Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,063
Sr. Finance Transformation Manager (Remote)
$145K - $220K *
Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...
Yesterday
$80K - $95K *
Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...
Yesterday
Consulting Solution Architect - NetApp
$121K - $170K *
Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...
Yesterday
Senior Consulting Data Engineer - Snowflake
$105K - $150K *
Champion your career as you lead data engineering initiatives, ensuring successful project implementation and high client satisfaction. Collaborate with teams to transform analytics data into actionab...
Reposted yesterday
Senior Education Consultant - Google Workspace
$91K - $128K *
Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...
Yesterday
Senior Manager, Digital Clinical Operations
$136K - $181K *
Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...
Reposted yesterday
Director, Global Regulatory Project and Submission Management
$176K - $236K *
Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...
Yesterday
Manager, Global Supply Chain Capabilities
$114K - $154K *
Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...
Yesterday
Director, Oncology Program Management
$178K - $238K *
Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...
Yesterday
$97K - $165K *
Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...
Reposted yesterday
Sr Microsoft Solutions Architect
$121K - $206K *
Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...
Reposted yesterday
Security Engineer - DLP and Insider threat
$105K - $149K *
Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...
Reposted yesterday
Area Director, Franchise Performance (Virginia/North Carolina)
$99K - $117K *
Lead strategic commercial initiatives to enhance performance and profitability across a portfolio of franchised hotels. Collaborate with stakeholders to drive revenue growth, optimize market share, an...
Reposted yesterday
Senior Sales Analytics Manager
$115K - $135K *
Drive impactful sales analytics by developing methodologies that enhance performance insights, forecasting, and strategic planning. Collaborate with stakeholders to translate complex data into actiona...
Yesterday
$115K - $175K *
Advance market share by driving strategic growth initiatives within the US Mid-Market and Enterprise carrier segments. Lead a high-performing team to execute regional plans, leveraging deep telecom ex...
Yesterday
$150K - $250K *
Lead the charge in driving sales and building relationships within the roofing industry. As a key liaison, you'll connect with contractors and clients to promote GAF's residential products, ensuring s...
Yesterday
Director, Patient Centred Outcomes
$212K - $318K *
Shape the future of patient-centered outcomes in oncology by leading global strategies for clinical assessments and patient experience data, ensuring impactful evidence generation and regulatory succe...
Yesterday
Lead Clinical Research Associate
$121K - $182K *
Manage clinical monitoring activities for multiple trials, providing mentorship and oversight to CRAs. Collaborate with teams to ensure compliance and quality, while addressing site-level issues and e...
Yesterday
Business Development Engineer (BDE), US Air Force
$100K - $140K *
Unlock potential by bridging technical radio frequency capabilities with US Air Force needs. Collaborate with engineering and business teams to demonstrate and support advanced communication solutions...
Yesterday
Business Development Engineer (BDE), US Marine Corps
$100K - $140K *
Support the U.S. Marine Corps by bridging technical radio capabilities with defense needs. Collaborate with engineering teams to demonstrate and evaluate advanced communication systems in diverse oper...
Yesterday
Business Development Engineer (BDE), USSOCOM
$100K - $140K *
Join a team that's redefining tactical communications for defense applications. Leverage your engineering expertise to bridge technical capabilities with USSOCOM requirements, supporting innovative so...
Yesterday
IT Clinical Informaticist - Dental Support
$71K - $99K *
Join a team that's dedicated to enhancing clinical practices through effective IT solutions. This role involves training, system maintenance, and collaboration with healthcare professionals to optimiz...
Yesterday
Customer Success Manager (Remote)
$80K - $95K *
Empower client success by managing complex health plan accounts and fostering trusted relationships with stakeholders, ensuring optimal outcomes while navigating challenges in a dynamic healthcare env...
Reposted yesterday
$119K - $149K *
Innovate with us to shape the future of mobile experiences. As a Senior Mobile Engineer, you'll drive the development of high-quality iOS applications, collaborating across teams to ensure performance...
Yesterday
Digital Marketing Strategist III - Digital Analytics, SEO/GEO and Content Strategy Lead
$83K - $107K *
Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...
Reposted yesterday
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.