Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$120K - $135K *

Join a team that shapes innovative medical strategies, driving excellence in healthcare content. Collaborate with experts, cultivate client relationships, and inspire teams to elevate project outcomes...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive the evolution of a cutting-edge CI/CD platform, integrating AI tools and leading a team of DevOps engineers. Own production releases and implement modern delivery practices to enhance software d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Partner with us to drive sales operations excellence, ensuring effective workflows, data integrity, and actionable insights in a dynamic environment while supporting strategic initiatives and enhancin...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$103K - $108K *

Advance client partnerships by managing outreach, proposals, and relationships. Collaborate with teams to drive revenue and leverage AI tools for efficiency in sales processes, ensuring alignment with...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $124K *

Shape the future of client partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue through innovative AI tools and workflows. Collaborate with teams to optim...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$327K - $408K *

Lead the charge in shaping long-term marketing strategies and partnerships, overseeing a dynamic team to drive growth and enhance market positioning through innovative co-marketing initiatives and cro...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$114K - $143K *

Drive operational excellence as a Program Manager, enhancing EPD processes and collaboration. Leverage data insights to identify trends, improve efficiency, and support cross-functional teams in a dyn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$185K - $230K *

Empower patient access by leading reimbursement strategies in rare diseases. Collaborate cross-functionally to navigate complex pathways, educate providers, and support patients, ensuring compliance a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Empower growth by driving new revenue for political strategy and advocacy, shaping customer engagement, and developing impactful relationships with top-tier clients while leading a high-performing bus...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $94K *

Innovate proposal strategies by leading the development of cohesive submissions, coordinating resources, and ensuring compliance. Collaborate with cross-functional teams to enhance win themes and impr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$265K - $295K *

Engage communities as a trusted partner, fostering relationships and collaboration throughout the lifecycle of infrastructure projects. Shape local engagement strategies, ensuring transparency and mut...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $185K *

Join a dynamic team as a Senior Marketing Analytics Manager, driving marketing performance measurement and insights. Collaborate cross-functionally to build impactful reporting and attribution models...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$155K - $170K *

Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Staffing

$185K - $230K *

Advance patient access and reimbursement strategies in rare diseases. Collaborate cross-functionally to educate providers and support patients, ensuring compliance and effective navigation of complex...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$68K - $109K *

Transform installed base management by leading operations and ensuring data integrity. Collaborate cross-functionally to optimize asset management processes and provide guidance as the primary platfor...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $185K *

Lead cross-functional teams to drive excellence in software development for a SaaS platform, ensuring timely delivery and high-quality outcomes while fostering a collaborative engineering culture. Inn...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$225K - $324K *

Accelerate growth by leading global enablement initiatives that empower sellers, engineers, and partners. Drive strategic programs, enhance skills, and ensure readiness for a multi-product platform in...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$144K - $170K *

Empower enterprise security sales as a relentless hunter, leveraging diverse demand gen strategies. Drive revenue growth by developing prospects, closing new deals, and expanding customer relationship...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Join a team that's driving strategic partnerships in Retail and Hospitality. Manage relationships with technology providers, identify growth opportunities, and develop compelling business cases to enh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $210K *

Transform healthcare communications by strategizing and executing impactful media outreach, building relationships, and crafting compelling narratives that resonate with consumers and industry leaders...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Elevate customer success by leading a global team to enhance retention and expansion strategies. Drive value delivery through AI tools, customer engagement, and cross-functional collaboration, ensurin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$68K - $115K *

Unlock global payroll efficiency by managing accurate, timely payments across multiple countries. Leverage AI and automation to streamline processes, ensure compliance, and enhance employee experience...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $140K *

Advance your career by implementing and enhancing health and safety programs across the West Coast. Collaborate with leaders and teams to ensure compliance, conduct audits, and foster a culture of saf...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$210K - $250K *

Lead strategic business development initiatives, driving deal execution and relationship management with senior health plan stakeholders. Shape growth strategies and negotiate value-based care contrac...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a team that's redefining customer engagement by leveraging advanced platform capabilities. Collaborate with sales and technical teams to deliver tailored solutions, driving value and enhancing th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.