Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$100K - $120K *

Transform the employee experience by leading impactful HR initiatives, managing events, and enhancing organizational culture. Collaborate across teams to drive engagement, support leadership developme...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $165K *

Elevate your career by driving strategic acquisitions and value creation in a dynamic environment. Collaborate with cross-functional teams to identify targets, lead transactions, and build frameworks...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$248K - $461K *

Grow your career with us by providing strategic medical leadership for oncology agent development, coordinating clinical strategies, guiding trials, and collaborating with international experts to dri...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$82K - $115K *

Transform the academic landscape by leading faculty development and student engagement. Drive excellence in teaching and support strategies while managing faculty performance and fostering a collabora...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $154K *

Shape the future of financial crimes compliance by leading complex programs that enhance operational efficiency and regulatory adherence. Collaborate with cross-functional teams to drive strategic ini...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$253K - $298K *

Transform AI infrastructure by leading engineering efforts, driving innovation, and ensuring operational excellence across shared services. Collaborate with cross-functional teams to enhance security...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform digital growth strategies by overseeing website, SEO, and campaigns. Drive content distribution, partner marketing, and harness AI for analytics, ensuring effective buyer engagement and meas...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $210K *

Unlock the potential of Workday solutions by leading implementations, configuring systems, and ensuring client satisfaction. Collaborate with teams to document requirements, support data conversions...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Join a team that's driving operational excellence in a fast-paced fulfillment center. Lead daily operations, enhance productivity, and foster talent development while ensuring customer satisfaction an...

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$325K - $400K *

Join a team that's driving revenue growth in Northern California by leading a high-performing sales organization, developing strategic partnerships, and executing innovative go-to-market strategies in...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $157K *

Shape the future of commercial banking by leading strategic implementations, optimizing client operations, and advising on best practices to enhance financial institution capabilities and drive long-t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$130K - $160K *

Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $215K *

Innovate backend infrastructure for AI security, ensuring compliance and risk assessment. Collaborate in a dynamic environment, enhancing scalability and security while shaping the future of cybersecu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$177K - $301K *

Develop and lead strategic client growth initiatives, fostering executive relationships and aligning teams to drive long-term value, retention, and measurable outcomes across a portfolio of enterprise...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in optimizing a fast-growing credit card portfolio, driving customer acquisition, engagement, and rewards economics while collaborating with partners and engineering teams to enhance p...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Drive impactful product launches and marketing strategies in healthcare, managing therapy lines from execution to analysis. Collaborate cross-functionally to enhance provider engagement and optimize p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$240K - $330K *

Champion the development of onboard software for autonomous vehicles, leading cross-functional teams to ensure a robust software foundation. Drive strategic vision, quality, and operational excellence...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Transportation

$130K - $160K *

Drive strategic payment partnerships, enhancing user experiences through collaboration and execution of initiatives. Leverage expertise in fintech to manage relationships and align stakeholders, ensur...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$140K - $175K *

Transform the landscape of Physical AI by leading technical design and delivery of innovative systems that integrate computer vision, robotics, and digital twin technologies, ensuring seamless operati...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$146K - $224K *

Elevate clinical development by leading the strategy for biopharma platforms. Drive product lifecycles, collaborate with cross-functional teams, and ensure compliance while transforming workflows into...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $120K *

Shape the future of cybersecurity by delivering real-time incident response and analysis. Collaborate with a dynamic team to protect organizations from sophisticated threats while enhancing your skill...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $140K *

Drive impactful growth by mapping industrial markets, evaluating acquisition targets, and building investment models. Collaborate on live transactions to shape strategic decisions that enhance manufac...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.