Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$165K - $195K *

Join a dynamic biotech team to drive strategic initiatives, manage cross-functional operations, and lead business development efforts. Leverage your scientific expertise and leadership skills to shape...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$165K - $200K *

Deliver exceptional user experiences by refining complex tools into intuitive designs. Collaborate closely with engineers to enhance UX, ensuring our LLM platform meets user needs with responsiveness...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive customer support excellence by managing a frontline team to ensure timely resolutions, operational efficiency, and a culture of continuous improvement, paving the way for stellar service in heal...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$86K - $149K *

Unlock your potential as a key technical leader, ensuring optimal performance of critical systems in a dynamic data center environment. Collaborate with teams to enhance operations, drive efficiency...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$114K - $191K *

Lead the charge in shaping high-impact SaaS solutions by driving technical strategy and empowering a high-performing engineering team. Collaborate across disciplines to foster innovation in a fast-pac...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $175K *

Lead community engagement initiatives to enhance patient advocacy for Becker Muscular Dystrophy. Collaborate with local organizations, educate patients, and build networks to ensure access to quality...

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Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a dynamic team to deliver innovative design engineering solutions for power projects. Leverage your expertise in mechanical engineering to create impactful designs and ensure project success thro...

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Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $125K *

Advance business growth by fostering relationships and crafting innovative strategies that drive revenue. Collaborate across teams to identify opportunities and enhance operational excellence while en...

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Reposted today

  •   Less than 5 years exp.  •   Business Services

$105K - $255K *

The Senior Account Executive at Justworks is responsible for expanding the user base and driving significant growth by managing a complete end-to-end sales pipeline. This role requires a proven closer...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Business Services

$83K - $163K *

Accelerate your career by managing a full sales cycle, from prospecting to closing deals. Engage with the entrepreneurial community and drive revenue growth while building lasting relationships in you...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$85K - $103K *

As an Account Executive in-territory in Miami, you will be responsible for managing the full sales cycle, including building and managing a sales pipeline, prospecting, and closing deals. This role re...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Partner with us to enhance relationships with executive partners, enabling pipeline growth and revenue generation. Leverage cross-functional collaboration while managing multiple engagements, driving...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform client engagement by driving growth in untapped markets, shaping impactful solutions, and delivering measurable results. Collaborate with diverse teams to connect client needs with innovativ...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$107K - $195K *

Join a team that's shaping the future of microgrid automation and renewable energy. Leverage your expertise in control systems and collaborate on innovative projects that drive sustainable energy solu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$150K - $238K *

Shape the future of digital manufacturing by leading strategic IT and operations initiatives. Drive multi-site transformation, ensuring seamless integration of technology and processes to enhance effi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Join a dynamic team as you optimize recipe and task build solutions, driving operational excellence and standardization. Collaborate across departments to enhance workflows and implement scalable proc...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Transform healthcare processes by leading quality improvement initiatives. Utilize lean, six sigma, and change management expertise to enhance operational excellence, patient satisfaction, and efficie...

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  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape the future of water and wastewater systems by leading projects from planning to optimization. Collaborate with diverse teams to deliver innovative solutions for municipal and industrial clients...

United StatesRemote

Today

  •   15+ years exp.  •   Technical Services

$80K - $95K *

Drive project success by managing operational aspects and liaising with stakeholders. Oversee schedules, assess issues, and develop solutions to ensure timely objectives. Integrate data for risk manag...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$156K - $220K *

Unlock your potential by leading the paid media strategy in a transformative role involving creative innovation and team development, driving growth through data-driven decisions across multiple chann...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Media

$65K - $116K *

Drive exceptional client experiences by leading delivery operations, managing relationships, and leveraging analytics to identify service gaps. Collaborate cross-functionally to ensure seamless execut...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$86K - $106K *

Drive advertiser growth by optimizing campaign performance and building strong client relationships. Collaborate with internal teams to enhance product offerings and ensure a seamless advertiser exper...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$180K - $220K *

Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$159K - $168K *

Discover impactful opportunities by leading state and local government affairs in the Midwest, advocating for public policies that enhance community engagement and support the growth of a leading e-co...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.