Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$150K - $250K *

Lead the charge in driving sales and building relationships within the roofing industry. As a key liaison, you'll connect with contractors and clients to promote GAF's residential products, ensuring s...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$212K - $318K *

Shape the future of patient-centered outcomes in oncology by leading global strategies for clinical assessments and patient experience data, ensuring impactful evidence generation and regulatory succe...

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Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $182K *

Manage clinical monitoring activities for multiple trials, providing mentorship and oversight to CRAs. Collaborate with teams to ensure compliance and quality, while addressing site-level issues and e...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Unlock potential by bridging technical radio frequency capabilities with US Air Force needs. Collaborate with engineering and business teams to demonstrate and support advanced communication solutions...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $140K *

Support the U.S. Marine Corps by bridging technical radio capabilities with defense needs. Collaborate with engineering teams to demonstrate and evaluate advanced communication systems in diverse oper...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $140K *

Join a team that's redefining tactical communications for defense applications. Leverage your engineering expertise to bridge technical capabilities with USSOCOM requirements, supporting innovative so...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$71K - $99K *

Join a team that's dedicated to enhancing clinical practices through effective IT solutions. This role involves training, system maintenance, and collaboration with healthcare professionals to optimiz...

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Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower client success by managing complex health plan accounts and fostering trusted relationships with stakeholders, ensuring optimal outcomes while navigating challenges in a dynamic healthcare env...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$119K - $149K *

Innovate with us to shape the future of mobile experiences. As a Senior Mobile Engineer, you'll drive the development of high-quality iOS applications, collaborating across teams to ensure performance...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$83K - $107K *

Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Champion client engagement delivery by leading teams, managing workflows, and ensuring financial performance. Collaborate with senior leaders to enhance client relationships and drive practice growth...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$105K - $125K *

Champion continuous improvement initiatives to enhance operations through data analytics and engineering methodologies. Drive performance in safety, quality, and cost, while managing impactful project...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Transportation

$115K - $125K *

Lead transformative customer insights initiatives, integrating complex data to enhance marketing strategies. Shape data processes and develop analytical solutions to empower decision-making and drive...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Transportation

$90K - $100K *

Join a team that's redefining telecommunications by providing expert Tier 3 and 4 support, engineering, and deployment for cutting-edge voice solutions. Collaborate with peers and mentor junior member...

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Yesterday

  •   8 - 10 years exp.  •   Transportation

$105K - $130K *

Unlock potential by driving sales growth in a defined territory through strategic relationship management and promotion of genetic diagnostic testing services to healthcare professionals and instituti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's enhancing third-party risk management by leading strategic oversight, driving program improvements, and collaborating with stakeholders to ensure compliance and effective risk mitig...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$98K - $127K *

Partner with us to enhance organizational effectiveness by guiding staff engagement, career development, and strategic decision-making. Collaborate across teams to foster a culture of growth and suppo...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitality & Recreation

$130K - $140K *

Drive complex initiatives in life insurance and annuities, leveraging deep expertise to manage projects across teams and vendors. Ensure alignment with client goals while implementing AI-driven soluti...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Drive cybersecurity excellence by supporting the Tactical Assault Kit's security efforts. Collaborate with teams to integrate security best practices, enhance compliance, and tackle real-world securit...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$112K - $179K *

Unlock innovative cloud solutions by designing and governing enterprise architectures on AWS and Azure. Collaborate with cross-functional teams to ensure compliance, optimize performance, and lead clo...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Aerospace & Defense

$104K - $166K *

Lead and execute comprehensive penetration testing assessments to identify and remediate security vulnerabilities across applications, networks, and cloud environments, while providing technical guida...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Transform enterprise file transfer operations by leveraging your expertise in IBM Sterling and Unix/Linux systems. Drive efficiency and security in a critical financial services environment while coll...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Lead strategic sourcing and procurement for Defense and Health sectors, managing a team to drive supplier value, cost savings, and compliance while supporting growth and operational excellence across...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$104K - $166K *

Unlock potential by leading complex software development for Medicare claims processing. Collaborate in an Agile environment, ensuring high-quality solutions while mentoring team members and driving t...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Aerospace & Defense

$104K - $166K *

Drive the development and execution of a comprehensive testing strategy, enhancing Agile practices and automation to improve quality outcomes across complex healthcare systems while collaborating with...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.