficiencies and aligning wi...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$164K - $240K *

Lead strategic procurement initiatives to achieve optimal cost structures and maintain supply continuity. Collaborate across teams to drive innovation in sourcing and enhance quality standards while a...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$124K - $138K *

Shape the future of vendor relations by managing the RTV process, negotiating effectively, and collaborating cross-functionally to maximize recovery value and streamline operations within the supply c...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$137K - $185K *

Elevate procurement strategies by analyzing supplier performance and collaborating cross-functionally to ensure material availability and operational efficiency, driving continuous improvement in supp...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$180K - $200K *

Drive the future of AI capability by leading the development of role-specific tools and workflows, ensuring measurable impact and adoption across teams. Collaborate with HR to enhance learning and ope...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$138K - $200K *

Drive the strategic direction of enterprise security infrastructure, leading teams to design, implement, and optimize security solutions across on-premises, cloud, and hybrid environments while ensuri...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$92K - $139K *

Drive exceptional customer success by managing a complex portfolio of Enterprise accounts, enhancing software value through strategic relationships and problem-solving. Influence industry revenue and...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Accelerate progress at building a world-class AI Receptionist partner ecosystem, driving revenue and customer success through strategic enablement programs. Collaborate cross-functionally to enhance p...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Elevate patient care by diagnosing illnesses, prescribing treatments, and coordinating health plans. Collaborate with healthcare teams to ensure comprehensive patient assessments and promote health th...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join our team as a Senior Customer Success Engineer, where you'll tackle complex technical challenges, mentor peers, and enhance processes to elevate customer success across our product portfolio...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$105K - $150K *

Transform your career by joining a dynamic team focused on enhancing security compliance for cloud services. Leverage your expertise in IT security to assess architectures, guide vendors, and ensure a...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$210K - $256K *

Unlock potential by leading strategic payment modernization efforts, managing client relationships, and delivering complex digital solutions while collaborating across teams to enhance operational eff...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$73K - $102K *

Join a dynamic team to enhance software solutions through coding, testing, and collaboration. Contribute to design discussions, maintain code quality, and ensure seamless transitions to new applicatio...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to enhancing patient care through empathetic pharmacy consulting, medication management, and operational excellence. Lead pharmacy staff, ensure compliance, and improve pa...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Empower patients through expert pharmacy consulting and clinical services. Manage pharmacy operations, enhance patient experiences, and lead staff development while ensuring compliance with regulation...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.