Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in advancing enterprise automation capabilities, driving quality engineering innovation, and influencing strategic decisions across a rapidly growing organization, enhancing software r...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$89K - $133K *

Empower success by leading healthcare technology implementations, optimizing workflows, and ensuring compliance. Collaborate across teams to guarantee smooth integrations and enhance system functional...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $200K *

Lead the charge in vulnerability management, driving remediation efforts and enhancing security across cloud environments. Collaborate with cross-functional teams to reduce risks and improve operation...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$185K - $210K *

Lead the charge in optimizing revenue operations by enhancing forecasting, analytics, and sales strategies to drive growth and accountability across North America’s sales teams, ensuring alignment and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Join a team that's redefining network solutions by designing, implementing, and supporting advanced LAN, WAN, and wireless systems. Collaborate with cross-functional leaders to enhance network strateg...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform patient care as a Hospice RN Team Director, leading a dedicated team to deliver compassionate support. Oversee assessments, manage staff, and enhance quality of care while fostering a collab...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $205K *

Drive financial excellence by delivering insights and analysis for the Field Service organization. Collaborate across departments to enhance forecasting, budgeting, and operational efficiency while su...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$108K - $157K *

Optimize data-driven strategies by transforming raw analytics into actionable insights. Collaborate with cross-functional teams to enhance marketplace dynamics and drive measurable business outcomes i...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$122K - $203K *

Empower teams by leading data governance initiatives, enhancing data quality, and fostering collaboration across business domains. Drive operational excellence and ensure compliance while developing a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$74K - $203K *

Drive integration excellence by overseeing OIC implementations and collaborating with stakeholders to enhance enterprise applications. Play a key role in optimizing performance and ensuring seamless c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $170K *

Engage with strategic accounts by leading a dynamic team of Technical Account Managers, enhancing customer relationships and driving satisfaction through tailored strategies and exceptional service, e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Drive the future of technical sales leadership by managing a team of Solutions Engineers, enhancing enterprise adoption of cutting-edge technologies, and ensuring technical wins through strategic part...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock potential by driving strategic insights and operational excellence in a dynamic environment. Collaborate across teams to analyze complex problems, shape pricing strategies, and support market e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$250K - $325K *

Champion the development and execution of innovative sales enablement programs, collaborating with cross-functional teams to enhance training, elevate performance, and drive growth in the competitive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$217K - $310K *

Elevate your career by leading investor relations and strategic finance initiatives. Collaborate with executives to craft compelling narratives, build investor relationships, and drive impactful finan...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$148K - $263K *

Join a team that's dedicated to developing innovative ServiceNow solutions, enhancing system performance, and ensuring compliance with federal security frameworks while collaborating with stakeholders...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$109K - $183K *

Join a team that's driving innovation in product operations. You'll manage program initiatives, streamline processes, and enhance portfolio reporting while collaborating with cross-functional teams to...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$103K - $108K *

Transform client relationships as you drive revenue growth through strategic outreach, proposal crafting, and collaboration. Leverage AI tools to enhance efficiency and insights while supporting the s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Elevate customer success by leading a dynamic team focused on driving adoption, enhancing relationships, and achieving measurable outcomes through collaboration and strategic initiatives across variou...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $135K *

Drive client success by managing a diverse portfolio, enhancing relationships, and implementing strategies for retention and growth. Utilize analytical insights to navigate complex client needs and fo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$92K - $155K *

Unlock potential by partnering with leaders to drive talent strategies that align with business goals, enhance team performance, and foster a culture of growth and inclusivity in a fast-paced, innovat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Engage key customers to maximize revenue and profitability through strategic account planning, fostering value-driven relationships, and enhancing collaboration across business units for long-term gro...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by designing and managing Azure infrastructure, ensuring seamless hybrid connectivity and robust disaster recovery. Collaborate across teams to enhance operations, automate processes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Lead market expansion and provider relationships through consultative sales strategies, driving revenue growth and pipeline management within a dynamic healthcare environment while leveraging AI tools...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.