Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$97K - $138K *

Help us shape the future of competitive intelligence by leading strategic initiatives that drive market insights and customer advocacy, enhancing our sales and marketing efforts while fostering strong...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Lead a dynamic team in a large manufacturing area to enhance product quality and customer satisfaction. Drive continuous improvement initiatives while ensuring safety and efficiency in maintenance ope...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$178K - $294K *

Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Collaborate with healthcare providers to drive commercial performance and product adoption. Engage in territory business planning, support product launches, and optimize patient access to innovative t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$155K - $194K *

Join us to lead impactful HCP marketing execution, driving adoption and engagement through strategic field initiatives. Collaborate cross-functionally to optimize resources and enhance customer experi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Advance your career by leading a dynamic machining team, driving Lean Manufacturing initiatives, and enhancing operational efficiency across safety, quality, and cost metrics. Collaborate with diverse...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K *

Transform our Workday environment by optimizing HCM and Payroll systems, ensuring seamless integrations and compliance. Collaborate cross-functionally to enhance processes and drive strategic improvem...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $192K *

Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Manage territory business plans to drive sales performance, engage healthcare providers, and support product launches. Collaborate with cross-functional teams to optimize patient access and ensure com...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Drive your career with a key role in expanding partner relationships and sales strategies within a dynamic market. You'll leverage your expertise to lead complex accounts and influence senior stakehol...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $200K *

Lead the charge in customer success by driving enterprise account value, fostering relationships, and orchestrating resources to ensure measurable outcomes. Collaborate with stakeholders to enhance pl...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $192K *

Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to enhance patient access and support innovative therapies in a dyn...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Your expertise will enhance patient access to innovative therapies an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Shape the future of healthcare by driving commercial performance and building strong relationships with healthcare providers. Engage in product launches and optimize patient access to innovative thera...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Shape the future of healthcare by driving commercial performance and building strong relationships with providers. Engage in product launches and optimize patient access to innovative therapies across...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Accelerate progress at driving commercial performance by engaging healthcare providers, building relationships, and supporting product launches to ensure patient access to innovative therapies across...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access. Engage healthcare providers, support product launches, and collaborate with cross-functional partners to achieve sales g...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $185K *

Champion strategic growth by driving solution sales within key enterprise accounts. Collaborate with cross-functional teams to identify opportunities, articulate value, and influence client transforma...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Pioneer innovative finance systems to enhance automation and reporting. Lead the integration of AI and controls in a fast-growing mental health company, collaborating across teams to ensure scalable f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $140K *

Lead the resolution of complex construction defect claims while managing a diverse portfolio. Collaborate with teams to ensure compliance and strategic outcomes, enhancing operational efficiency and c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Engage healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring compliance and lever...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $105K *

Join a team that drives strategic investment initiatives by engaging advisors, managing relationships, and advancing opportunities in alternative investments, ensuring success in a dynamic financial s...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.