Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$110K - $130K *

Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$145K - $215K *

Elevate your career by managing key accounts in the rare disease sector. Drive sales, build relationships with healthcare professionals, and ensure compliance while achieving ambitious territory goals...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$211K - $285K *

Lead the charge in late-phase oncology clinical development, collaborating across teams to design and deliver impactful results. Provide expertise in clinical trial science and data analysis, ensuring...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $141K *

Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $194K *

Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Elevate your career by driving sales and education for innovative healthcare solutions. In this role, you'll manage accounts, build relationships with healthcare professionals, and enhance patient car...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$89K - $120K *

Drive collaboration across teams to coordinate scientific data, streamline processes, and enhance operational efficiency. This role requires strong judgment and the ability to manage cross-functional...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$143K - $194K *

Advance your career by driving GEO strategy and operations, coordinating cross-functional efforts, and optimizing digital marketing initiatives for a global brand portfolio in a dynamic and collaborat...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower healthcare transformation by educating Integrated Delivery Networks on EHR systems. Collaborate with cross-functional teams to enhance patient management and care delivery through innovative h...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Empower healthcare professionals by driving product demand and managing accounts. Collaborate with teams to address client needs and exceed sales goals in a dynamic environment focused on rare disease...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $150K *

Drive branch operations by leading teams to achieve financial goals, enhance customer service, and implement strategic initiatives. Collaborate across departments to optimize performance and foster a...

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$105K - $150K *

Champion your career as you lead data engineering initiatives, ensuring successful project implementation and high client satisfaction. Collaborate with teams to transform analytics data into actionab...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$91K - $128K *

Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$136K - $181K *

Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $236K *

Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.