Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$120K - $145K *

Shape the future of Salesforce solutions by designing and implementing innovative architectures that meet client needs. Collaborate with stakeholders to deliver high-value solutions in a dynamic, fast...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $140K *

Optimize Salesforce capabilities in a federal environment by leading projects, managing requirements, and enhancing user experiences through effective configuration and migration strategies. Join us t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$190K - $300K *

Transform medical affairs by driving scientific excellence and strategic initiatives in ophthalmology. Collaborate with cross-functional teams to enhance field readiness and optimize engagement across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$173K - $272K *

Unlock potential by leading global regulatory strategies for immunology projects, ensuring compliance and optimizing product approvals. Collaborate with cross-functional teams and regulatory agencies...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$81K *

Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the enhancement of security measures for cloud-based healthcare solutions, focusing on vulnerability management, incident response, and compliance. Collaborate with cross-functional teams to ensu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$122K - $179K *

Advance your career by leading enterprise analytics and data governance initiatives. Collaborate with executive leadership to create analytics solutions that drive strategic decision-making and enhanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $180K *

Empower commercial operations by leading a dynamic Deal Desk team, driving strategy, optimizing processes, and executing complex transactions in a fast-paced SaaS environment. Collaborate cross-functi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Deliver innovative mineral processing solutions to enhance plant operations, optimize costs, and improve product quality. Collaborate with cross-functional teams to drive project success and ensure co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$115K - $120K *

Reimagine behavioral health by delivering impactful counseling services remotely. Engage with clients facing various challenges, conduct evaluations, and maintain thorough documentation while adhering...

Jackson, MSRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $120K *

Provide remote counseling services to adults, addressing mental health concerns through telehealth. Engage in direct client work, evaluate needs, and maintain documentation while adhering to ethical s...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Transform infrastructure engineering by leading a global team to develop and implement design standards for AI factories, ensuring consistency and efficiency across projects while driving innovation a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$84K - $112K *

Lead the charge in optimizing network capacity and implementing innovative solutions. Collaborate across teams to ensure best-in-class service delivery while managing projects and driving strategic in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$135K - $160K *

Champion growth strategies across defense IT and ISR systems, building senior relationships and managing opportunities at Wright-Patterson AFB. Drive innovation in C2 modernization and lead proposal d...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$135K - $160K *

Transform your career by leading cross-functional teams to drive drug development strategies. Collaborate with key stakeholders to ensure successful execution of integrated plans, manage risks, and de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$94K - $136K *

Transform financial insights into strategic decisions by providing advanced analytical support across Finance, Operations, and Strategic Planning. Collaborate with leadership to drive impactful projec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $100K *

Optimize coding operations by leading a team to ensure compliance, accuracy, and efficiency in billing processes. Collaborate with stakeholders to enhance documentation quality and coding integrity wh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $180K *

Lead the resolution of complex integration issues, collaborating with cross-functional teams to enhance reliability and support. Develop documentation and tools that empower partners and improve opera...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$89K - $150K *

Optimize sales operations by managing forecasting and data analytics to enhance revenue delivery. Collaborate with cross-functional teams to ensure data accuracy and support sales processes, enabling...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$274K - $371K *

Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Shape the future of HR compliance and risk management by leading initiatives that ensure adherence to laws and regulations, partnering with key stakeholders to mitigate risks and enhance operational e...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $110K *

Transform business opportunities within the public transit sector by leading complex sales cycles and fostering relationships with government agencies to drive growth and implement tailored software s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$71K - $108K *

Drive customer success by managing technical relationships and advocating for best practices in public cloud environments. Leverage your expertise to enhance customer experiences and ensure alignment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.