Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$120K - $145K *

Champion the management of mainframe outsourcing, ensuring optimal performance and vendor accountability while providing technical leadership and support for mainframe technologies across the organiza...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $145K *

Develop innovative full stack applications to enhance legal operations and compliance. Collaborate with cross-functional teams to deliver secure, scalable solutions using modern technologies and cloud...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Join a team that's delivering innovative IT solutions to enhance factory operations. Contribute to effective service delivery, ensuring infrastructure and security are aligned with business objectives...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Drive program success by coordinating cross-functional teams, managing reporting, and optimizing engagement strategies for a global enterprise account, ensuring alignment with client goals and employe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$280K - $300K *

Drive new business growth by leveraging innovative automation solutions. Build lasting client relationships and serve as a trusted advisor in the Agentic Process Automation space, while exceeding sale...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$195K - $250K *

Lead the charge in defining and executing energy strategies for new markets, ensuring sustainable power infrastructure aligns with growth objectives. Collaborate with stakeholders to unlock capacity a...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$196K - $270K *

Join a team that's driving innovation in the MSSP ecosystem. Lead technical strategy, engage with partners, and shape the future of security solutions across North America while fostering deep relatio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $220K *

Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $123K *

Engage in leading a dynamic team to enhance global cloud infrastructure operations. Drive strategic initiatives, mentor talent, and ensure optimal performance in data center management while participa...

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Help us drive growth by identifying and closing automation opportunities. Collaborate with technical teams to deliver tailored solutions, build lasting customer relationships, and exceed sales targets...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Champion security excellence by leading complex Microsoft Sentinel and Defender XDR implementations. Drive technical enablement projects, mentor engineers, and enhance client security practices in a d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$119K - $186K *

Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Optimize federal reporting processes by translating complex specifications into actionable business rules. Collaborate with technical teams to ensure compliance and accuracy in workforce development p...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$115K - $140K *

Shape the future of payroll management by leading certified payroll processing and union remittance. Drive compliance, accuracy, and team development while collaborating across departments to ensure t...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$100K - $120K *

Unlock the potential of enterprise learning by leading a dynamic training function. Collaborate with cross-functional teams to design and implement effective onboarding and development programs that a...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Analyze cloud cost optimization challenges, partnering with customers to enhance FinOps services. Work closely with sales and product teams, utilizing deep Azure expertise to drive actionable insights...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$128K - $192K *

The Workday Financials Senior Principal Consultant, Record to Report is a seasoned professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday Financi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$290K - $305K *

Pioneer enterprise sales in Florida, driving value-based solutions for large organizations. Collaborate with cross-functional teams to exceed targets, utilizing strategic partnerships to enhance growt...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $185K *

Unlock potential by leading business development efforts within the Air Force, focusing on Enterprise Cloud, Nuke & NC3, or AOCs/C2. Drive contract execution, build relationships, and manage a growing...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Partner with us to build a scalable sales operations framework across the Americas, enhancing forecast accuracy and pipeline management while fostering strong relationships with field leadership and d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in automating and scaling network infrastructure across diverse global datacenters, enhancing performance and security while collaborating with engineering teams to implement robust so...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$165K - $175K *

Reimagine payroll and people operations by ensuring accurate, timely compensation and benefits. Lead policy development and system improvements while supporting new and existing organizations in their...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Empower provider accounts post-launch by driving growth through strategic engagement, tailored training, and effective collaboration with internal teams. Cultivate relationships across diverse healthc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the creation and enhancement of high-quality technical documentation, collaborating with cross-functional teams to translate complex information into user-friendly content that improves the overa...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Shape the future of technology as a senior technical leader, driving complex initiatives and mentoring engineers. Collaborate with cross-functional teams to deliver scalable, secure cloud-native solut...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.