Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$150K - $200K *

Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...

United StatesRemote

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  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$157K - $196K *

Drive safety evaluation and risk management for assigned programs, collaborating with cross-functional teams to ensure compliance and effective governance in pharmacovigilance activities, while suppor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $165K *

Advance your career by leading Yardi software implementations for public housing clients. Collaborate with stakeholders to optimize workflows, enhance system configurations, and drive operational exce...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $165K *

Join a team that's dedicated to enhancing public housing through Yardi software implementation. Leverage your expertise to optimize client workflows, troubleshoot issues, and drive value in affordable...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $165K *

Elevate public housing solutions by leading Yardi software implementations, optimizing workflows, and enhancing client relationships. Drive operational excellence through expert guidance in affordable...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Shape the future of finance by leading a dynamic team in delivering exceptional outsourced accounting solutions, driving business development, and mentoring talent while ensuring client satisfaction a...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Champion the development of a robust outsourced finance practice, delivering exceptional client service while mentoring team members and managing financial performance across diverse client portfolios...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Lead the charge in building a robust outsourced finance and accounting practice, delivering exceptional client service, mentoring team members, and driving business development while managing financia...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $120K *

Elevate your career by leading a dynamic team in outsourced finance and accounting. Drive client success through exceptional service, innovative solutions, and strategic business development while men...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Reimagine client finance solutions by leading a dynamic team, enhancing service delivery, and driving business growth through innovative strategies and technology integration. Foster relationships and...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$80K - $95K *

Contribute to dental practice success by delivering impactful, in-person training on digital workflows and intraoral scanning. Collaborate with clinicians and staff to enhance clinical performance and...

United StatesRemote

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  •   Less than 5 years exp.  •   Healthcare

$125K - $225K *

Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$120K - $151K *

Shape the product roadmap and drive delivery from discovery to launch, collaborating with cross-functional teams to ensure customer-centric solutions and measurable business outcomes in a dynamic B2B...

United StatesRemote

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  •   Less than 5 years exp.  •   Enterprise Technology

$71K - $113K *

Contribute to project success by managing cost and schedule for plant outages. Collaborate with project teams to analyze budgets, track progress, and ensure timely reporting, all while adhering to pro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$93K - $104K *

Join a nationwide team as a Physical Therapist Assistant, delivering essential rehab services across various settings while enhancing patient independence under expert supervision. Enjoy the flexibili...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$85K - $135K *

Collaborate to drive technical issue resolution and enhance support systems while serving enterprise clients across our AI platform, ensuring seamless communication and operational excellence in a fas...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$144K - $211K *

Lead the charge in managing complex Industrial Controls workstreams, ensuring seamless execution of NPI programs. Collaborate across teams to deliver innovative automation solutions on time and within...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Transform complex systems through expert programming in Natural and ADABAS. Lead large-scale projects on IBM Mainframe/Linux, enhancing automated eligibility systems while providing strategic recommen...

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$142K - $235K *

Deliver strategic leadership in driving sales growth across non-commercial channels. Manage a team to implement innovative strategies, enhance customer partnerships, and achieve financial goals while...

United StatesRemote

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  •   5 - 7 years exp.  •   Food & Beverages

$116K - $194K *

Elevate your career by joining a dynamic engineering team focused on ATM and TCR technologies. As a key technical specialist, you'll enhance customer-facing banking services through innovative solutio...

United StatesRemote

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  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $167K *

Join a team that's driving impactful earned media strategies in a dynamic, fast-paced environment. Lead media relations, secure placements, and maintain brand consistency while leveraging AI tools for...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$224K - $431K *

Join a team that's redefining AI networking by driving innovation in performance and scalability of distributed systems, optimizing data processing for large language models and generative AI workload...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$85K - $100K *

Analyze performance metrics to empower ACOs in Value-Based Care programs. Collaborate with teams to provide actionable insights, track KPIs, and optimize risk scores, driving data-driven decisions for...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$76K - $87K *

Unlock potential by delivering personalized patient care through advanced technology and collaboration with a dedicated dental team. Enjoy flexible scheduling and ongoing professional development in a...

Today

  •   Less than 5 years exp.  •   Healthcare

$76K - $87K *

Empower patient care by joining a dynamic team that values collaboration, innovation, and professional growth. Enjoy flexible scheduling and advanced technology while delivering exceptional dental hyg...

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.