Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,063
$125K - $225K *
Elevate project success by leading multidisciplinary teams in nuclear design and program management, ensuring safety, quality, and compliance across all phases of construction and operations for compl...
2 weeks ago
Senior Product Manager - Inventory
$159K - $273K *
Shape the future of home listings by driving supply growth and enhancing buyer experiences. Lead AI-driven initiatives to optimize inventory presentation and engagement, ensuring Redfin remains the go...
2 weeks ago
Senior Sales Manager - Remote US
$110K - $130K *
Champion a high-growth sales strategy by developing a results-driven team to achieve revenue targets, expand market presence, and foster strategic client relationships while ensuring continuous improv...
2 weeks ago
$95K - $115K *
Drive your career with a leading role in bridge design, overseeing complex projects and mentoring junior engineers. Engage in innovative structural planning and analysis for transportation infrastruct...
2 weeks ago
Senior Software Engineer II, Mobile - Revenue Experiences (AI Native)
$118K - $216K *
Transform premium user experiences by owning the development and maintenance of features that drive revenue growth. Collaborate with cross-functional teams to deliver high-quality, AI-enhanced solutio...
2 weeks ago
Strategic Client Partner, Clinical
$250K - $350K *
Drive strategic account management in a hybrid role, fostering relationships with clinical stakeholders to enhance client engagement and expand revenue through trusted partnerships and targeted soluti...
Reposted 2 weeks ago
$90K - $110K *
Drive transformation by collaborating with stakeholders to analyze and enhance business processes, ensuring effective technology adoption and operational improvements within a dynamic environment...
2 weeks ago
Software Engineer I - LLM Observability
$160K - $180K *
Empower your career by delivering AI observability solutions end-to-end. Collaborate with a cross-functional team to enhance user experiences and drive insights into AI systems, shaping the future of...
2 weeks ago
$130K - $155K *
Lead the charge in driving end-to-end strategy and discovery for complex client engagements. Collaborate with cross-functional teams to deliver actionable insights, build trusted relationships, and na...
2 weeks ago
Senior Instructional System Designer
$95K - $115K *
Transform the learning landscape by leading the design and development of innovative educational materials. You'll engage diverse teams to create immersive, high-quality training experiences using cut...
Reposted 2 weeks ago
Manager, Credentialing & Medical Staff Services
$110K - $125K *
Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...
2 weeks ago
$100K - $120K *
Innovate pharmaceutical care by managing medication safety and clinical services. Supervise team efforts, contribute to departmental goals, and ensure optimal safety and efficiency through advanced pr...
Reposted 2 weeks ago
Mid-Market Account Executive, Healthcare SaaS
$80K - $95K *
Join a team that's driving growth in mid-market healthcare by building relationships, managing a dynamic sales pipeline, and closing new business opportunities in a fast-paced SaaS environment...
2 weeks ago
1741 - Director, Strategic Sourcing Facilities- Retail
$125K - $185K *
Join a team that's driving strategic sourcing excellence in Facilities for Retail accounts. Lead a dedicated team to deliver innovative solutions, manage supplier relationships, and ensure high-qualit...
2 weeks ago
Product Owner/Associate (foreUP)
$80K - $95K *
Drive product strategy and vision by collaborating with cross-functional teams, managing backlogs, and leveraging AI to enhance customer value. Ensure alignment between business needs and product deve...
2 weeks ago
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
$78K - $206K *
Unlock potential by leading clinical performance improvement projects for Medicare Provider Collaboration groups. Collaborate with teams to enhance population health outcomes, focusing on Stars qualit...
2 weeks ago
Associate Medical Director, Renal Cancer Theranostics
$175K - $210K *
Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...
2 weeks ago
Principal AI Software Engineer
$250K - $300K *
Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...
Reposted 2 weeks ago
Senior Manager, Global Credit & Collections
$140K - $160K *
Innovate by leading global Credit & Collections operations, driving cash performance, and managing customer credit risk. Collaborate with cross-functional teams to enhance processes, ensure compliance...
Reposted 2 weeks ago
Internal Audit Manager - Commercial Lending
$96K - $181K *
Elevate your career by leading risk-based internal audits, collaborating with business leaders to enhance governance and control processes. Drive audit planning, execution, and team development while...
2 weeks ago
Site Reliability Engineering Manager
$114K - $190K *
Build a resilient Site Reliability Engineering practice, leading a global team to enhance cloud platform reliability, scalability, and operational excellence while fostering collaboration and continuo...
2 weeks ago
Pod Leader, Corporate Strategic Sales
$150K - $215K *
Elevate growth at top global accounts by leading strategic sales initiatives, building executive relationships, and driving value-based solutions. Collaborate with cross-functional teams to achieve am...
2 weeks ago
Senior Account Executive, Existing Business - Financial Services
$143K - $197K *
Drive growth by managing existing client relationships in the Financial Services sector. Leverage your B2B SaaS sales expertise to upsell and expand market presence, contributing significantly to the...
2 weeks ago
Senior Partner Solutions Architect, Strategic Partnerships
$115K - $194K *
Lead the technical strategy for strategic partnerships, transforming partner needs into integrations and influencing product design. Collaborate with R&D to evaluate AI models and enhance GitLab's off...
2 weeks ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.