Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$117K - $129K *

Lead the charge in optimizing operational performance for solar energy projects. Collaborate with engineers to analyze performance data, develop solutions, and ensure project success, while fostering...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $100K *

Unlock insights through quantitative analysis and research, shaping energy policy scenarios while collaborating with stakeholders to enhance philanthropic grantmaking efforts and present findings thro...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$54K - $159K *

Shape the future of healthcare by leading enterprise EHR policy development and workflow standardization. Collaborate across teams to enhance patient safety and operational efficiency while assessing...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$82K - $131K *

Join a dynamic team as a Solution Engineer to drive retail sales success through technical expertise, product demonstrations, and customer solutions, while collaborating closely with sales and product...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Join a team that's driving innovation in Oracle E-Business Suite solutions. Leverage your expertise to enhance customer engagements and support pre-sales initiatives while collaborating with cross-fun...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$225K - $281K *

Shape the future of application security by leading strategy and initiatives across teams. Drive secure design and standards, mentor engineers, and tackle complex security challenges in a collaborativ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining brand identity! Lead and evolve visual strategies across digital and print, guiding a talented design team while executing high-impact projects in a fast-paced, collabora...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$125K - $150K *

Pioneer a new field sales organization by leading a team of Territory Managers to drive growth through independent agencies. Collaborate cross-functionally to enhance performance and achieve productio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$119K - $140K *

Shape the future of technology in healthcare by leading development efforts, leveraging AI tools, and ensuring high-quality digital deliverables across multiple platforms. Collaborate with creative te...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $185K *

Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $245K *

Unlock potential by leading product strategy across diverse teams, driving innovation in a dynamic marketplace. Collaborate with engineering and design to enhance user experiences for pet parents and...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$90K - $100K *

Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive the delivery and maintenance of Interactive Response Technology (IRT) systems, ensuring successful client interactions and project outcomes through effective oversight, training, and support man...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $265K *

Partner with us to lead a high-performing engineering team, driving innovation and efficiency in our travel marketplace. You'll manage project lifecycles, enhance collaboration, and champion a custome...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Empower clients by managing energy procurement operations, leading RFP processes, and delivering market insights. Collaborate with suppliers and customers to optimize strategies in deregulated electri...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$146K - $211K *

Partner with us to drive market development in rare hematology, engaging KOLs and HCPs to enhance education and insights. Shape brand strategy and foster connections across specialists to improve pati...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower public-sector organizations by driving technology solutions in Washington. Develop new relationships, expand accounts, and collaborate with teams to enhance government operations and education...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $167K *

Innovate within our network security team by leading the engineering and automation of enterprise security platforms. Drive technical excellence and enhance infrastructure management through modern pr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$204K - $264K *

Lead the charge in shaping technical strategy and fostering a culture of quality within your team, ensuring operational excellence and collaboration across product development to drive impactful busin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$84K - $114K *

Lead a dynamic team in delivering high-quality digital implementations, driving strategy and process improvements while ensuring customer satisfaction and operational excellence in a fast-paced enviro...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Pioneer innovative solutions as a Senior Software Engineer, collaborating with a seasoned team to tackle complex challenges. Drive product development in a fully remote environment, focusing on user n...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$185K - $230K *

Elevate patient access by managing reimbursement strategies for rare diseases. Collaborate with healthcare providers and internal teams to ensure compliance and support patient journeys through comple...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $158K *

Partner with us to lead transformative CRM implementations, guiding clients through strategy, execution, and optimization. Leverage your expertise to mentor teams and drive innovative solutions that e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Inspire data-driven decision-making as you lead analytics and predictive modeling efforts. Collaborate across teams to enhance patient engagement, forecast demand, and measure impact, driving strategi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $180K *

Build a robust data foundation to elevate Market Intelligence. Drive automation and streamline data workflows, enriching insights for research and publishing, while ensuring data integrity and accessi...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.