Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$110K - $130K *

Lead tax compliance and planning for high-net-worth clients, overseeing engagements and fostering team growth. Drive business development while ensuring technical excellence and proactive client servi...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $130K *

Drive product marketing for innovative defense tech solutions. Collaborate with cross-functional teams to shape strategies, develop compelling narratives, and execute impactful campaigns that enhance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$180K - $195K *

Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $146K *

Drive digital customer success initiatives by designing and optimizing targeted journeys throughout the customer lifecycle, enhancing engagement and adoption while collaborating cross-functionally to...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$185K - $210K *

Lead the charge in transforming TMC implementations by defining processes, configuring platforms, and training teams to ensure seamless transitions and rapid go-lives across multiple projects simultan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$87K - $139K *

Join a dynamic team as a senior technical lead in enterprise data engineering, responsible for architecting and optimizing scalable data platforms. Drive data quality and observability while collabora...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$142K - $186K *

Deliver trusted, governed product data by designing scalable ELT pipelines and analytics models. Collaborate across teams to ensure data quality and compliance, empowering stakeholders with self-servi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $154K *

Elevate project success by managing permit tracking and regulatory compliance, ensuring adherence to local, state, and federal requirements while supporting incentive-related activities for optimal be...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $165K *

Innovate user experiences by transforming legacy workflows into modern web applications. Lead the development of data-driven analytics tools using cutting-edge technologies, collaborating with cross-f...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$185K - $230K *

Shape the future of patient access by leading reimbursement strategies and support for rare disease therapies. Collaborate cross-functionally to enhance provider education and patient understanding, e...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $162K *

Lead enhancements in Salesforce HealthCloud to optimize solutions and integrations, collaborate with teams, and deliver scalable applications that ensure high-quality data and security compliance for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Advance the future of pediatric health by leading medical strategy, safety, and clinical communications. Collaborate with healthcare providers and internal teams to enhance product development and ens...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$143K - $169K *

Unlock potential by developing and maintaining ASC 606 revenue policies, ensuring compliance and accuracy in revenue recognition. Collaborate cross-functionally to shape contract structures and suppor...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$94K - $118K *

Champion client success by managing strategic Enterprise accounts, driving growth through innovative solutions and collaboration. Leverage AI tools to transform workflows and enhance client relationsh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $190K *

Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive your career with a Senior Program Analyst role focused on solving complex cross-functional challenges. Utilize analytical skills to enhance pricing, agreements, and program performance while col...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$177K - $195K *

Engage with healthcare professionals to build relationships and provide education on HAE treatment. Drive access support and promote Donidalorsen while collaborating with cross-functional teams to enh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead strategies to drive environmental due diligence growth, manage key client relationships, oversee project execution, and ensure delivery of high-quality results through effective team leadership a...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$112K - $145K *

Drive GTM Analytics within Revenue Strategy, shaping performance metrics, data governance, and analytical support for strategic decisions. Collaborate with cross-functional teams to enhance channel ec...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$220K - $290K *

Elevate the user experience in healthcare by leading design innovation! You'll spearhead our design strategy, fostering a high-performance team while simplifying complex workflows into intuitive, beau...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Deliver exceptional consulting services by managing client implementations, diagnosing technical issues, and providing tailored solutions. Collaborate with cross-functional teams to ensure seamless in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining event marketing by leading high-impact programs that enhance customer engagement and drive revenue. You'll strategize and execute user summits, trade shows, and field eve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.