Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$125K - $185K *

Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$130K - $160K *

Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$190K - $225K *

Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$155K - $175K *

Lead the charge in client partnerships while driving strategic growth and team development. Utilize your expertise to deliver impactful insights and solutions in a fast-paced, evolving environment, en...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $90K *

Join a team that's dedicated to delivering exceptional investment management services. This role involves collaborating with Wealth Advisors to strategize and implement portfolio solutions, ensuring a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $116K *

Engage with customers to implement and optimize downstream processing technologies, providing technical expertise and support. Collaborate with stakeholders to enhance workflows and ensure successful...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join us to provide expert application support for cutting-edge separation technologies. Engage with customers throughout their journey, ensuring successful implementation and adoption while collaborat...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Join a team that's redefining cloud solutions by architecting innovative CaaS and cloud-native technologies. Collaborate with customers to tackle complex challenges and drive successful cloud transfor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $260K *

Unlock potential by driving sales growth in the Minnesota East territory, fostering relationships with physicians, and ensuring high adoption of innovative medical technologies while meeting sales quo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion pipeline growth by designing high-impact demand gen strategies across events, webinars, and campaigns, shaping the future of demand generation in a fast-paced environment focused on accountab...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$83K *

Transform the candidate experience by coordinating interviews and managing communications. Collaborate with recruiters and hiring managers to streamline processes, ensuring efficiency and excellence i...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $145K *

Lead the charge in leveraging advanced data science techniques to solve complex business challenges, mentor junior team members, and drive effective risk management through innovative algorithms and d...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$147K - $221K *

Lead the charge in developing and executing go-to-market strategies for innovative products, driving full-funnel demand generation and inbound pipeline growth through cross-functional collaboration an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$92K - $166K *

Transform critical systems for the US Antarctic Program by designing, deploying, and maintaining Linux-based infrastructure. Collaborate with cross-functional teams and lead operations in a unique, mi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$59K - $106K *

Drive high-voltage transmission line design projects, ensuring compliance with industry standards. Collaborate with multi-disciplinary teams to execute technical tasks, prepare documentation, and enha...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$69K - $108K *

Pioneer innovative solutions in Custom Air Handling Systems, collaborating with cross-functional teams to provide technical support and resolve complex challenges. Leverage your expertise to enhance c...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$139K - $188K *

Unlock potential by leading regulatory writing for complex submissions, mentoring junior writers, and driving departmental initiatives. Collaborate with cross-functional teams to ensure compliance and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $115K *

Champion financial insights and strategic modeling for home services, partnering with stakeholders to drive growth. Leverage FP&A expertise to manage budgets, forecasts, and variance analysis, ensurin...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Empower our High Net Worth Planning Services by providing expert financial strategies. Engage with advisors to deliver tailored solutions, addressing complex planning issues while mentoring junior tea...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $220K *

Drive impactful product marketing strategies for proactive security solutions, guiding market positioning, launches, and customer engagement. Collaborate with cross-functional teams to shape product d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Empower regulatory excellence by guiding cross-functional teams in compliance and strategy. Leverage deep FDA knowledge to influence promotional materials and ensure adherence to evolving regulations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$107K - $150K *

Engage with clients to design and implement advanced Physical Security Systems. Collaborate with top engineers on complex projects, ensuring high-quality solutions and customer satisfaction while mana...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$192K - $252K *

Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.