Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$208K *

Partner with us to guide students through the college admissions journey, offering tailored strategies and expert support in crafting compelling applications, ensuring they stand out in a competitive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $100K *

Drive impactful marketing strategies for diverse titles, blending digital expertise with audience insights to enhance revenue and author engagement. Lead cross-functional teams and innovate campaigns...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$100K - $150K *

Elevate your career by leading innovative research initiatives that shape industry strategies. Collaborate with top brands, utilizing your expertise in qualitative and quantitative methods to deliver...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $100K *

Unlock potential by leading innovative research initiatives that drive insights and strategies for top brands. Manage projects from design to delivery, utilizing both qualitative and quantitative meth...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $190K *

Champion project management excellence by leading a multidisciplinary team to support Navy modernization efforts. Drive strategic direction, enhance performance, and ensure alignment with client objec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $138K *

Elevate customer experience by leading technical engagement during pre-sales. Utilize deep knowledge to craft solutions, mentor peers, and ensure seamless transitions, while remaining adaptable in a f...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Unlock potential by providing in-home occupational therapy services, evaluating safety, assessing functional needs, and implementing personalized treatment plans to enhance patient independence and qu...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Elevate patient care by developing tailored rehabilitation plans, performing evaluations, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcomes and ensure...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$105K - $163K *

Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $160K *

Lead the charge in transforming legal operations by advising corporate legal departments on strategy, technology, and process improvements. Drive complex engagements, build trusted relationships, and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $120K *

Champion the management and execution of complex e-discovery projects, collaborating with legal teams to ensure successful outcomes. Oversee multiple projects while mentoring a team, maintaining quali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Elevate data architecture by leading design and governance for a critical modernization program, ensuring secure, scalable solutions in AWS GovCloud while collaborating with diverse stakeholders to ma...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$78K - $106K *

Transform client payment policies by ensuring accuracy and compliance. Engage with internal and external teams to manage medical policy updates, conduct analyses, and enhance client relationships whil...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$96K - $108K *

Transform patient care by joining our dynamic hospice team as a Travel RN. Provide compassionate support across multiple locations, ensuring quality and continuity of care while collaborating with loc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join a team that's dedicated to improving patient outcomes through comprehensive specialty care, managing both acute and chronic conditions while promoting health and well-being in collaboration with...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform patient care delivery by leading a dedicated team, optimizing operations, and enhancing staff performance to achieve organizational goals while ensuring high-quality patient outcomes...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Elevate patient care by providing age-specific pharmaceutical services and managing medication safety. Collaborate with healthcare teams to enhance clinical outcomes and contribute to departmental goa...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Unlock potential by embedding with customers to drive technical adoption and outcomes. Leverage your enterprise experience to build, deploy, and troubleshoot solutions while fostering trust with execu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $135K *

Lead a dynamic team to enhance accessibility in assessment content. Collaborate with cross-functional partners to shape strategies and standards, ensuring compliance with accessibility guidelines whil...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $180K *

Shape the visual identity of two distinct brands by designing impactful sales assets, web pages, and social graphics. Collaborate closely with marketing and sales teams to elevate brand presence in th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $190K *

Elevate our field marketing strategy by leading regional initiatives that drive demand for our software. Collaborate with sales teams to create impactful events and programs, while building and managi...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Optimize eDiscovery project management by driving workflows, ensuring quality, and meeting litigation requests. Collaborate with teams to enhance processes and maintain stakeholder communication for s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$157K - $184K *

Engineer and elevate our core product by developing innovative features, tools, and infrastructure while collaborating closely with a dedicated team to maintain high-quality standards and drive techni...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform your career by leading compliance assurance initiatives that enhance the reliability of the North American electric grid. Collaborate with industry stakeholders to develop and implement risk...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.