Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$133K - $153K *

Provide exceptional service by installing, troubleshooting, and maintaining MRI and CT equipment. Foster strong customer relationships while managing service performance and operations in the NY Metro...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$162K - $224K *

Elevate healthcare solutions by driving business development in neurodegenerative disease pathways. Collaborate with health systems and stakeholders to identify needs, develop strategies, and create i...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$145K - $200K *

Lead the charge in developing and executing innovative marketing strategies for stroke care solutions, driving demand and visibility across diverse healthcare audiences while collaborating with cross...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$204K - $290K *

Elevate your career by driving strategic engagement with Key Opinion Leaders in oncology. Collaborate with cross-functional teams to enhance brand strategies and execute impactful marketing initiative...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$84K - $100K *

Transform premium accounting operations by leading teams, ensuring compliance, and driving process improvements through analytics and AI tools. Collaborate cross-functionally to enhance service levels...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$83K - $133K *

Lead customer engagement and technical design for critical power projects, ensuring quality and compliance. Collaborate across teams to resolve issues and manage multiple projects, driving successful...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$118K - $189K *

Transform data into actionable insights by leading innovative actuarial solutions. Drive the development of complex data systems, ensuring accuracy and quality for financial reporting while collaborat...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team providing strategic legal counsel on employment law matters, including employee relations and litigation management. Collaborate with HR and business leaders to mitigate risks and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $184K *

Unlock potential by leveraging clinical expertise to enhance pharmacy benefit management, analyze drug trends, and build strong client relationships. Drive strategic recommendations and support client...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$220K - $250K *

Lead enterprise security operations and resilience, driving cyber risk strategy and innovation. Collaborate cross-functionally to embed security principles, modernize defenses, and build high-performi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$139K - $208K *

Join a team that's transforming Global Supply Chain and ERP processes. As a Staff Business Process Leader, you'll drive process standardization, support ERP transformations, and engage with stakeholde...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$110K - $130K *

Optimize and support database platforms, focusing on MySQL and SQL Server migrations to AWS. Lead performance tuning, replication, and maintenance while collaborating with developers to enhance databa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K *

Take ownership of complex mortgage loan evaluations, ensuring compliance with guidelines while assessing borrower risk. Collaborate with internal teams and vendors to facilitate loan approvals and mai...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$95K - $115K *

Join a team that's dedicated to enhancing pediatric care by expertly managing medication therapies, advising healthcare professionals, and ensuring safe pharmaceutical practices in a dynamic NICU envi...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $140K *

Join a dynamic team to drive insurance product design and implementation. Collaborate cross-functionally to manage projects, ensuring alignment with strategic goals while facilitating effective busine...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $112K *

Lead the charge in clinical trial monitoring, ensuring compliance and data integrity while managing site operations and training staff. Collaborate with teams to deliver high-quality patient care and...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $112K *

Join a team that's dedicated to advancing clinical research by ensuring high standards of care and compliance in monitoring clinical trials. Leverage your expertise in oncology and clinical monitoring...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Empower your marketing expertise to drive strategy, revenue, and brand positioning across multiple segments. Lead a dynamic team, collaborate with executives, and shape customer advocacy initiatives t...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$136K - $204K *

Transform enterprise marketing by owning ABM strategy, driving pipeline growth, and executing tailored campaigns. Collaborate cross-functionally to engage key accounts and achieve revenue targets thro...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $105K *

Collaborate with cross-functional teams to enhance EHR workflows, improve operations, and optimize patient care through effective configuration and analysis of Professional Billing Claims applications...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$163K - $306K *

Champion the future of laboratory innovation by leading global product strategy, connecting emerging technologies and customer insights to drive impactful business initiatives across diverse markets...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$107K - $204K *

Pioneer innovative contracting solutions in a dynamic environment. Leverage your expertise in U.S. Government and commercial contracts to drive success within integrated project teams while ensuring c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$82K - $131K *

Drive comprehensive audits and enhance internal controls across business units. Collaborate with stakeholders to assess risks, implement improvements, and ensure compliance while leading audit engagem...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$54K - $135K *

Design innovative fire sprinkler systems by analyzing building plans and specifications. Collaborate on equipment selection and optimize designs using cutting-edge software. Ensure compliance with saf...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.