Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,961
Performance Engineer II (Remote)
$117K - $129K *
Lead the charge in optimizing operational performance for solar energy projects. Collaborate with engineers to analyze performance data, develop solutions, and ensure project success, while fostering...
Reposted 2 weeks ago
Analyst (Energy and Climate Modeling)
$80K - $100K *
Unlock insights through quantitative analysis and research, shaping energy policy scenarios while collaborating with stakeholders to enhance philanthropic grantmaking efforts and present findings thro...
Reposted 2 weeks ago
Manager-Clinical Informatics - Policy, Quality & Safety
$54K - $159K *
Shape the future of healthcare by leading enterprise EHR policy development and workflow standardization. Collaborate across teams to enhance patient safety and operational efficiency while assessing...
Reposted 2 weeks ago
Presales Solution Engineer | Retail
$82K - $131K *
Join a dynamic team as a Solution Engineer to drive retail sales success through technical expertise, product demonstrations, and customer solutions, while collaborating closely with sales and product...
Reposted 2 weeks ago
$135K - $160K *
Join a team that's driving innovation in Oracle E-Business Suite solutions. Leverage your expertise to enhance customer engagements and support pre-sales initiatives while collaborating with cross-fun...
2 weeks ago
Staff Application Security Engineer
$225K - $281K *
Shape the future of application security by leading strategy and initiatives across teams. Drive secure design and standards, mentor engineers, and tackle complex security challenges in a collaborativ...
2 weeks ago
$110K - $130K *
Join a team that's redefining brand identity! Lead and evolve visual strategies across digital and print, guiding a talented design team while executing high-impact projects in a fast-paced, collabora...
2 weeks ago
Director, Territory Management
$125K - $150K *
Pioneer a new field sales organization by leading a team of Territory Managers to drive growth through independent agencies. Collaborate cross-functionally to enhance performance and achieve productio...
2 weeks ago
21GRAMS- Senior Technology Lead
$119K - $140K *
Shape the future of technology in healthcare by leading development efforts, leveraging AI tools, and ensuring high-quality digital deliverables across multiple platforms. Collaborate with creative te...
Reposted 2 weeks ago
Group Account Director (Medical Affairs)
$165K - $185K *
Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...
Reposted 2 weeks ago
$195K - $245K *
Unlock potential by leading product strategy across diverse teams, driving innovation in a dynamic marketplace. Collaborate with engineering and design to enhance user experiences for pet parents and...
2 weeks ago
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 2 weeks ago
$95K - $115K *
Drive the delivery and maintenance of Interactive Response Technology (IRT) systems, ensuring successful client interactions and project outcomes through effective oversight, training, and support man...
2 weeks ago
Senior Manager, Software Engineering
$225K - $265K *
Partner with us to lead a high-performing engineering team, driving innovation and efficiency in our travel marketplace. You'll manage project lifecycles, enhance collaboration, and champion a custome...
2 weeks ago
$80K - $95K *
Empower clients by managing energy procurement operations, leading RFP processes, and delivering market insights. Collaborate with suppliers and customers to optimize strategies in deregulated electri...
2 weeks ago
Rare Hematology Thought Leader Liaison
$146K - $211K *
Partner with us to drive market development in rare hematology, engaging KOLs and HCPs to enhance education and insights. Shape brand strategy and foster connections across specialists to improve pati...
Reposted 2 weeks ago
Senior Account Manager, SLED-WA
$110K - $130K *
Empower public-sector organizations by driving technology solutions in Washington. Develop new relationships, expand accounts, and collaborate with teams to enhance government operations and education...
2 weeks ago
Lead Consultant - Network Security
$98K - $167K *
Innovate within our network security team by leading the engineering and automation of enterprise security platforms. Drive technical excellence and enhance infrastructure management through modern pr...
2 weeks ago
Manager, Software Engineering (Loans Lifecycle)
$204K - $264K *
Lead the charge in shaping technical strategy and fostering a culture of quality within your team, ensuring operational excellence and collaboration across product development to drive impactful busin...
2 weeks ago
Digital Delivery Implementation Manager
$84K - $114K *
Lead a dynamic team in delivering high-quality digital implementations, driving strategy and process improvements while ensuring customer satisfaction and operational excellence in a fast-paced enviro...
Reposted 2 weeks ago
$120K - $145K *
Pioneer innovative solutions as a Senior Software Engineer, collaborating with a seasoned team to tackle complex challenges. Drive product development in a fully remote environment, focusing on user n...
Reposted 2 weeks ago
Field Reimbursement Manager-Northeast
$185K - $230K *
Elevate patient access by managing reimbursement strategies for rare diseases. Collaborate with healthcare providers and internal teams to ensure compliance and support patient journeys through comple...
2 weeks ago
Master Consultant, HubSpot & CRM Solutions
$117K - $158K *
Partner with us to lead transformative CRM implementations, guiding clients through strategy, execution, and optimization. Leverage your expertise to mentor teams and drive innovative solutions that e...
2 weeks ago
Head of Data Science & Analytics
$150K - $180K *
Inspire data-driven decision-making as you lead analytics and predictive modeling efforts. Collaborate across teams to enhance patient engagement, forecast demand, and measure impact, driving strategi...
2 weeks ago
$130K - $180K *
Build a robust data foundation to elevate Market Intelligence. Drive automation and streamline data workflows, enriching insights for research and publishing, while ensuring data integrity and accessi...
Reposted 2 weeks ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.